Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: safety, tolerability, pharmacokinetics and pharmacodynamics--results from single oral dose studies in healthy volunteers. (Q36792968)

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scientific article published on May 2013

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English	Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: safety, tolerability, pharmacokinetics and pharmacodynamics--results from single oral dose studies in healthy volunteers.	scientific article published on May 2013

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scholarly article

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9 March 2020

Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: safety, tolerability, pharmacokinetics and pharmacodynamics--results from single oral dose studies in healthy volunteers (English)

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Europe PubMed Central

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9 March 2020

pharmacokinetics

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inferred from title

pharmacodynamics

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2

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9 March 2020

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S Aubrey Stoch

1

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9 March 2020

Julie A Stone

3

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9 March 2020

Deborah L Miller

4

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9 March 2020

Lucas van Bortel

5

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9 March 2020

Kenneth C Lasseter

6

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9 March 2020

Barnali Pramanik

7

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9 March 2020

Caroline Cilissen

8

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9 March 2020

Qi Liu

9

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9 March 2020

Lida Liu

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9 March 2020

Boyd B Scott

11

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9 March 2020

Deborah Panebianco

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9 March 2020

Yu Ding

13

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9 March 2020

Keith Gottesdiener

14

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9 March 2020

John A Wagner

15

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9 March 2020

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1 May 2013

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9 March 2020

British Journal of Clinical Pharmacology

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9 March 2020

75

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9 March 2020

5

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9 March 2020

1240-1254

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9 March 2020

Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

29 September 2017

Successes achieved and challenges ahead in translating biomarkers into clinical applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

29 September 2017

Bone markers in osteoporosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

29 September 2017

Bone density, strength, and formation in adult cathepsin K (-/-) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

29 September 2017

Biomarkers for osteoporosis management: utility in diagnosis, fracture risk prediction and therapy monitoring

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

29 September 2017

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

29 September 2017

Cathepsin K inhibitors: a novel target for osteoporosis therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

29 September 2017

Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

29 September 2017

The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

29 September 2017

Proteinases in bone resorption: obvious and less obvious roles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

29 September 2017

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

29 September 2017

How many women have osteoporosis now?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

29 September 2017

Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two double-blind, randomized, placebo-controlled phase I studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

5 September 2018

The bone lining cell: its role in cleaning Howship's lacunae and initiating bone formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3635595

5 September 2018

Guidelines for diagnosis and management of osteoporosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04471.X

21 January 2018

The collagenolytic activity of cathepsin K is unique among mammalian proteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunochemical characterization of assay for carboxyterminal telopeptide of human type I collagen: loss of antigenicity by treatment with cathepsin K

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basic science and clinical utility of biochemical markers of bone turnover--a Congress report

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidemiology of osteoporosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High bone mineral density in pycnodysostotic patients with a novel mutation in the propeptide of cathepsin K

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin k inhibitor odanacatib: demethylation of a methylsulfonyl moiety as a major metabolic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: the OCEAN study

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative determination of odanacatib in human plasma using liquid–liquid extraction followed by liquid chromatography–tandem mass spectrometry analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2125.2012.04471.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23013236%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

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9 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

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9 March 2020

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