β-Cell lipotoxicity after an overnight intravenous lipid challenge and free fatty acid elevation in African American versus American white overweight/obese adolescents (Q36817206)

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scientific article published on 22 March 2013

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English	β-Cell lipotoxicity after an overnight intravenous lipid challenge and free fatty acid elevation in African American versus American white overweight/obese adolescents	scientific article published on 22 March 2013

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27 February 2020

β-Cell lipotoxicity after an overnight intravenous lipid challenge and free fatty acid elevation in African American versus American white overweight/obese adolescents (English)

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27 February 2020

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Riccardo C Bonadonna

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Sara F Michaliszyn

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Sara F Michaliszyn

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Kara S Hughan

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Silva A Arslanian

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22 March 2013

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27 February 2020

The Journal of Clinical Endocrinology and Metabolism

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27 February 2020

98

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2062-2069

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27 February 2020

Measuring β-cell function relative to insulin sensitivity in youth: does the hyperglycemic clamp suffice?

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29 September 2017

Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies

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Skeletal muscle lipid content and insulin sensitivity in black versus white obese adolescents: is there a race differential?

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29 September 2017

Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus

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Effects of an intravenous lipid challenge and free fatty acid elevation on in vivo insulin sensitivity in African American versus Caucasian adolescents

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In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes?

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29 September 2017

Hyperinsulinemia in African-American adolescents compared with their American white peers despite similar insulin sensitivity: a reflection of upregulated beta-cell function?

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29 September 2017

Measures of beta-cell function during the oral glucose tolerance test, liquid mixed-meal test, and hyperglycemic clamp test.

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29 September 2017

Metabolic abnormalities underlying the different prediabetic phenotypes in obese adolescents

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29 September 2017

Prevention and treatment of type 2 diabetes in youth

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29 September 2017

Youth type 2 diabetes: insulin resistance, beta-cell failure, or both?

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29 September 2017

Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors.

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29 September 2017

Fatty acids, lipotoxicity and insulin secretion

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29 September 2017

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

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29 September 2017

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

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29 September 2017

Modeling beta-cell insulin secretion--implications for closed-loop glucose homeostasis

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27 June 2018

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

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27 June 2018

Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes

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27 June 2018

Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.

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27 June 2018

Plasma free fatty acid turnover rate in obesity

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27 June 2018

Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity.

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5 September 2018

Progression from normal glucose tolerance to type 2 diabetes in a young girl: longitudinal changes in insulin sensitivity and secretion assessed by the clamp technique and surrogate estimates

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5 September 2018

Beta-cell function across the spectrum of glucose tolerance in obese youth

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5 September 2018

Family history of type 2 diabetes is associated with decreased insulin sensitivity and an impaired balance between insulin sensitivity and insulin secretion in white youth

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5 September 2018

Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada: a population at very high risk for developing type 2 diabetes

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5 September 2018

Hyperinsulinemia in african-american children: decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity

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5 September 2018

Acute elevation of NEFA causes hyperinsulinemia without effect on insulin secretion rate in healthy human subjects.

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Glucose-induced insulin hypersecretion in lipid-infused healthy subjects is associated with a decrease in plasma norepinephrine concentration and urinary excretion

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Elevation of plasma fatty acids by ten-hour intralipid infusion has no effect on basal or glucose-stimulated insulin secretion in normal man

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12 December 2020

based on heuristic

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A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23526462

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23526462

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a 48-h fat infusion on insulin secretion and glucose utilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/23526462

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1210/JC.2012-3492

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Europe PubMed Central

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27 February 2020

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27 February 2020

1 reference

Europe PubMed Central

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27 February 2020

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