Nuclear receptor coactivator 1 (Q3681842)

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mammalian protein found in Homo sapiens
  • Protein Hin-2
  • steroid receptor coactivator-1
  • RIP160
  • nuclear receptor coactivator 1
  • NCOA1
  • Hin-2 protein
  • SRC-1
  • bHLHe74
  • class E basic helix-loop-helix protein 74
  • PAX3/NCOA1 fusion protein
  • Steroid receptor coactivator 1
  • renal carcinoma antigen NY-REN-52
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Language Label Description Also known as
English
Nuclear receptor coactivator 1
mammalian protein found in Homo sapiens
  • Protein Hin-2
  • steroid receptor coactivator-1
  • RIP160
  • nuclear receptor coactivator 1
  • NCOA1
  • Hin-2 protein
  • SRC-1
  • bHLHe74
  • class E basic helix-loop-helix protein 74
  • PAX3/NCOA1 fusion protein
  • Steroid receptor coactivator 1
  • renal carcinoma antigen NY-REN-52

Statements

molecular function
protein binding
determination method
IPI
30 references
retrieved
8 April 2019
stated in
2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin
GOA
curator
UniProt
UniProt protein ID
Q15788
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors
GOA
curator
UniProt
UniProt protein ID
Q15788
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation
GOA
curator
UniProt
UniProt protein ID
Q15788
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development
GOA
curator
UniProt
UniProt protein ID
Q15788
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs
GOA
curator
UniProt
UniProt protein ID
Q15788
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors
GOA
curator
UniProt
UniProt protein ID
Q15788
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors
GOA
curator
UniProt
UniProt protein ID
Q15788
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Molecular determinants of the estrogen receptor-coactivator interface
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Tumor suppressor Menin acts as a corepressor of LXRα to inhibit hepatic lipogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRα
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Molecular determinants of the interactions between SRC-1 and LXR/RXR heterodimers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
In vitro farnesoid X receptor ligand sensor assay using surface plasmon resonance and based on ligand-induced coactivator association
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
retrieved
8 April 2019
stated in
The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15788
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE NCOA1 209106 at fs.png
732 × 530; 11 KB
0 references

Identifiers

PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q3681842&oldid=2022904499"