Selective estrogen receptor modulators for postmenopausal osteoporosis: current state of development (Q36822378)

16 August 2017

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title

Selective estrogen receptor modulators for postmenopausal osteoporosis: current state of development (English)

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postmenopausal osteoporosis

16 August 2017

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Luigi Gennari

1

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16 August 2017

Daniela Merlotti

2

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16 August 2017

Fabrizio Valleggi

3

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16 August 2017

Giuseppe Martini

4

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16 August 2017

Ranuccio Nuti

5

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16 August 2017

publication date

1 January 2007

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16 August 2017

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16 August 2017

volume

24

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16 August 2017

issue

5

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16 August 2017

page(s)

361-379

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Association of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older women

16 August 2017

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Crossref

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Comparative effects of estrogen and antiestrogens on differentiation of osteoblasts in mouse bone marrow culture

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Synthesis and pharmacology of conformationally restricted raloxifene analogues: highly potent selective estrogen receptor modulators

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What can be learned from the levormeloxifene experience?

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Effects of anti-estrogens on bone in castrated and intact female rats

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Discovery and synthesis of [6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-(4-hydroxyphenyl)]b enzo[b]thiophene: a novel, highly potent, selective estrogen receptor modulator

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ER beta: identification and characterization of a novel human estrogen receptor

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An estrogen receptor basis for raloxifene action in bone

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Evaluation of the major metabolites of raloxifene as modulators of tissue selectivity

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Arzoxifene: the development and clinical outcome of an ideal SERM.

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Aromatase activity and bone homeostasis in men.

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12 December 2020

LAS, a novel selective estrogen receptor modulator with chemopreventive and therapeutic activity in the N-nitroso-N-methylurea-induced rat mammary tumor model.

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12 December 2020

Clinical review 144: Estrogen and the male skeleton

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Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study

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12 December 2020

Lasofoxifene (Pfizer).

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12 December 2020

LY353381.HCl: a novel raloxifene analog with improved SERM potency and efficacy in vivo

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12 December 2020

Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats

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12 December 2020

Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial

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12 December 2020

Effects of ospemifene (FC-1271a) on uterine endometrium, vaginal maturation index, and hormonal status in healthy postmenopausal women

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12 December 2020

Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators

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12 December 2020

The economic and human costs of osteoporotic fracture

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Axial and appendicular bone density predict fractures in older women

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12 December 2020

Therapeutic potential of oestrogen receptor ligands in development for osteoporosis

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12 December 2020

Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens

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12 December 2020

HRT: what are women (and their doctors) to do?

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A phase II trial of arzoxifene, a selective estrogen response modulator, in patients with recurrent or advanced endometrial cancer

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12 December 2020

Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practice.

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12 December 2020

Cloning of a novel receptor expressed in rat prostate and ovary

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12 December 2020

A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men.

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12 December 2020

Enzyme-catalyzed asymmetric deacylation for the preparation of lasofoxifene (CP-336156), a selective estrogen receptor modulator

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12 December 2020

1,2-Diaryl-3,4-dihydronaphthalenes: photofluorogenic ligands for the estrogen receptor

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12 December 2020

Treatment of established postmenopausal osteoporosis with raloxifene: a randomized trial

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Lasofoxifene: a third-generation selective estrogen receptor modulator for the prevention and treatment of osteoporosis

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12 December 2020

The selective estrogen receptor modulator SCH 57068 prevents bone loss, reduces serum cholesterol and blocks estrogen-induced uterine hypertrophy in ovariectomized rats.

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12 December 2020

Tamoxifen inhibits osteoclast-mediated resorption of trabecular bone in ovarian hormone-deficient rats

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12 December 2020

Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene

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12 December 2020

Comparison of effects of tamoxifen and toremifene on bone biochemistry and bone mineral density in postmenopausal breast cancer patients

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12 December 2020

Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: a double-blind, randomized trial

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12 December 2020

Skeletal effects of raloxifene after 8 years: results from the continuing outcomes relevant to Evista (CORE) study.

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12 December 2020

Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women

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12 December 2020

Long-term dosing of arzoxifene lowers cholesterol, reduces bone turnover, and preserves bone quality in ovariectomized rats

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12 December 2020

Estrogen plus progestin and colorectal cancer in postmenopausal women

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12 December 2020

Lasofoxifene (CP-336,156) protects against the age-related changes in bone mass, bone strength, and total serum cholesterol in intact aged male rats

1 reference

12 December 2020

Randomized, double-blind, multicenter trial comparing two doses of arzoxifene (LY353381) in hormone-sensitive advanced or metastatic breast cancer patients.

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12 December 2020

Ospemifene inhibits the growth of dimethylbenzanthracene-induced mammary tumors in Sencar mice

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12 December 2020

Appendicular bone density and age predict hip fracture in women. The Study of Osteoporotic Fractures Research Group

1 reference

12 December 2020

Dissection of the Molecular Mechanism of Action of GW5638, a Novel Estrogen Receptor Ligand, Provides Insights into the Role of Estrogen Receptor in Bone*

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12 December 2020

Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene

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12 December 2020

Risk-benefit profiles of raloxifene for women

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12 December 2020

Estrogen plus progestin and the risk of coronary heart disease

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12 December 2020

Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ

1 reference

12 December 2020

Effect of ormeloxifene on ovariectomy-induced bone resorption, osteoclast differentiation and apoptosis and TGF beta-3 expression.

1 reference

12 December 2020

Effects of ospemifene, a novel SERM, on vascular markers and function in healthy, postmenopausal women

1 reference

12 December 2020

Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.

1 reference

12 December 2020

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

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12 December 2020

Effects of the new selective estrogen receptor modulator LY353381.HCl (Arzoxifene) on human endometrial cancer growth in athymic mice.

1 reference

12 December 2020

Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity

1 reference

12 December 2020

Femoral fractures in postmenopausal breast cancer patients treated with adjuvant tamoxifen

1 reference

12 December 2020

Choosing between predictors of fractures

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12 December 2020

Estrogen receptors alpha and beta are differentially expressed in developing human bone

1 reference

12 December 2020

Pharmacokinetics of (deaminohydroxy)toremifene in humans: a new, selective estrogen-receptor modulator

1 reference

12 December 2020

Effect of tamoxifen on lumbar spine bone mineral density in postmenopausal women after 5 years

1 reference

12 December 2020

Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists

1 reference

12 December 2020

Molecular basis of agonism and antagonism in the oestrogen receptor

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12 December 2020

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.

1 reference

12 December 2020

Lasofoxifene: a new type of selective estrogen receptor modulator for the treatment of osteoporosis

1 reference

12 December 2020

The ligand binding profiles of estrogen receptors alpha and beta are species dependent

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12 December 2020

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

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12 December 2020

Molecular determinants of tissue selectivity in estrogen receptor modulators

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12 December 2020

In vitro and in vivo biologic effects of Ospemifene (FC-1271a) in breast cancer

1 reference

12 December 2020

SERMs: current status and future trends

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12 December 2020

Adverse events that are associated with the selective estrogen receptor modulator levormeloxifene in an aborted phase III osteoporosis treatment study

1 reference

12 December 2020

Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial

1 reference

12 December 2020

Effects of tamoxifen on spinal bone density in women with breast cancer

1 reference

12 December 2020

Bazedoxifene (Wyeth).

1 reference

12 December 2020

Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial

1 reference

12 December 2020

Genotoxic effects of the novel mixed antiestrogen FC-1271a in comparison to tamoxifen and toremifene

1 reference

12 December 2020

Effects of ospemifene, a novel SERM, on biochemical markers of bone turnover in healthy postmenopausal women

1 reference

12 December 2020

New approaches to the treatment of osteoporosis

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12 December 2020

Perspective. How many women have osteoporosis?

1 reference

12 December 2020

Phase I study of a third-generation selective estrogen receptor modulator, LY353381.HCL, in metastatic breast cancer

1 reference

12 December 2020

Sequence and expression of human estrogen receptor complementary DNA

1 reference

12 December 2020

Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models

1 reference

12 December 2020

Vertebral fractures predict subsequent fractures

1 reference

12 December 2020

Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats

1 reference

12 December 2020

Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer.

1 reference

12 December 2020

Effects of ospemifene and raloxifene on biochemical markers of bone turnover in postmenopausal women

1 reference

12 December 2020

The matrix metalloproteinase system: changes, regulation, and impact throughout the ovarian and uterine reproductive cycle

1 reference

12 December 2020

Long-term treatment of lasofoxifene preserves bone mass and bone strength and does not adversely affect the uterus in ovariectomized rats

1 reference

12 December 2020

Endometrial effects of bazedoxifene acetate, a novel selective estrogen receptor modulator, in postmenopausal women

1 reference

12 December 2020

Differential effects of estrogen and raloxifene on messenger RNA and matrix metalloproteinase 2 activity in the rat uterus

1 reference

12 December 2020

Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer

1 reference

12 December 2020

LY353381 x HCl: an improved benzothiophene analog with bone efficacy complementary to parathyroid hormone-(1-34)

1 reference

12 December 2020

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1 reference

12 December 2020

Selective estrogen receptor modulators as inhibitors of repopulation of human breast cancer cell lines after chemotherapy

1 reference

12 December 2020

Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women

1 reference

12 December 2020

A comparison of women with primary and recurrent pelvic prolapse

1 reference

12 December 2020

Osteoporosis prevention, diagnosis, and therapy

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12 December 2020

Sex steroids and the construction and conservation of the adult skeleton

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12 December 2020

A comparison of the effects of raloxifene and estrogen on bone in postmenopausal women

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12 December 2020

The effect of the new SERM arzoxifene on growth and gene expression in MCF-7 breast cancer cells

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12 December 2020

Breast cancer and hormonal replacement therapy

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12 December 2020

Prevention of bone loss in postmenopausal women treated with lasofoxifene compared with raloxifene

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12 December 2020

Effects of raloxifene, hormone replacement therapy, and placebo on bone turnover in postmenopausal women

1 reference

12 December 2020

Lasofoxifene (CP-336,156), a selective estrogen receptor modulator, prevents bone loss induced by aging and orchidectomy in the adult rat

1 reference

12 December 2020

Comparison of the selective estrogen receptor modulator arzoxifene (LY353381) with tamoxifen on tumor growth and biomarker expression in an MCF-7 human breast cancer xenograft model

1 reference

12 December 2020

Effects of ospemifene and raloxifene on hormonal status, lipids, genital tract, and tolerability in postmenopausal women

1 reference

12 December 2020

2-Phenylindoles. Relationship between structure, estrogen receptor affinity, and mammary tumor inhibiting activity in the rat

1 reference

12 December 2020

10.2165/00002512-200724050-00002

Identifiers

DOI

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Dimensions Publication ID

16 August 2017

1009446052

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