The therapeutic uses of chromatin-modifying agents (Q36822457)

16 August 2017

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title

The therapeutic uses of chromatin-modifying agents (English)

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16 August 2017

Antonello Mai

1

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language of work or name

English

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publication date

1 June 2007

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Expert Opinion on Therapeutic Targets

16 August 2017

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16 August 2017

11

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16 August 2017

6

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16 August 2017

835-851

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Crystal structure of the nucleosome core particle at 2.8 A resolution

16 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

25 years after the nucleosome model: chromatin modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Epigenetics--an epicenter of gene regulation: histones and histone-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

The language of covalent histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Global histone modification patterns predict risk of prostate cancer recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Structure of histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

HDAC6 is a microtubule-associated deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Acetyltransferases and tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Differential roles of p300 and PCAF acetyltransferases in muscle differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Small molecule modulators of histone acetyltransferase p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Inhibition of human immunodeficiency virus type-1 integrase by curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Curcumin inhibits ultraviolet light induced human immunodeficiency virus gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Acetylation of HIV-1 integrase by p300 regulates viral integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Histone deacetylases, transcriptional control, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Histone deacetylases: silencers for hire.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Histone deacetylation in epigenetics: an attractive target for anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Class II histone deacetylases: versatile regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

MEF2: a calcium-dependent regulator of cell division, differentiation and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Control of muscle development by dueling HATs and HDACs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

MEF2-mediated recruitment of class II HDAC at the EBV immediate early gene BZLF1 links latency and chromatin remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

The Sir2 family of protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Histone deacetylase inhibitors: from target to clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Histone Deacetylase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Histone Deacetylase Inhibitors: The Abbott Experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Molecular cloning and characterization of a novel histone deacetylase HDAC10

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Structural Biasing Elements for In-Cell Histone Deacetylase Paralog Selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Antimalarial and antileishmanial activities of aroyl-pyrrolyl-hydroxyamides, a new class of histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Administration of HDAC inhibitors to reactivate HIV-1 expression in latent cellular reservoirs: implications for the development of therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Pharmacological induction of fetal hemoglobin synthesis using histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Induction of human gamma globin gene expression by histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

REELIN and schizophrenia: a disease at the interface of the genome and the epigenome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Identification of a small molecule inhibitor of Sir2p

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

An in silico approach to discovering novel inhibitors of human sirtuin type 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Arginine methylation an emerging regulator of protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Small molecule regulators of protein arginine methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Inhibition of Histone Deacetylase Class I but not Class II Is Critical for the Sensitization of Leukemic Cells to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

Synthesis and Biological Properties of Novel, Uracil-Containing Histone Deacetylase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.835

10.1517/14728222.11.6.835

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17504020