Return to the fetal gene program protects the stressed heart: a strong hypothesis (Q36827885)

16 August 2017

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title

Return to the fetal gene program protects the stressed heart: a strong hypothesis (English)

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16 August 2017

Mitra Rajabi

1

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16 August 2017

Christos Kassiotis

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2

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16 August 2017

Peter Razeghi

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3

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16 August 2017

Heinrich Taegtmeyer

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4

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16 August 2017

1 December 2007

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16 August 2017

Heart Failure Reviews

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16 August 2017

12

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16 August 2017

331-343

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16 August 2017

3-4

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https://scigraph.springernature.com/pub.10.1007/s10741-007-9034-1

16 August 2017

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cites work

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

1 reference

12 December 2020

Load-induced changes in vivo alter substrate fluxes and insulin responsiveness of rat heart in vitro

1 reference

12 December 2020

Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival

1 reference

12 December 2020

Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart

1 reference

12 December 2020

Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes

1 reference

12 December 2020

1 reference

12 December 2020

Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium

1 reference

12 December 2020

Myocardial oxygen and carbohydrate consumption in fetal lambs in utero and in adult sheep

1 reference

12 December 2020

Developmental and functional adaptation of contractile proteins in cardiac and skeletal muscles

1 reference

12 December 2020

Transcripts of alpha-cardiac and alpha-skeletal actins are early markers for myogenesis in the mouse embryo

1 reference

12 December 2020

Ultrastructural changes in rabbit heart mitochondria during the perinatal period. Neonatal transition to aerobic metabolism

1 reference

12 December 2020

Thyroid hormone receptors alpha1 and beta1 are downregulated in the post-infarcted rat heart: consequences on the response to ischaemia-reperfusion

1 reference

12 December 2020

Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia

1 reference

12 December 2020

Development and adaptation of heart mitochondrial respiratory chain function in fetus and in newborn

1 reference

12 December 2020

Energy metabolism of the heart: from basic concepts to clinical applications

1 reference

12 December 2020

Autophagy as mechanism for cell death in degenerative aortic valve disease

1 reference

12 December 2020

Developmental changes in energy substrate use by the heart

1 reference

12 December 2020

Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart

1 reference

12 December 2020

Atrophic remodeling of the transplanted rat heart.

1 reference

12 December 2020

Switching metabolic genes to build a better heart

1 reference

12 December 2020

Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1

1 reference

12 December 2020

Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy.

1 reference

12 December 2020

Re-employment of developmental transcription factors in adult heart disease

1 reference

12 December 2020

Mitochondrial preference for short chain fatty acid oxidation during coronary artery constriction

1 reference

12 December 2020

Myosin heavy chain gene expression in human heart failure

1 reference

12 December 2020

Heart failure in 2001: a prophecy revisited

1 reference

12 December 2020

Streptozotocin-induced changes in cardiac gene expression in the absence of severe contractile dysfunction

1 reference

12 December 2020

Perinatal changes in myocardial supply and flux of fatty acids, carbohydrates, and ketone bodies in lambs

1 reference

12 December 2020

Myocardial substrate metabolism influences left ventricular energetics in vivo

1 reference

12 December 2020

Myocardial hibernation: a delicate balance.

1 reference

12 December 2020

Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness

1 reference

12 December 2020

Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism

1 reference

12 December 2020

Control of cardiac myosin heavy chain gene expression

1 reference

12 December 2020

Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure

1 reference

12 December 2020

Left ventricular assist device and drug therapy for the reversal of heart failure

1 reference

12 December 2020

Signaling pathways responsible for fetal gene induction in the failing human heart: evidence for altered thyroid hormone receptor gene expression

1 reference

12 December 2020

Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity

1 reference

12 December 2020

Role of Akt/protein kinase B in metabolism.

1 reference

12 December 2020

Is the failing heart energy starved? On using chemical energy to support cardiac function

1 reference

12 December 2020

Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases

1 reference

12 December 2020

Thyroid hormone and phenotypes of cardioprotection

1 reference

12 December 2020

Mechanisms of cell survival in myocardial hibernation

1 reference

12 December 2020

Fatty acid oxidation enzyme gene expression is downregulated in the failing heart

1 reference

12 December 2020

Myocytes die by multiple mechanisms in failing human hearts

1 reference

12 December 2020

Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart

1 reference

12 December 2020

Metabolic aspects of programmed cell survival and cell death in the heart

1 reference

12 December 2020

Alterations of the circadian clock in the heart by streptozotocin-induced diabetes

1 reference

12 December 2020

Isomyosin expression in human heart in early pre- and post-natal life

1 reference

12 December 2020

Mitochondrial energy metabolism in heart failure: a question of balance

1 reference

12 December 2020

Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts

1 reference

12 December 2020

Ultrastructural and enzymatic development of fetal guinea pig heart

1 reference

12 December 2020

Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure

1 reference

12 December 2020

Association of gylcogenolysis with cardiac sarcoplasmic reticulum

1 reference

12 December 2020

Dynamic changes of gene expression in hypoxia-induced right ventricular hypertrophy

1 reference

12 December 2020

Transcriptional effects of chronic Akt activation in the heart.

1 reference

12 December 2020

Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms.

1 reference

12 December 2020

Effects of reduced muscle glycogen concentration on force, Ca2+ release and contractile protein function in intact mouse skeletal muscle

1 reference

12 December 2020

Transcriptional regulation of metabolic processes: implications for cardiac metabolism

1 reference

12 December 2020

Human cardiac myosin heavy chain isoforms in fetal and failing adult atria and ventricles

1 reference

12 December 2020

Cardiomyopathy with prominent autophagic degeneration, accompanied by an elevated plasma brain natriuretic peptide level despite the lack of overt heart failure

1 reference

12 December 2020

1 reference

12 December 2020

Myocardial lactate metabolism in fetal and newborn lambs

1 reference

12 December 2020

Regulation of myosin heavy chain genes in the heart

1 reference

12 December 2020

Reverse remodeling of the failing human heart with mechanical unloading. Emerging concepts and unanswered questions

1 reference

12 December 2020

Structural and metabolic correlates of the reversibility of chronic left ventricular ischemic dysfunction in humans

1 reference

12 December 2020

Apoptosis, autophagy, and more

1 reference

12 December 2020

Improved cardiac function with glucose-insulin-potassium after aortocoronary bypass grafting

1 reference

12 December 2020

Volume overload hypertrophy of the newborn heart slows the maturation of enzymes involved in the regulation of fatty acid metabolism

1 reference

12 December 2020

Glucose-insulin-potassium and tri-iodothyronine individually improve hemodynamic performance and are associated with reduced troponin I release after on-pump coronary artery bypass grafting

1 reference

12 December 2020

Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

1 reference

12 December 2020

Perinatal changes in myocardial metabolism in lambs

1 reference

12 December 2020

The role of autophagy during the early neonatal starvation period

1 reference

12 December 2020

Intensive insulin therapy in critically ill patients

1 reference

12 December 2020

p70s6 kinase is a functional target of insulin activated Akt cell-survival signaling

1 reference

12 December 2020

Atrophic Remodeling of the Heart In Vivo Simultaneously Activates Pathways of Protein Synthesis and Degradation

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12 December 2020

Regulation of cardiac hypertrophy by intracellular signalling pathways

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12 December 2020

Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart.

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12 December 2020

Intensive insulin therapy in the medical ICU.

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12 December 2020

A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program

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12 December 2020

Hypertrophy and atrophy of the heart: the other side of remodeling

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12 December 2020

Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

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12 December 2020

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy

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12 December 2020

Increased oxidative metabolism in the fetal and newborn lamb heart

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12 December 2020

An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in Patients with Congestive Heart Failure.

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12 December 2020

Linking gene expression to function: metabolic flexibility in the normal and diseased heart

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12 December 2020

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

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12 December 2020

Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading

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12 December 2020

Regulation of myosin heavy chain and actin isogenes during cardiac growth and hypertrophy.

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12 December 2020

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

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12 December 2020

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

1 reference

12 December 2020

Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium

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12 December 2020

Mitochondria: ignition chamber for apoptosis

1 reference

12 December 2020

Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy

1 reference

12 December 2020

Enhanced preservation of acutely ischemic myocardium and improved clinical outcomes using glucose-insulin-potassium (GIK) solutions

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12 December 2020

O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1.

1 reference

12 December 2020

Cardiac metabolism as a target for the treatment of heart failure

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12 December 2020

Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy.

1 reference

12 December 2020

Ontogeny of malate-aspartate shuttle capacity and gene expression in cardiac mitochondria.

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12 December 2020

Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition

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12 December 2020

Glycolysis is predominant source of myocardial ATP production immediately after birth

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12 December 2020

Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts

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12 December 2020

Abnormal cardiac development in the absence of heart glycogen

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12 December 2020

Regulation of energy metabolism of the heart during acute increase in heart work

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12 December 2020

Downregulation of myocardial myocyte enhancer factor 2C and myocyte enhancer factor 2C-regulated gene expression in diabetic patients with nonischemic heart failure

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12 December 2020

Cardiac hypertrophy: the good, the bad, and the ugly

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12 December 2020

Titin isoform switch in ischemic human heart disease.

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12 December 2020

Cell biology: metabolism meets death

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12 December 2020

Apoptotic versus autophagic cell death in heart failure

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12 December 2020

Lipotoxicity: when tissues overeat

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12 December 2020

Effect of substrate on mitochondrial NADH, cytosolic redox state, and phosphorylated compounds in isolated hearts

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12 December 2020

Metabolic gene expression in fetal and failing human heart

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12 December 2020

The importance of cardiac glycogen for the maintenance of life in foetal lambs and newborn animals during anoxia

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12 December 2020

Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart

1 reference

12 December 2020

PPAR signaling in the control of cardiac energy metabolism

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12 December 2020

Insulin therapy as an adjunct to reperfusion after acute coronary ischemia: a proposed direct myocardial cell survival effect independent of metabolic modulation

1 reference

12 December 2020

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

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12 December 2020

Myocardial Consumption of Oxygen and Carbohydrates in Newborn Sheep

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12 December 2020

Glycogen in the heart--an expanded view

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12 December 2020

Autophagy in chronically ischemic myocardium.

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12 December 2020

Roles of cardiac transcription factors in cardiac hypertrophy

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12 December 2020

Apoptosis in myocytes in end-stage heart failure

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12 December 2020

Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy

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12 December 2020

Medical therapy can improve the biological properties of the chronically failing heart. A new era in the treatment of heart failure

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12 December 2020

Autophagy as a regulated pathway of cellular degradation

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12 December 2020

Improved Left Ventricular Function After Chronic Left Ventricular Unloading

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12 December 2020

Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth

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12 December 2020

Modulation of cardiac function: titin springs into action

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12 December 2020

10.1007/S10741-007-9034-1

Identifiers

DOI

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16 August 2017

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