Molecular "negativity" may underlie multiple sclerosis: role of the myelin basic protein family in the pathogenesis of MS. (Q36832884)

16 August 2017

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title

Molecular "negativity" may underlie multiple sclerosis: role of the myelin basic protein family in the pathogenesis of MS. (English)

1 reference

16 August 2017

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1 reference

George Harauz

2

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author name string

Abdiwahab A Musse

series ordinal

1

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16 August 2017

1 January 2007

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International Review of Neurobiology

16 August 2017

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16 August 2017

79

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16 August 2017

149-172

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Localization of peptidylarginine deiminase type II in a stage-specific immature oligodendrocyte from rat cerebral hemisphere

16 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

A rigorous method for multigenic families' functional annotation: the peptidyl arginine deiminase (PADs) proteins family example

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Reversing histone methylation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Mechanism of demyelination in DM20 transgenic mice involves increased fatty acylation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Molecular dynamics exposes alpha-helices in myelin basic protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Characterization of a Recombinant Murine 18.5-kDa Myelin Basic Protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

An Arg/Lys-->Gln mutant of recombinant murine myelin basic protein as a mimic of the deiminated form implicated in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Membrane-anchoring and charge effects in the interaction of myelin basic protein with lipid bilayers studied by site-directed spin labeling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

An immunodominant epitope of myelin basic protein is an amphipathic alpha-helix

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Biology of oligodendrocyte and myelin in the mammalian central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Cryoelectron microscopy of protein-lipid complexes of human myelin basic protein charge isomers differing in degree of citrullination.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Calcium signal transduction and cellular control mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Calcium - a life and death signal

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The versatility and universality of calcium signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Myelin basic protein: a multifunctional protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Effect of posttranslational modifications to myelin basic protein on its ability to aggregate acidic lipid vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The interaction of basic proteins from normal and multiple sclerosis myelin with phosphatidylglycerol vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The effect of basic myelin protein on multilayer membrane formation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The role of charge microheterogeneity of human myelin basic protein in the formation of phosphatidylglycerol multilayers

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Rapid release and unusual stability of immunodominant peptide 45-89 from citrullinated myelin basic protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French population

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Acylation of myelin basic protein peptide 1-21 with alkyl carboxylates 2-10 carbons long affects secondary structure and posttranslational modification

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Microstructural analysis of the effects of incorporation of myelin basic protein in phospholipid layers

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Characterization of myelin fractions from human brain white matter.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Differences in susceptibility of MBP charge isomers to digestion by stromelysin-1 (MMP-3) and release of an immunodominant epitope.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Binding of human normal and multiple sclerosis-derived myelin basic protein to phospholipid vesicles: effects on membrane head group and bilayer regions.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Intrinsic disorder and protein function

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Glycolipids and transmembrane signaling: antibodies to galactocerebroside cause an influx of calcium in oligodendrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Galactocerebroside and sulfatide independently mediate Ca2+ responses in oligodendrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Myelin basic protein is affected by reduced synthesis of myelin proteolipid protein in the jimpy mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Solution NMR structure of an immunodominant epitope of myelin basic protein. Conformational dependence on environment of an intrinsically unstructured protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

A combinatorial network of evolutionarily conserved myelin basic protein regulatory sequences confers distinct glial-specific phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Axonal damage in acute multiple sclerosis lesions.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The presence of citrulline in a myelin protein fraction

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Natively unfolded proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Why does remyelination fail in multiple sclerosis?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Expression and regulation of golli products of myelin basic protein gene during in vitro development of oligodendrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The thermodynamically stable state of myelin basic protein in aqueous solution is a flexible coil

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Citrullination: a posttranslational modification in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Small angle x-ray scattering from lipid-bound myelin basic protein in solution

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Myelin basic protein-diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Synergistic interactions of lipids and myelin basic protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Genomics, proteomics, metabolomics: what is in a word for multiple sclerosis?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Multiple sclerosis: an important role for post-translational modifications of myelin basic protein in pathogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Epidemiologic evidence for multiple sclerosis as an infection

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Myelin basic protein gene expression in neurons: developmental and regional changes in protein targeting within neuronal nuclei, cell bodies, and processes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Multiple sclerosis: etiological mechanisms and future directions.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish population

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Cells producing antibodies specific for myelin basic protein region 70-89 are predominant in cerebrospinal fluid from patients with multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Molecules affecting myelin stability: a novel hypothesis regarding the pathogenesis of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Demyelination in a transgenic mouse: a model for multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Loss of myelin basic protein cationicity in DM20 transgenic mice is dosage dependent

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Myelin basic protein in experimental allergic encephalomyelitis is not affected at the posttranslational level: implications for demyelinating disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Modifications of myelin basic protein in DM20 transgenic mice are similar to those in myelin basic protein from multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Myelin degeneration in multiple system atrophy detected by unique antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Localization of basic proteins in human myelin.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Myelin in multiple sclerosis is developmentally immature

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Peptidylarginine deiminase: a candidate factor in demyelinating disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Deimination of membrane-bound myelin basic protein in multiple sclerosis exposes an immunodominant epitope

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Comparison of enzymatic properties between hPADI2 and hPADI4

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Neurological mouse mutants and the genes of myelin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Increased citrullinated glial fibrillary acidic protein in secondary progressive multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Expression of citrullinated proteins in murine experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Multiple sclerosis genetics: leaving no stone unturned

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: relationship to the mechanism of myelin repair

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Conformation of bovine myelin basic protein purified with bound lipids

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The developmental expression and activity of peptidylarginine deiminase in the mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Deimination of myelin basic protein. 1. Effect of deimination of arginyl residues of myelin basic protein on its structure and susceptibility to digestion by cathepsin D.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Deimination of Myelin Basic Protein. 2. Effect of Methylation of MBP on Its Deimination by Peptidylarginine Deiminase†

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Citrullination of central nervous system proteins during the development of experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Assessing protein disorder and induced folding

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Multilamellar packing of myelin modeled by lipid-bound MBP

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Increased peptidylarginine deiminase type II in hypoxic astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Fyn tyrosine kinase participates in the compact myelin sheath formation in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Adhesion and clustering of charge isomers of myelin basic protein at model myelin membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Over-expression of the DM-20 myelin proteolipid causes central nervous system demyelination in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Immunology of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The coming of age for antigen-specific therapy of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Major T-cell responses in multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Protein unfolding by peptidylarginine deiminase. Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

PADI4 gene in multiple sclerosis: a family-based association study

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Intrinsically unstructured proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The interplay between structure and function in intrinsically unstructured proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Structural disorder throws new light on moonlighting

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Axonal transection in the lesions of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Exogenous myelin basic protein promotes oligodendrocyte death via increased calcium influx

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Localization and partial characterization of a 60 kDa citrulline-containing transport form of myelin basic protein from MO3-13 cells and human white matter

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Citrullination: a small change for a protein with great consequences for rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

1 reference

7 January 2021

Is the myelin membrane abnormal in multiple sclerosis?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The mighty arginine, the stable quaternary amines, the powerful aromatics, and the aggressive phosphate: their role in the noncovalent minuet

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Amazing stability of the arginine-phosphate electrostatic interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

Multisite protein modification and intramolecular signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

The pathobiology of myelin mutants reveal novel biological functions of the MBP and PLP genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2807%2979007-4

7 January 2021

10.1016/S0074-7742(07)79007-4

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17531841