Tumor hypoxia, DNA repair and prostate cancer progression: new targets and new therapies (Q36839790)

16 August 2017

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title

Tumor hypoxia, DNA repair and prostate cancer progression: new targets and new therapies (English)

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16 August 2017

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Norman Chan

1

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16 August 2017

Michael Milosevic

series ordinal

2

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16 August 2017

Robert G Bristow

series ordinal

3

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16 August 2017

language of work or name

English

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publication date

1 June 2007

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16 August 2017

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16 August 2017

3

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16 August 2017

3

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16 August 2017

329-341

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Optimal treatment of intermediate-risk prostate carcinoma with radiotherapy: clinical and translational issues

16 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Radical prostatectomy, external beam radiotherapy <72 Gy, external beam radiotherapy > or =72 Gy, permanent seed implantation, or combined seeds/external beam radiotherapy for stage T1-T2 prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Dynamics of hypoxia, proliferation and apoptosis after irradiation in a murine tumor model

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Exploiting tumour hypoxia in cancer treatment

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Hypoxia--a key regulatory factor in tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.3.329

The hypoxic tumour microenvironment and metastatic progression

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.3.329

The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Tumor microenvironmental physiology and its implications for radiation oncology

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.3.329

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.3.329

The hypoxic proteome is influenced by gene-specific changes in mRNA translation

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Control of the hypoxic response through regulation of mRNA translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Plasma osteopontin in comparison with bone markers as indicator of bone metastasis and survival outcome in patients with prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Effects of androgen suppression and radiation on prostate cancer suggest a role for angiogenesis blockade.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Lessons from phase III clinical trials on anti-VEGF therapy for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Mechanisms of disease: angiogenesis in urologic malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Expression of vascular endothelial growth factor (VEGF) in locally invasive prostate cancer is prognostic for radiotherapy outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Prostate cancer: evaluation of vascular characteristics with dynamic contrast-enhanced T1-weighted MR imaging--initial experience.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Non-invasive evaluation of tumour hypoxia in the Shionogi tumour model for prostate cancer with 18F-EF5 and positron emission tomography.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Radiation and new molecular agents part I: targeting ATM-ATR checkpoints, DNA repair, and the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

The p53 protein family and radiation sensitivity: Yes or no?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Hypoxia-induced down-regulation of BRCA1 expression by E2Fs.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Prostate cancer epidemiology

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Hypoxia in the androgen-dependent Shionogi model for prostate cancer at three stages.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Incorporating clinical measurements of hypoxia into tumor local control modeling of prostate cancer: implications for the alpha/beta ratio.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Increased radiosensitivity with chronic hypoxia in four human tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Cell cycle progression and radiation survival following prolonged hypoxia and re-oxygenation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Resistance of hypoxic cells to ionizing radiation is influenced by homologous recombination status

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Genetic susceptibility and oxidative stress in prostate cancer: integrated model with implications for prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

An immunohistochemical assessment of hypoxia in prostate carcinoma using pimonidazole: Implications for radioresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

Defective DNA Strand Break Repair after DNA Damage in Prostate Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.3.329

21 January 2018

Identifiers

DOI

10.2217/14796694.3.3.329

1 reference

16 August 2017

1 reference