Development and progression of secondary hyperparathyroidism in chronic kidney disease: lessons from molecular genetics (Q36849325)

16 August 2017

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title

Development and progression of secondary hyperparathyroidism in chronic kidney disease: lessons from molecular genetics (English)

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chronic renal insufficiency

16 August 2017

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secondary hyperparathyroidism

inferred from title

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William G Goodman

1

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16 August 2017

L D Quarles

series ordinal

2

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16 August 2017

language of work or name

English

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publication date

13 June 2007

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16 August 2017

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16 August 2017

74

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16 August 2017

3

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16 August 2017

276-288

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https://scigraph.springernature.com/pub.10.1038/sj.ki.5002287

16 August 2017

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The severity of secondary hyperparathyroidism in chronic renal insufficiency is GFR-dependent, race-dependent, and associated with cardiovascular disease

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Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease

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Parathyroidectomy rates among United States dialysis patients: 1990-1999.

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Abnormal regulation of parathyroid hormone release by calcium in secondary hyperparathyroidism due to chronic renal failure

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Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells

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Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D.

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Clonal analysis of nodular parathyroid hyperplasia in renal hyperparathyroidism

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7 January 2021

Molecular genetics of hyperparathyroid disease.

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7 January 2021

Role of the calcium-sensing receptor in parathyroid gland physiology

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7 January 2021

Bone mineral density and biochemical markers of bone turnover in patients with predialysis chronic renal failure

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7 January 2021

Effect of 18 months of treatment with alfacalcidol on bone in patients with mild to moderate chronic renal failure

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7 January 2021

Bone mineral density measurements in dialysis patients

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7 January 2021

Racial differences in bone mineral density and bone loss among end-stage renal disease patients

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7 January 2021

Increased risk of hip fracture among patients with end-stage renal disease

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7 January 2021

A calcimimetic agent lowers plasma parathyroid hormone levels in patients with secondary hyperparathyroidism

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7 January 2021

The calcimimetic AMG 073 reduces parathyroid hormone and calcium x phosphorus in secondary hyperparathyroidism

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7 January 2021

The fall and rise of parathyroidectomy in U.S. hemodialysis patients, 1992 to 2002.

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7 January 2021

Calcimimetics: a remedy for all problems of excess parathyroid hormone activity in chronic kidney disease?

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7 January 2021

Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid

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7 January 2021

Extracellular calcium sensing and extracellular calcium signaling

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7 January 2021

Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3

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7 January 2021

Phosphorus accelerates the development of parathyroid hyperplasia and secondary hyperparathyroidism in rats with renal failure

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7 January 2021

Episodic fluctuation in serum intact parathyroid hormone concentration in men

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7 January 2021

Calcium and phosphorus metabolism in patients who have chronic kidney disease

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7 January 2021

The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. Part I of IV parts: mechanisms of calcium transfer between blood and bone and their cellular basis: morphological a

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7 January 2021

The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone diseases. II. PTH and bone cells: bone turnover and plasma calcium regulation

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7 January 2021

Parathyroid hormone secretion in vivo. Demonstration of a calcium-independent nonsuppressible component of secretion

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7 January 2021

Direct in vivo assessment of parathyroid hormone-calcium relationship curve in renal patients

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7 January 2021

The set point of parathyroid hormone stimulation by calcium is normal in progressive renal failure

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7 January 2021

Conserved mechanism of negative gene regulation by extracellular calcium. Parathyroid hormone gene versus atrial natriuretic polypeptide gene

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7 January 2021

Regulation of Parathyroid Hormone Secretion: Proportional Control by Calcium, Lack of Effect of Phosphate1

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7 January 2021

Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

RNA-Protein binding and post-transcriptional regulation of parathyroid hormone gene expression by calcium and phosphate

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells

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7 January 2021

Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase

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7 January 2021

Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells

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7 January 2021

Regulation of 1,25-dihydroxyvitamin D3 by calcium in the parathyroidectomized, parathyroid hormone-replete rat.

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7 January 2021

Two vitamin D3-dependent calcium binding proteins increase calcium reabsorption by different mechanisms. II. Effect of CaBP 9K

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7 January 2021

Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice

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7 January 2021

Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney.

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7 January 2021

Effects of vitamin D compounds on renal and intestinal Ca2+ transport proteins in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice

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7 January 2021

Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia.

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7 January 2021

Is vitamin D indispensable for Ca2+ homeostasis: lessons from knockout mouse models?

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7 January 2021

Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+.

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

ECaC: the gatekeeper of transepithelial Ca2+ transport

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

The renal PTH/PTHrP receptor is down-regulated in rats with chronic renal failure

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Skeletal resistance to parathyroid hormone in renal failure. Studies in 105 human subjects.

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in ESRD patients

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Administration of PTH-(7-84) antagonizes the effects of PTH-(1-84) on bone in rats with moderate renal failure.

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Synthetic carboxyl-terminal fragments of parathyroid hormone (PTH) decrease ionized calcium concentration in rats by acting on a receptor different from the PTH/PTH-related peptide receptor

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Dietary phosphate and parathyroid hormone alter the expression of the calcium-sensing receptor (CaR) and the Na+-dependent Pi transporter (NaPi-2) in the rat proximal tubule.

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Extracellular calcium-sensing receptors in the parathyroid gland, kidney, and other tissues

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Medical control of secondary hyperparathyroidism: we're not there yet

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

On the prevention of secondary hyperparathyroidism in experimental chronic renal disease using “proportional reduction” of dietary phosphorus intake

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

The role of phosphorus restriction in the prevention of secondary hyperparathyroidism in chronic renal disease

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Pathogenesis of secondary hyperparathyroidism

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

On the mechanism of secondary hyperparathyroidism in moderate renal insufficiency

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Hypocalcemia may not be essential for the development of secondary hyperparathyroidism in chronic renal failure

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Elevations of serum phosphorus and potassium in mild to moderate chronic renal insufficiency

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

p21(WAF1) and transforming growth factor-alpha mediate dietary phosphate regulation of parathyroid cell growth

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1alpha-hydroxylase gene expression in the proximal renal tubule

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Circulating vitamin D metabolite concentrations in childhood renal diseases

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Calcium Metabolism in Early Chronic Renal Failure: Implications for the Pathogenesis of Hyperparathyroidism

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men.

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Vitamin D biosynthesis and vitamin D 1 alpha-hydroxylase deficiency

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Vitamin D insufficiency and deficiency in chronic kidney disease. A single center observational study

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Redefining vitamin D insufficiency

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

The physicochemical state and renal handling of divalent ions in chronic renal failure

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Divalent Ion Excretion in Chronic Kidney Disease: Relation to Degree of Renal Insufficiency

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Effect of phosphate on parathyroid hormone secretion in vivo.

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Mechanisms of secondary hyperparathyroidism

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Parathyroid hormone gene expression in hypophosphatemic rats

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Hyperplasia of the parathyroid gland without secondary hyperparathyroidism

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

De novo expression of transforming growth factor-alpha in parathyroid gland tissue of patients with primary or secondary uraemic hyperparathyroidism

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

1,25-Dihydroxyvitamin D downregulation of TGFalpha/EGFR expression and growth signaling: a mechanism for the antiproliferative actions of the sterol in parathyroid hyperplasia of renal failure

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7 January 2021

Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.

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7 January 2021

Calcitriol therapy and calcium-regulated PTH secretion in patients with secondary hyperparathyroidism

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7 January 2021

Calcium-regulated parathyroid hormone secretion in adynamic renal osteodystrophy

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Calcium-regulated parathyroid hormone release in patients with mild or advanced secondary hyperparathyroidism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Suppressive effect of calcium on parathyroid hormone release in adynamic renal osteodystrophy and secondary hyperparathyroidism

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Non-suppressible parathyroid hormone secretion is related to gland size in uremic secondary hyperparathyroidism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Calcium-regulated parathyroid hormone release in primary hyperparathyroidism: studies in vitro with dispersed parathyroid cells

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Abnormal calcium-regulated PTH release in normal parathyroid tissue from patients with adenoma

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice.

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7 January 2021

Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hyperparathyroidism

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7 January 2021

Experimental Model for Hyperparathyroidism: Effect of Excessive Numbers of Transplanted Isologous Parathyroid Glands

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7 January 2021

1,25(OH)2 vitamin D3 inhibits parathyroid cell proliferation in experimental uremia

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7 January 2021

A dual block to cell cycle progression in HL60 cells exposed to analogues of vitamin D3

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Vitamin D regulated keratinocyte differentiation: role of coactivators

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Vitamin D compounds. Effect on clonal proliferation and differentiation of human myeloid cells

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7 January 2021

Reduced binding of [3H]1,25-dihydroxyvitamin D3 in the parathyroid glands of patients with renal failure

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients.

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

1,25-(OH)2D receptors are decreased in parathyroid glands from chronically uremic dogs

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice

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7 January 2021

Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Modulation of 1alpha,25-dihydroxyvitamin D3-membrane associated, rapid response steroid binding protein expression in mouse odontoblasts by 1alpha,25-(OH)2D3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS)-binding protein in rat IEC-6 cells

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Evidence for a bone-kidney axis regulating phosphate homeostasis

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

1 reference

7 January 2021

Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Regulation of fibroblast growth factor-23 signaling by klotho

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism

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https://api.crossref.org/works/10.1038%2FSJ.KI.5002287

7 January 2021

Identifiers

DOI

10.1038/SJ.KI.5002287

1 reference

Dimensions Publication ID

16 August 2017

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1 reference