Xenotransplantation: current status and a perspective on the future (Q36850147)

16 August 2017

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title

Xenotransplantation: current status and a perspective on the future (English)

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16 August 2017

Yong-Guang Yang

1

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16 August 2017

Megan Sykes

series ordinal

2

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16 August 2017

publication date

1 July 2007

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Nature Reviews Immunology

16 August 2017

published in

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16 August 2017

volume

7

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16 August 2017

issue

7

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16 August 2017

page(s)

519-531

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The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene.

16 August 2017

cites work

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Genetically modified HLA class I molecules able to inhibit human NK cells without provoking alloreactive CD8+ CTLs

21 January 2018

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Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D.

21 January 2018

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Porcine UL16-binding protein 1 expressed on the surface of endothelial cells triggers human NK cytotoxicity through NKG2D.

21 January 2018

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Both gamma delta T cells and NK cells inhibit the engraftment of xenogeneic rat bone marrow cells and the induction of xenograft tolerance in mice.

21 January 2018

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Human monocytes recognize porcine endothelium via the interaction of galectin 3 and alpha-GAL.

21 January 2018

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T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts

21 January 2018

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Accommodation: preventing injury in transplantation and disease

21 January 2018

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Transplantation tolerance and autoimmunity after xenogeneic thymus transplantation

21 January 2018

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Pathogenesis of autoimmunity after xenogeneic thymus transplantation.

21 January 2018

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NK cell tolerance in mixed allogeneic chimeras

21 January 2018

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Will the pig solve the transplantation backlog?

21 January 2018

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Transplantation of porcine fetal pancreas to diabetic patients

31 March 2020

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Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation

31 March 2020

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Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways

31 March 2020

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Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates

31 March 2020

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Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans

31 March 2020

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Pathology of xenograft rejection: a commentary

31 March 2020

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Decay-accelerating factor prevents acute humoral rejection induced by low levels of anti-alphaGal natural antibodies

31 March 2020

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T-cell responses during pig-to-primate xenotransplantation.

31 March 2020

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Prevention of Hyperacute Rejection in a Model of Orthotopic Liver Xenotransplantation From Pig to Baboon Using Polytransgenic Pig Livers (CD55, CD59, and H-Transferase)

31 March 2020

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Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity

31 March 2020

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Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts.

31 March 2020

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Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

31 March 2020

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Intravascular thrombosis in discordant xenotransplantation.

31 March 2020

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Intraportal pig islet xenotransplantation into athymic mice as an in vivo model for the study of the instant blood-mediated inflammatory reaction

31 March 2020

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Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids

31 March 2020

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Pig cells that lack the gene for alpha1-3 galactosyltransferase express low levels of the gal antigen

31 March 2020

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Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience

31 March 2020

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Lysosomal glycosphingolipid recognition by NKT cells

31 March 2020

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Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population

31 March 2020

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Cardiac xenotransplantation: recent preclinical progress with 3-month median survival

31 March 2020

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31 March 2020

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Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity

31 March 2020

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Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis.

31 March 2020

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Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161)

31 March 2020

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Importance of natural killer cells in the rejection of hamster skin xenografts

31 March 2020

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Elimination of porcine hemopoietic cells by macrophages in mice

31 March 2020

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Clearance of mobilized porcine peripheral blood progenitor cells is delayed by depletion of the phagocytic reticuloendothelial system in baboons

31 March 2020

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Antibody- and complement-independent phagocytotic and cytolytic activities of human macrophages toward porcine cells

31 March 2020

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T cell independence of macrophage and natural killer cell infiltration, cytokine production, and endothelial activation during delayed xenograft rejection

31 March 2020

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Terminal sialic acid residues on human glycophorin A are recognized by porcine kupffer cells

31 March 2020

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Attenuation of phagocytosis of xenogeneic cells by manipulating CD47.

31 March 2020

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Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages

31 March 2020

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Role of CD47 as a marker of self on red blood cells

31 March 2020

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Human neutrophil gene expression profiling following xenogeneic encounter with porcine aortic endothelial cells: the occult role of neutrophils in xenograft rejection revealed.

31 March 2020

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Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine

31 March 2020

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Microchimerism and transmission of porcine endogenous retrovirus from a pig cell line or specific pathogen-free pig islets to mouse tissues and human cells during xenografts in nude mice

31 March 2020

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Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice

31 March 2020

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Monitoring for potentially xenozoonotic viruses in New Zealand pigs

31 March 2020

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Xenotransplantation: past achievements and future promise.

31 March 2020

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Long-Term Survival of Hamster Hearts in Presensitized Rats

31 March 2020

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Accommodation after lung xenografting from hamster to rat.

31 March 2020

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The role of anti-Galalpha1-3Gal antibodies in acute vascular rejection and accommodation of xenografts

31 March 2020

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Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation

31 March 2020

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Warfarin or low-molecular-weight heparin therapy does not prolong pig-to-primate cardiac xenograft function

31 March 2020

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Effects of Long-term Administration of High-dose Recombinant Human Antithrombin in Immunosuppressed Primate Recipients of Porcine Xenografts

31 March 2020

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Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation

31 March 2020

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Recombinant adenoviral mediated CD39 gene transfer prolongs cardiac xenograft survival

31 March 2020

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Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation

31 March 2020

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Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.

31 March 2020

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Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis.

31 March 2020

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Reduction in the level of Gal(alpha1,3)Gal in transgenic mice and pigs by the expression of an alpha(1,2)fucosyltransferase

31 March 2020

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Fucosyl transferase (H) transgenic heart transplants to Gal-/- mice

31 March 2020

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Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning.

31 March 2020

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Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs

31 March 2020

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Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations

31 March 2020

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Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

31 March 2020

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Tolerization of anti-Galalpha1-3Gal natural antibody-forming B cells by induction of mixed chimerism

31 March 2020

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Mixed chimerism induced without lethal conditioning prevents T cell- and anti-Gal alpha 1,3Gal-mediated graft rejection

31 March 2020

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T cell and B cell tolerance to GALalpha1,3GAL-expressing heart xenografts is achieved in alpha1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism

31 March 2020

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Differing mechanisms of early and late B cell hyporesponsiveness induced by mixed chimerism

31 March 2020

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B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells

31 March 2020

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Inhibition of xenoreactive natural antibody production by retroviral gene therapy

31 March 2020

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Tolerance induction by lentiviral gene therapy with a nonmyeloablative regimen

31 March 2020

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Effects of leflunomide and deoxyspergualin in the guinea pig-->rat cardiac model of delayed xenograft rejection: suppression of B cell and C-C chemokine responses but not induction of macrophage lectin

31 March 2020

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Induction of specific transplantation tolerance across xenogeneic barriers in the T-independent immune compartment

31 March 2020

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Effects of a short course of leflunomide on T-independent B-lymphocyte xenoreactivity and on susceptibility of xenografts to acute or chronic rejection

31 March 2020

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Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation

31 March 2020

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ABO-incompatible allotransplantation as a basis for clinical xenotransplantation

31 March 2020

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Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen

31 March 2020

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Prevention, detection, and management of early bacterial and fungal infections in a preclinical cardiac xenotransplantation model that achieves prolonged survival

31 March 2020

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Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates: proof of concept

31 March 2020

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The bioartificial pancreas: progress and challenges

31 March 2020

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Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: a 4-year study

31 March 2020

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Islet xenotransplantation clinical trial: does histology show islet cells?

31 March 2020

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Xenotransplantation of pig islets into Mexican children: were the fundamental ethical requirements to proceed with such a study really met?

31 March 2020

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Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells

31 March 2020

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Donor lymphocyte infusion induces long-term donor-specific cardiac xenograft survival through activation of recipient double-negative regulatory T cells

31 March 2020

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Specific tolerance across a discordant xenogeneic transplantation barrier

31 March 2020

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Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: evidence for failure of regulatory mechanisms suppressing autoimmunity

31 March 2020

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Skin graft tolerance across a discordant xenogeneic barrier

31 March 2020

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Xenogeneic thymus transplantation in a pig-to-baboon model

31 March 2020

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Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness

31 March 2020

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Vascularized thymic lobe transplantation in a pig-to-baboon model: a novel strategy for xenogeneic tolerance induction and T-cell reconstitution

31 March 2020

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Mixed chimerism and transplant tolerance

31 March 2020

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Mixed chimerism and transplantation tolerance

31 March 2020

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Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier

31 March 2020

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Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers

31 March 2020

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Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism

31 March 2020

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Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation

31 March 2020

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Anti-CD40L monoclonal antibodies can replace anti-CD4 monoclonal antibodies for the nonmyeloablative induction of mixed xenogeneic chimerism

31 March 2020

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Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses.

31 March 2020

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Long-term survival of xenogeneic heart grafts achieved by costimulatory blockade and transient mixed chimerism.

31 March 2020

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Position Paper of the Ethics Committee of the International Xenotransplantation Association

31 March 2020

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Commentary: World Health Assembly resolution 57.18 on xenotransplantation

31 March 2020

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Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance

31 March 2020

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Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology

31 March 2020

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Bone marrow transplantation from alpha1,3-galactosyltransferase gene-knockout pigs in baboons

31 March 2020

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Brief report: treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation

31 March 2020

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The use of a pig liver xenograft for temporary support of a patient with fulminant hepatic failure

31 March 2020

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Prolonged survival of porcine hepatocytes in cynomolgus monkeys

31 March 2020

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Cardiac failure: mechanical support strategies

31 March 2020

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Report of the first U.S. patient successfully supported long term with the LionHeart completely implantable left ventricular assist device system

31 March 2020

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Developments towards an artificial kidney

31 March 2020

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Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure

31 March 2020

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Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial

31 March 2020

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Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial

31 March 2020

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Stem cells--potential for repairing damaged lungs and growing human lungs for transplant

31 March 2020

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31 March 2020

Cardiac regeneration.

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Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg

31 March 2020

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7 January 2021

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Identifiers

DOI

10.1038/NRI2099

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Dimensions Publication ID

16 August 2017

1036221043

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Fatcat ID

release_xkxkmr5dybbmjnumvncxsbyw54

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Fatcat

https://api.fatcat.wiki/v0/release/xkxkmr5dybbmjnumvncxsbyw54

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24 November 2022

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