Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis. (Q36858159)

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scientific article published on June 2008

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English	Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.	scientific article published on June 2008

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8 January 2020

Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis (English)

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apoptotic process

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Viktor R Drel

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Pal Pacher

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Tayyeba K Ali

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Jeho Shin

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Ulrich Julius

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Azza B El-Remessy

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Irina G Obrosova

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1 June 2008

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International Journal of Molecular Medicine

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667-676

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describes a project that uses

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Evaluation of the peroxynitrite decomposition catalyst Fe(III) tetra-mesitylporphyrin octasulfonate on peripheral neuropathy in a mouse model of type 1 diabetes.

1 reference

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Oxidative stress and endothelial dysfunction in vascular disease

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The role of protein kinase C activation and the vascular complications of diabetes

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Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy

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Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells

1 reference

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Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.

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Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications

1 reference

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Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

1 reference

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Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options

1 reference

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29 September 2017

Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527815

29 September 2017

Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst

1 reference

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Lipid inflammatory mediators in diabetic vascular disease

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29 September 2017

A new view of diabetic retinopathy: a neurodegenerative disease of the eye.

1 reference

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29 September 2017

Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst

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How does glucose generate oxidative stress in peripheral nerve?

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Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro

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Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin

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Protein kinase C activation and the development of diabetic complications

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Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens

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29 September 2017

Effects of a Novel Aldose Reductase Inhibitor, Fidarestat (SNK-860), on Vibration Perception Threshold and Subjective Symptoms in Patients with Diabetic Polyneuropathy : An Open-Label Pilot Study

1 reference

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27 June 2018

Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration

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27 June 2018

Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity

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27 June 2018

Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy

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27 June 2018

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

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27 June 2018

Cataract prevention in diabetic Octodon degus with Pfizer's sorbinil.

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27 June 2018

Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats.

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4 September 2018

Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice.

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4 September 2018

Effects of topical administration of an aldose reductase inhibitor on cataract formation in dogs fed a diet high in galactose.

1 reference

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4 September 2018

A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy.

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4 September 2018

Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes.

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4 September 2018

Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.

1 reference

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4 September 2018

Effects of the peroxynitrite decomposition catalyst, FeTMPyP, on function of corpus cavernosum from diabetic mice.

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4 September 2018

Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527815

4 September 2018

Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527815

4 September 2018

Effects of aldose reductase inhibitors and galactose withdrawal on fluorescein angiographic lesions in galactose-fed dogs

1 reference

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4 September 2018

The inhibitory effect of aldose reductase inhibitor for proliferation in the lens epithelial cells of rat sugar cataract

1 reference

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4 September 2018

Long-term treatment with fidarestat suppresses the development of diabetic retinopathy in STZ-induced diabetic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527815

4 September 2018

High glucose-induced tyrosine nitration in endothelial cells: role of eNOS uncoupling and aldose reductase activation

1 reference

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4 September 2018

The role of polyol pathway in glucose-induced apoptosis of cultured retinal pericytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527815

4 September 2018

Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527815

4 September 2018

An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527815

4 September 2018

Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527815

4 September 2018

Enhancement of glucose transport by vascular endothelial growth factor in retinal endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2527815

4 December 2018

Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for poly(ADP-ribose) polymerase activation in diabetic nephropathy, neuropathy and retinopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downregulation of the human taurine transporter by glucose in cultured retinal pigment epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetic-like retinopathy: early and late intervention therapies in galactose-fed rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

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Effects of poly(ADP-ribose) polymerase inhibition on dysfunction of non-adrenergic non-cholinergic neurotransmission in gastric fundus in diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione depletion in the lens of galactosemic and diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of dietary taurine supplementation on GSH and NAD(P)-redox status, lipid peroxidation, and energy metabolism in diabetic precataractous lens

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aldose reductase inhibitors: therapeutic implications for diabetic complications

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cataracts and reduced fertility in degus (Octodon degus). Contracts secondary to spontaneous diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of an aldose reductase inhibitor on lens metabolism, ATPases and antioxidative defense in streptozotocin-diabetic rats: an intervention study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18506358

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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8 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18506358%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

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