Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment. (Q36861965)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22186138%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment (English)

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19 January 2020

8

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19 January 2020

13

David Piwnica-Worms

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19 January 2020

author name string

Emanuela Heller

1

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19 January 2020

Michelle A Hurchla

2

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19 January 2020

Jingyu Xiang

3

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19 January 2020

Xinming Su

4

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19 January 2020

Sara Chen

5

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19 January 2020

Jochen Schneider

6

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19 January 2020

Kyu-Sang Joeng

7

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19 January 2020

Leah Goldberg

9

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19 January 2020

Hongju Deng

10

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19 January 2020

Mary C Hornick

11

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19 January 2020

Julie L Prior

12

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19 January 2020

Fanxin Long

14

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19 January 2020

Ross Cagan

15

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19 January 2020

Katherine N Weilbaecher

16

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19 January 2020

language of work or name

English

0 references

publication date

20 December 2011

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19 January 2020

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19 January 2020

volume

72

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19 January 2020

issue

4

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19 January 2020

page(s)

897-907

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Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells.

19 January 2020

cites work

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Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer.

29 September 2017

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Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells

29 September 2017

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Cancer to bone: a fatal attraction

29 September 2017

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Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

29 September 2017

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TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling

29 September 2017

1 reference

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Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysis

29 September 2017

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Vismodegib, a small-molecule inhibitor of the hedgehog pathway for the treatment of advanced cancers

29 September 2017

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New developments in the discovery of small molecule Hedgehog pathway antagonists

29 September 2017

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Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit.

29 September 2017

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

29 September 2017

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Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

29 September 2017

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

29 September 2017

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CD47 regulates bone mass and tumor metastasis to bone

29 September 2017

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Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

29 September 2017

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Hedgehog signaling in development and cancer.

29 September 2017

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A paracrine requirement for hedgehog signalling in cancer

29 September 2017

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Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo).

29 September 2017

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Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins

29 September 2017

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Essential role of stromally induced hedgehog signaling in B-cell malignancies

29 September 2017

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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

29 September 2017

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Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone

29 September 2017

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29 September 2017

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The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells

29 September 2017

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Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer

29 September 2017

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CXCR4 regulates growth of both primary and metastatic breast cancer

29 September 2017

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Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

29 September 2017

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Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton

29 September 2017

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Prospective identification of tumorigenic breast cancer cells

29 September 2017

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Developmental roles and clinical significance of hedgehog signaling

29 September 2017

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Sonic hedgehog is involved in osteoblast differentiation by cooperating with BMP-2.

29 September 2017

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Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

29 September 2017

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The Hedgehog and Wnt signalling pathways in cancer

29 September 2017

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Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

29 September 2017

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Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation

29 September 2017

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Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis

29 September 2017

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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

29 September 2017

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Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity

29 September 2017

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Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

27 June 2018

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p63 correlates with both BRCA1 and cytokeratin 5 in invasive breast carcinomas: further evidence for the pathogenesis of the basal phenotype of breast cancer.

27 June 2018

1 reference

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Basal cell carcinomas in mice overexpressing sonic hedgehog

27 June 2018

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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

27 June 2018

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The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptor-negative breast cancer.

4 September 2018

1 reference

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Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.

4 September 2018

1 reference

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Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure

4 September 2018

1 reference

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Patching the gaps in Hedgehog signalling

4 September 2018

1 reference

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Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

4 September 2018

1 reference

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Comparison of the effects of intermittent and continuous administration of human parathyroid hormone(1?34) on rat bone

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22186138

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-11-2681

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22186138%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22186138%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

22186138

1 reference