Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion (Q36867528)

16 August 2017

Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion (English)

1 reference

16 August 2017

1 reference

Michelle E Kimple

1

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16 August 2017

Mark P Keller

2

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16 August 2017

Mary R Rabaglia

3

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16 August 2017

Renee L Pasker

4

1 reference

16 August 2017

Joshua C Neuman

5

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16 August 2017

Nathan A Truchan

6

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16 August 2017

Harpreet K Brar

7

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16 August 2017

Alan D Attie

8

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16 August 2017

language of work or name

English

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publication date

24 January 2013

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16 August 2017

9

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inferred from page(s)

published in

Diabetes

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16 August 2017

62

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16 August 2017

6

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16 August 2017

1904-1912

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

16 August 2017

start time

27 August 2021

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1β-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets

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Flow-induced prostaglandin E2 release regulates Na and K transport in the collecting duct

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Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass

29 September 2017

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Comparison of liraglutide versus other incretin-related anti-hyperglycaemic agents

29 September 2017

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Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion

29 September 2017

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FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation

29 September 2017

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Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins

29 September 2017

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A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility

29 September 2017

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Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo.

29 September 2017

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Galphaz negatively regulates insulin secretion and glucose clearance

29 September 2017

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Night eating and obesity in the EP3R-deficient mouse

29 September 2017

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Mechanisms of action of glucagon-like peptide 1 in the pancreas

29 September 2017

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The genetic landscape of type 2 diabetes in mice

29 September 2017

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Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice

29 September 2017

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Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists.

29 September 2017

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Glucose-induced regulation of COX-2 expression in human islets of Langerhans

29 September 2017

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Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

29 September 2017

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Exendin-(9-39) is an inverse agonist of the murine glucagon-like peptide-1 receptor: implications for basal intracellular cyclic adenosine 3',5'-monophosphate levels and beta-cell glucose competence

29 September 2017

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Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells

29 September 2017

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Mechanisms of inhibition of insulin release

29 September 2017

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Transcriptional glucose signaling through the glucose response element is mediated by the pentose phosphate pathway.

29 September 2017

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Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals

29 September 2017

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Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells

29 September 2017

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Molecular mechanisms of diverse actions of prostanoid receptors

29 September 2017

1 reference

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Prostaglandins, Glucose Homeostasis, and Diabetes Mellitus

29 September 2017

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Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype

29 September 2017

1 reference

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Coupling of hepatic prostaglandin receptors to adenylate cyclase through a pertussis toxin sensitive guanine nucleotide regulatory protein

29 September 2017

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The role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhans

29 September 2017

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Down-regulation of prostaglandin E receptors and homologous desensitization of isolated adipocytes

27 June 2018

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Prostaglandin E2-prostanoid EP3 signal induces vascular contraction via nPKC and ROCK activation in rat mesenteric artery.

27 June 2018

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The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice

4 September 2018

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Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes.

4 September 2018

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Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus.

4 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661627

Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced glycation endproduct-specific receptor (AGER), and in islets from diabetic mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661627

Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661627

Regulation of PGE(2) and PGI(2) release from human umbilical vein endothelial cells by actin cytoskeleton

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661627

Cell-specific coupling of PGE2 to different transduction pathways in arginine vasopressin- and glucagon-sensitive segments of the rat renal tubule

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661627

Comparison between two classes of selective EP(3) antagonists and their biological activities

4 September 2018

1 reference

12 December 2020

Improvement of Insulin Secretion in Diabetics by a Prostaglandin Synthesis Inhibitor

1 reference

12 December 2020

PGE2-induced desensitization of adenylate cyclase of a murine macrophage-like cell line (P388D1)

1 reference

12 December 2020

Prostaglandin-dependent desensitization of human monocyte cAMP responses

1 reference

12 December 2020

Two isoforms of prostaglandin E receptor EP3 subtype. Different COOH-terminal domains determine sensitivity to agonist-induced desensitization

1 reference

12 December 2020

Signal transductions of three isoforms of mouse prostaglandin E receptor EP3 subtype

1 reference

12 December 2020

Evidence that glucagon stimulates insulin secretion through its own receptor in rats

1 reference

12 December 2020

Prostaglandin E receptor EP3gamma isoform, with mostly full constitutive Gi activity and agonist-dependent Gs activity

1 reference

12 December 2020

Dominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesis

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB12-0769

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16 August 2017

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16 August 2017

1 reference