Using the past to inform the future: anti-VEGF therapy as a road map to develop novel therapies for diabetic retinopathy (Q36867626)

16 August 2017

Using the past to inform the future: anti-VEGF therapy as a road map to develop novel therapies for diabetic retinopathy (English)

1 reference

16 August 2017

1 reference

Paul M Titchenell

1

1 reference

PMCID

3661651

16 August 2017

David A Antonetti

series ordinal

2

1 reference

PMCID

3661651

16 August 2017

language of work or name

English

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publication date

1 June 2013

1 reference

16 August 2017

8

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inferred from page(s)

published in

Diabetes

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16 August 2017

62

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16 August 2017

6

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16 August 2017

1808-1815

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

16 August 2017

start time

27 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis

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TNF-α signals through PKCζ/NF-κB to alter the tight junction complex and increase retinal endothelial cell permeability

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29 September 2017

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Ranibizumab for macular edema following branch retinal vein occlusion: six-month primary end point results of a phase III study

29 September 2017

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Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study

29 September 2017

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Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family

29 September 2017

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A review of clinical trials of anti-VEGF agents for diabetic retinopathy

29 September 2017

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Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

29 September 2017

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Diabetic macular oedema and visual loss: relationship to location, severity and duration

29 September 2017

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Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (

29 September 2017

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Bevacizumab (Avastin) for the treatment of ocular disease

29 September 2017

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Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells

29 September 2017

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Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy

29 September 2017

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Erythropoietin deficiency decreases vascular stability in mice.

29 September 2017

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29 September 2017

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IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development

29 September 2017

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Laser treatment in diabetic retinopathy

29 September 2017

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Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis

29 September 2017

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29 September 2017

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Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy

29 September 2017

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Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization

29 September 2017

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The PAR-aPKC system: lessons in polarity

29 September 2017

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Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor

29 September 2017

1 reference

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The potential role of octreotide in the treatment of diabetic retinopathy

29 September 2017

1 reference

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Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy

29 September 2017

1 reference

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Roles of PDGF in animal development

29 September 2017

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Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy

29 September 2017

1 reference

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Suppression of diabetic retinopathy with angiopoietin-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Tumor angiogenesis: therapeutic implications

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Vascular endothelial growth factor is a secreted angiogenic mitogen

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Wnt signaling mediates pathological vascular growth in proliferative retinopathy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Intravitreal injection of erythropoietin protects both retinal vascular and neuronal cells in early diabetes

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

A central role for inflammation in the pathogenesis of diabetic retinopathy

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

VEGF-initiated blood-retinal barrier breakdown in early diabetes.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661651

Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy

4 December 2018

1 reference

12 December 2020

Increased prostaglandin E2 (PGE2) levels in proliferative diabetic retinopathy, and correlation with VEGF and inflammatory cytokines

1 reference

12 December 2020

Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials--TAP report. Treatment of age-related macular degeneration with photodynamic therap

1 reference

12 December 2020

Increased levels of platelet-derived growth factor in vitreous fluid of patients with proliferative diabetic retinopathy

1 reference

12 December 2020

Vascular permeability factor, an endothelial cell mitogen related to PDGF

1 reference

12 December 2020

Early photocoagulation for diabetic retinopathy. ETDRS report number 9. Early Treatment Diabetic Retinopathy Study Research Group

1 reference

12 December 2020

Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor

1 reference

12 December 2020

VEGF is required for growth and survival in neonatal mice

1 reference

12 December 2020

Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes--the EURODIAB Prospective Complications Study

1 reference

12 December 2020

Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy

1 reference

12 December 2020

Angiographic and optical coherence tomographic results of the MARINA study of ranibizumab in neovascular age-related macular degeneration

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB12-1744

1 reference

16 August 2017

1 reference

16 August 2017

1 reference

PMCID

3661651