Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia (Q36875755)

16 August 2017

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title

Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia (English)

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16 August 2017

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3

Wolfgang Holzgreve

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16 August 2017

2

Sinuhe Hahn

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16 August 2017

Corinne Rusterholz

1

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16 August 2017

1 June 2007

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Seminars in Immunopathology

16 August 2017

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16 August 2017

29

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16 August 2017

2

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16 August 2017

151-162

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https://scigraph.springernature.com/pub.10.1007/s00281-007-0071-6

16 August 2017

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cites work

Protein expression and peptide binding suggest unique and interacting functional roles for HLA-E, F, and G in maternal-placental immune recognition

1 reference

https://api.crossref.org/works/10.1007%2FS00281-007-0071-6

Cytokine expression by first-trimester human chorionic villi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-007-0071-6

Transforming growth factor-beta 1 expression during placental development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-007-0071-6

Differential gene expression of TGF-beta isoforms and TGF-beta receptors during the first trimester of pregnancy at the human maternal-fetal interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-007-0071-6

Preeclampsia: an endothelial cell disorder

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00281-007-0071-6

Macrophage-induced apoptosis limits endovascular trophoblast invasion in the uterine wall of preeclamptic women

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-007-0071-6

Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-007-0071-6

In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-007-0071-6

Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-007-0071-6

Leukocyte adhesion molecules and reactive oxygen species in preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-007-0071-6

Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-007-0071-6

Anti-inflammatory effects of interleukin-4, interleukin-10, and transforming growth factor-beta on human placental cells in vitro

21 January 2018

1 reference

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Interleukin-10 messenger ribonucleic acid in human placenta: implications of a role for interleukin-10 in fetal allograft protection

21 January 2018

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12 December 2020

Tumor necrosis factor alpha mRNA and protein are present in human placental and uterine cells at early and late stages of gestation

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12 December 2020

The Distribution of Macrophages in Spiral Arteries of the Placental Bed in Pre-eclampsia Differs from that in Healthy Patients

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12 December 2020

Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation

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12 December 2020

Hypoxia: Implications for Implantation to Delivery—A Workshop Report

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12 December 2020

Human trophoblast function during the implantation process

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12 December 2020

Increased vascular endothelial cell production of interleukin-6 in severe preeclampsia

1 reference

12 December 2020

Expression of the placental cytokines tumor necrosis factor alpha, interleukin 1beta, and interleukin 10 is increased in preeclampsia.

1 reference

12 December 2020

Vitamins C and E and the risks of preeclampsia and perinatal complications

1 reference

12 December 2020

Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies.

1 reference

12 December 2020

Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy.

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12 December 2020

Trophoblastic remodeling in normal and preeclamptic pregnancies: implication of cytokines.

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12 December 2020

The placenta cytokine network and inflammatory signals

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12 December 2020

Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.

1 reference

12 December 2020

TH1/TH2 paradigm in pregnancy: paradigm lost? Cytokines in pregnancy/early abortion: reexamining the TH1/TH2 paradigm

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12 December 2020

Immunoreactive tumor necrosis factor-alpha is elevated in maternal plasma but undetected in amniotic fluid in the second trimester

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12 December 2020

Monocytes adhering by LFA-1 to placental syncytiotrophoblasts induce local apoptosis via release of TNF-alpha. A model for hematogenous initiation of placental inflammations.

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12 December 2020

Screening for cytokine mRNA in human villous and extravillous trophoblasts using the reverse-transcriptase polymerase chain reaction (RT-PCR)

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12 December 2020

Increased placental apoptosis in pregnancies complicated by preeclampsia

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12 December 2020

Preeclampsia is Associated with a Reduced Interleukin‐10 Production from Peripheral Blood Mononuclear Cells

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12 December 2020

Cytokine expression in peripheral blood lymphocytes indicates a switch to T(HELPER) cells in patients with preeclampsia

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12 December 2020

Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor

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12 December 2020

Placental oxidative stress: from miscarriage to preeclampsia

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12 December 2020

Interleukin-12 secretion by peripheral blood mononuclear cells is decreased in normal pregnant subjects and increased in preeclamptic patients

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12 December 2020

Interleukin-1, interleukin-6 and tumor necrosis factor at delivery in preeclamptic disorders

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12 December 2020

Decidual NK cells regulate key developmental processes at the human fetal-maternal interface.

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12 December 2020

Pre-eclampsia: more than pregnancy-induced hypertension

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12 December 2020

Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies

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12 December 2020

Macrophages in the basal plate of pre-eclamptic placentae

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12 December 2020

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

1 reference

12 December 2020

Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial.

1 reference

12 December 2020

The involvement of HLA-E and -F in pregnancy

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12 December 2020

Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia

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12 December 2020

Severely reduced presence of tissue macrophages in the basal plate of pre-eclamptic placentae

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12 December 2020

Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures

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12 December 2020

Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success

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12 December 2020

Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia

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12 December 2020

Immunohistochemical localization of IL-1 alpha and IL-1 beta in normal human placenta

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12 December 2020

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

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12 December 2020

Pre-eclampsia, the placenta and the maternal systemic inflammatory response--a review

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12 December 2020

Supernatants from co-cultured endothelial cells and syncytiotrophoblast microvillous membranes activate peripheral blood leukocytes in vitro

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12 December 2020

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)

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12 December 2020

Inhibition of trophoblast cell invasion by TGFB1, 2, and 3 is associated with a decrease in active proteases

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12 December 2020

Altered subcellular distribution of cadherin-5 in endothelial cells caused by the serum of pre-eclamptic patients

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12 December 2020

Genetic aspects of preeclampsia

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12 December 2020

Cytotoxicity of tumour necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts.

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12 December 2020

Molecular evidence of placental hypoxia in preeclampsia.

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12 December 2020

Placental superoxide is increased in pre-eclampsia

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12 December 2020

Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia

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12 December 2020

HLA-G and immune tolerance in pregnancy

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12 December 2020

A deficiency of placental IL-10 in preeclampsia.

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12 December 2020

HLA-G, pre-eclampsia, immunity and vascular events

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12 December 2020

IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes

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12 December 2020

Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae.

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12 December 2020

Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?

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12 December 2020

Aberrant uterine natural killer (NK)-cell expression and altered placental and serum levels of the NK-cell promoting cytokine interleukin-12 in pre-eclampsia

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12 December 2020

Cytokine secretion by decidual lymphocytes in transient hypertension of pregnancy and pre-eclampsia

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12 December 2020

Hypoxia stimulates cytokine production by villous explants from the human placenta

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12 December 2020

An innate view of human pregnancy

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12 December 2020

Expression of inflammatory cytokines in placentas from women with preeclampsia

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12 December 2020

Indications of an altered immune balance in preeclampsia: a decrease in in vitro secretion of IL-5 and IL-10 from blood mononuclear cells and in blood basophil counts compared with normal pregnancy.

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12 December 2020

Tumor necrosis factor-alpha is elevated in plasma and amniotic fluid of patients with severe preeclampsia

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12 December 2020

The role of soluble adhesion molecules in evaluating endothelial cell activation in preeclampsia

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12 December 2020

Placental expression of interferon-gamma (IFN-gamma) and its receptor IFN-gamma R2 fail to switch from early hypoxic to late normotensive development in preeclampsia.

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12 December 2020

Increased T-helper-1-type immunity and decreased T-helper-2-type immunity in patients with preeclampsia

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12 December 2020

Plasma factors in severe early-onset preeclampsia do not substantially alter endothelial gene expression in vitro.

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12 December 2020

Regulatory T cells in pregnancy

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12 December 2020

Inflammation and pre-eclampsia

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12 December 2020

Production of vasoactive substances by human umbilical vein endothelial cells after incubation with serum from preeclamptic patients.

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12 December 2020

Effects of interleukin-6 (IL-6) on cytotrophoblastic cells.

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12 December 2020

Latest advances in understanding preeclampsia

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12 December 2020

Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis.

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12 December 2020

Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia

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12 December 2020

Effects of serum from preeclamptic women on prostacyclin production by human endothelial cells

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12 December 2020

Oxidative stress reproduces placental abnormalities of preeclampsia

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12 December 2020

CD4(+) regulatory T cells

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12 December 2020

Increased superoxide generation is associated with decreased superoxide dismutase activity and mRNA expression in placental trophoblast cells in pre-eclampsia

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12 December 2020

Preeclampsia is associated with decreased placental interleukin-6 production

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12 December 2020

TNF downmodulates the function of human CD4+CD25hi T-regulatory cells

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12 December 2020

Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction?

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12 December 2020

HLA-G protein concentrations in maternal serum and placental tissue are decreased in preeclampsia

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12 December 2020

Tumour necrosis factor-alpha impairs chorionic gonadotrophin beta-subunit expression and cell fusion of human villous cytotrophoblast

1 reference

12 December 2020

Human decidual NK cells: unique phenotype and functional properties -- a review

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12 December 2020

Circulating levels of immunoreactive cytokines in women with preeclampsia

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12 December 2020

Class 1 major histocompatibility complex antigens on human extra-villous trophoblast

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12 December 2020

Hypoxia promotes interleukin-6 and -8 but reduces interleukin-10 production by placental trophoblast cells from preeclamptic pregnancies

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12 December 2020

Immunoregulation in normal pregnancy and pre-eclampsia: an overview

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12 December 2020

Localization of IL-4 and IL-4 receptors in the human term placenta, decidua and amniochorionic membranes

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12 December 2020

Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies

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12 December 2020

Subclassification of preeclampsia

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12 December 2020

First trimester human trophoblast expresses both interferon-gamma and interferon-gamma-receptor

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12 December 2020

Maternal uterine vascular lesions in the hypertensive complications of pregnancy

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12 December 2020

Increased endothelial monocyte chemoattractant protein-1 and interleukin-8 in preeclampsia

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12 December 2020

Cytokine production in first trimester chorionic villi: detection of mRNAs and protein products in situ

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12 December 2020

Activation of leukocytes during the uteroplacental passage in preeclampsia

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12 December 2020

Effect of hypoxia, oxidative stress and lipopolysaccharides on the release of prostaglandins and cytokines from human term placental explants

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12 December 2020

Expression pattern of cytokines in the different compartments of the feto-maternal unit under various conditions

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12 December 2020

NK cells and trophoblasts: partners in pregnancy

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12 December 2020

Lymphocyte subset distribution and cytokine secretion in third trimester decidua in normal pregnancy and preeclampsia

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12 December 2020

Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions

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12 December 2020

Immunological Tolerance

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12 December 2020

TNF alpha concentrations and mRNA expression are increased in preeclamptic placentas

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12 December 2020

Oxygen and trophoblast behaviour--a workshop report

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12 December 2020

Human uterine natural killer cells: a reappraisal

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12 December 2020

Cytokine mapping of sera from women with preeclampsia and normal pregnancies

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12 December 2020

Differential distribution of interleukin-1 alpha and interleukin-1 beta proteins in human placentas

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12 December 2020

T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion

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12 December 2020

Increased levels of cytokines and cytokine activity modifiers in normal pregnancy

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12 December 2020

Localization of transforming growth factor-beta at the human fetal-maternal interface: role in trophoblast growth and differentiation

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12 December 2020

Interleukin-18 in the plasma of women with preeclampsia

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12 December 2020

Altered protease expression by periarterial trophoblast cells in severe early-onset preeclampsia with IUGR

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12 December 2020

Pre-eclampsia is not associated with changes in the levels of regulatory T cells in peripheral blood

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12 December 2020

Phenotypic characterization of regulatory T cells in the human decidua.

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12 December 2020

Cytokine production by CD16-CD56bright natural killer cells in the human early pregnancy decidua

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12 December 2020

Preeclamptic women are deficient of interleukin-10 as assessed by cytokine release of trophoblast cells in vitro

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12 December 2020

Effects of tumour necrosis factor-alpha, interleukin-1 alpha, macrophage colony stimulating factor and transforming growth factor beta on trophoblastic matrix metalloproteinases

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12 December 2020

Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia.

1 reference

12 December 2020

Membrane-bound HLA-G activates proliferation and interferon-gamma production by uterine natural killer cells

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12 December 2020

Phenotypic and metabolic characteristics of monocytes and granulocytes in normal pregnancy and maternal infection

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12 December 2020

Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation

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12 December 2020

Fetal cells and cell-free fetal DNA in maternal blood: new insights into pre-eclampsia

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12 December 2020

Soluble factors released by placental villous tissue: Interleukin-1 is a potential mediator of endothelial dysfunction.

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12 December 2020

TNF-alpha is a predictor of insulin resistance in human pregnancy

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12 December 2020

Spontaneous and induced release of prostaglandins, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha by placental tissue from normal and preeclamptic pregnancies

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12 December 2020

Flow cytometric measurement of intracellular Th1 and Th2 cytokine production by human villous and extravillous cytotrophoblast

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12 December 2020

Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia

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12 December 2020

Expression profiles of interleukin-15 in early and late gestational human placenta and in pre-eclamptic placenta

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12 December 2020

Placental debris, oxidative stress and pre-eclampsia

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12 December 2020

Th1-type immunity is incompatible with successful pregnancy

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12 December 2020

IL-10 is an autocrine inhibitor of human placental cytotrophoblast MMP-9 production and invasion

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12 December 2020

Production of interleukin-6 by normal human trophoblast

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12 December 2020

A class I antigen, HLA-G, expressed in human trophoblasts

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12 December 2020

Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction

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12 December 2020

Circulating angiogenic factors in preeclampsia

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12 December 2020

T helper 1- and T helper 2-type cytokine imbalance in pregnant women with pre-eclampsia.

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12 December 2020

The influence of oxygen and tumor necrosis factor-alpha on the cellular kinetics of term placental villous explants in culture.

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12 December 2020

Disturbances in placental immunology: ready for therapeutic interventions?

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12 December 2020

Monocytes of preeclamptic women spontaneously synthesize pro-inflammatory cytokines.

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12 December 2020

Interleukin-1 beta regulates human cytotrophoblast metalloproteinase activity and invasion in vitro

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12 December 2020

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12 December 2020

Trophoblast-derived interleukin-6 (IL-6) regulates human chorionic gonadotropin release through IL-6 receptor on human trophoblasts

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12 December 2020

Activated macrophages inhibit human cytotrophoblast invasiveness in vitro

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12 December 2020

The in-vitro characterization of induced apoptosis in placental cytotrophoblasts and syncytiotrophoblasts

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12 December 2020

Gestational age-dependent expression of IL-10 and its receptor in human placental tissues and isolated cytotrophoblasts

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12 December 2020

Aberrant positioning of trophoblast and lymphocytes in the feto-maternal interface with pre-eclampsia.

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12 December 2020

Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family

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12 December 2020

Oxygen regulates human cytotrophoblast differentiation and invasion: implications for endovascular invasion in normal pregnancy and in pre-eclampsia

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12 December 2020

Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells

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12 December 2020

Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia

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12 December 2020

Cytokine regulation of endothelial cell function: from molecular level to the bedside

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12 December 2020

Soluble tumor necrosis factor receptors and interleukin-6 levels in patients with severe preeclampsia

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12 December 2020

10.1007/S00281-007-0071-6

Identifiers

DOI

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16 August 2017

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PubMed ID

17621700