Hedgehog signaling in mammary gland development and breast cancer (Q36876335)

16 August 2017

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title

Hedgehog signaling in mammary gland development and breast cancer (English)

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16 August 2017

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Sarah Hatsell

1

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PubMed ID

17623270

16 August 2017

Andra R Frost

series ordinal

2

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16 August 2017

1 September 2007

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Journal of Mammary Gland Biology and Neoplasia

16 August 2017

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16 August 2017

12

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16 August 2017

2-3

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16 August 2017

163-173

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https://scigraph.springernature.com/pub.10.1007/s10911-007-9048-2

16 August 2017

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cites work

Altered neural cell fates and medulloblastoma in mouse patched mutants

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12 December 2020

Essential role for Sonic hedgehog during hair follicle morphogenesis

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12 December 2020

Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts

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12 December 2020

Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1

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12 December 2020

Vertebrate Smoothened functions at the primary cilium

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12 December 2020

Differential requirements for shh in mammary tissue and hair follicle morphogenesis

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12 December 2020

Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes

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12 December 2020

Identification of pancreatic cancer stem cells

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12 December 2020

Emerging roles for hedgehog-patched-Gli signal transduction in reproduction

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12 December 2020

Molecular requirements for epithelial-mesenchymal transition during tumor progression

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12 December 2020

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

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12 December 2020

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

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12 December 2020

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

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12 December 2020

Identification of the mammary line in mouse by Wnt10b expression.

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12 December 2020

Ultrastructural studies of the female breast: I. 9 + 0 cilia in myoepithelial cells

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12 December 2020

Cilia and Hedgehog responsiveness in the mouse

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12 December 2020

Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

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12 December 2020

Basal cell nevus syndrome

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12 December 2020

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

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12 December 2020

The Gli2 transcription factor is required for normal mouse mammary gland development

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12 December 2020

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

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12 December 2020

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

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12 December 2020

Gli1 acts through Snail and E-cadherin to promote nuclear signaling by beta-catenin

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12 December 2020

The hedgehog signaling network, mammary stem cells, and breast cancer: connections and controversies

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12 December 2020

p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling

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12 December 2020

Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.

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12 December 2020

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

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12 December 2020

Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms

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12 December 2020

Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis

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12 December 2020

Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis

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12 December 2020

Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

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12 December 2020

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

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12 December 2020

Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas

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12 December 2020

All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

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12 December 2020

High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization

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12 December 2020

Gli3-mediated repression of Hedgehog targets is required for normal mammary development

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12 December 2020

Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer

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12 December 2020

No evidence for the H133Y mutation in SONIC HEDGEHOG in a collection of common tumour types

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12 December 2020

The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations

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12 December 2020

The consensus coding sequences of human breast and colorectal cancers

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12 December 2020

Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions

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12 December 2020

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

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12 December 2020

Medulloblastoma growth inhibition by hedgehog pathway blockade

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12 December 2020

Mammary stem cells, self-renewal pathways, and carcinogenesis

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12 December 2020

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

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12 December 2020

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

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12 December 2020

Interpreting epithelial cancer biology in the context of stem cells: tumor properties and therapeutic implications.

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12 December 2020

Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis

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12 December 2020

Nearly all cells in vertebrates and many cells in invertebrates contain primary cilia

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12 December 2020

Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis

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12 December 2020

Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2

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12 December 2020

The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells

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12 December 2020

The hedgehog signaling network

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12 December 2020

Hedgehog signaling is activated in subsets of esophageal cancers

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12 December 2020

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling

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12 December 2020

Activation of the hedgehog pathway in advanced prostate cancer

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12 December 2020

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

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12 December 2020

Activation of the hedgehog pathway in human hepatocellular carcinomas.

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12 December 2020

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

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12 December 2020

A mouse prostate cancer model induced by Hedgehog overexpression

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12 December 2020

An incredible decade for the primary cilium: a look at a once-forgotten organelle

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12 December 2020

A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway

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12 December 2020

Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development

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12 December 2020

Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors

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12 December 2020

The patched polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk.

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12 December 2020

The world according to hedgehog

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12 December 2020

Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

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12 December 2020

Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer

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12 December 2020

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

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12 December 2020

The primary cilium in cell signaling and cancer

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12 December 2020

Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation

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12 December 2020

Hedgehog signalling: how to get from Smo to Ci and Gli.

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12 December 2020

Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response.

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12 December 2020

Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer

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12 December 2020

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

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12 December 2020

Sonic hedgehog signaling is essential for hair development

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12 December 2020

Shh expression is required for embryonic hair follicle but not mammary gland development

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12 December 2020

Evidence for lack of enhanced hedgehog target gene expression in common extracutaneous tumors.

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12 December 2020

Basal cell carcinomas in mice overexpressing sonic hedgehog

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12 December 2020

Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells

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12 December 2020

Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia

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12 December 2020

Hedgehog signaling promotes prostate xenograft tumor growth

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12 December 2020

Hedgehog signaling in mouse mammary gland development and neoplasia

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12 December 2020

Histologic and ultrastructural features of adenoid cystic carcinoma of the breast

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12 December 2020

Activation of the hedgehog pathway in a subset of lung cancers

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12 December 2020

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

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12 December 2020

Medulloblastoma: a problem of developmental biology

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12 December 2020

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

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12 December 2020

Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling

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12 December 2020

Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

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12 December 2020

Hedgehog signaling in human hepatocellular carcinoma

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12 December 2020

Mutations in SUFU predispose to medulloblastoma

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12 December 2020

10.1007/S10911-007-9048-2

Identifiers

DOI

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16 August 2017

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PubMed ID

17623270