Hypoxia as a therapy for mitochondrial disease. (Q36882394)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26917594%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

Hypoxia as a therapy for mitochondrial disease (English)

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9 March 2020

0 references

1

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9 March 2020

Wolfram Goessling

12

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9 March 2020

14

Vamsi K Mootha

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9 March 2020

author name string

Luca Zazzeron

2

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9 March 2020

Rahul Goli

3

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9 March 2020

Kristen Alexa

4

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9 March 2020

Stephanie Schatzman-Bone

5

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9 March 2020

Harveen Dhillon

6

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9 March 2020

Olga Goldberger

7

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9 March 2020

Jun Peng

8

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9 March 2020

Ophir Shalem

9

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9 March 2020

Neville E Sanjana

10

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9 March 2020

Feng Zhang

11

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9 March 2020

Warren M Zapol

13

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9 March 2020

language of work or name

English

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publication date

25 February 2016

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9 March 2020

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9 March 2020

volume

352

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9 March 2020

page(s)

54-61

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9 March 2020

issue

6281

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A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome

9 March 2020

cites work

1 reference

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MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

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Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease

29 September 2017

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Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society

29 September 2017

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The multifaceted von Hippel-Lindau tumour suppressor protein

29 September 2017

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mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome

29 September 2017

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Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses

29 September 2017

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How mitochondrial dysfunction affects zebrafish development and cardiovascular function: an in vivo model for testing mitochondria-targeted drugs.

29 September 2017

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Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases

29 September 2017

1 reference

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Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo

29 September 2017

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Mitochondrial disorders as windows into an ancient organelle

29 September 2017

1 reference

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Treatment for mitochondrial disorders

29 September 2017

1 reference

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Monogenic mitochondrial disorders

29 September 2017

1 reference

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Mitochondria: in sickness and in health

29 September 2017

1 reference

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Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

Bioenergetic profiling of zebrafish embryonic development

29 September 2017

1 reference

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Hypoxia-inducible factors and the response to hypoxic stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.

29 September 2017

1 reference

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Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome

29 September 2017

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Highly parallel identification of essential genes in cancer cells

29 September 2017

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A mitochondrial protein compendium elucidates complex I disease biology

29 September 2017

1 reference

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Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy

29 September 2017

1 reference

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Mitochondrial disease: a practical approach for primary care physicians.

29 September 2017

1 reference

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

29 September 2017

1 reference

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

29 September 2017

1 reference

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

29 September 2017

1 reference

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Mitochondria, oxidants, and aging

29 September 2017

1 reference

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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

29 September 2017

1 reference

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

29 September 2017

1 reference

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

Growth and development in high altitude populations: a review of Ethiopian, Peruvian, and Nepalese studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

A zebrafish model to study and therapeutically manipulate hypoxia signaling in tumorigenesis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

Coming up for air: HIF-1 and mitochondrial oxygen consumption.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

Chemiosmotic coupling: The cost of living

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

Role of preoperative and postoperative sensorimotor training on restoration of the equilibrium behavior in adult mice following cerebellectomy.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860742

4 September 2018

Identifiers

DOI

10.1126/SCIENCE.AAD9642

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26917594%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26917594%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference