Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance (Q36885659)

16 August 2017

Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance (English)

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16 August 2017

1

Ulrich M Zanger

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16 August 2017

Kathrin Klein

2

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16 August 2017

Tanja Saussele

3

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16 August 2017

Julia Blievernicht

4

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16 August 2017

Marco H Hofmann

5

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16 August 2017

Matthias Schwab

6

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16 August 2017

1 July 2007

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16 August 2017

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16 August 2017

8

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16 August 2017

7

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16 August 2017

743-759

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57 varieties: the human cytochromes P450.

16 August 2017

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https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Pharmacogenetics and adverse drug reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Pharmacogenetics of the cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Pharmacogenomics and individualized drug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

The role of CYP2B6 in human xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Molecular mechanisms of genetic polymorphisms of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Pharmacogenetics of HIV therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: effect of induction by rifampin and ethnicity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Inhibition of human CYP2B6 by N,N',N''-triethylenethiophosphoramide is irreversible and mechanism-based

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Gene expression in distinct regions of the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Analysis of Human Cytochrome P450 Catalytic Activities and Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

A natural CYP2B6 TATA box polymorphism (-82T--> C) leading to enhanced transcription and relocation of the transcriptional start site.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Functional characterization of cytochrome P450 2B6 allelic variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Haplotype structure and allele frequencies of CYP2B6 in a Korean population.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Prevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New Guinea

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Highly variable mRNA expression and splicing of L-type voltage-dependent calcium channel alpha subunit 1C in human heart tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Predictive value of known and novel alleles of CYP2B6 for efavirenz plasma concentrations in HIV-infected individuals.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Baculovirus vectors: novel mammalian cell gene-delivery vehicles and their applications

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Identification of CYP2B6 sequence variants by use of multiplex PCR with allele-specific genotyping

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Three novel single nucleotide polymorphisms (SNPs) of the CYP2B6 gene in Japanese individuals.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Genetic, ethnic, and gender differences in the pharmacokinetics of antiretroviral agents

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Cytochrome P450 2B6 (CYP2B6) G516T influences nevirapine plasma concentrations in HIV-infected patients in Uganda

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

MALDI-TOF mass spectrometry for multiplex genotyping of CYP2B6 single-nucleotide polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Bupropion: pharmacology and therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

CYP2B6 genotype does not alter nicotine metabolism, plasma levels, or abstinence with nicotine replacement therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Pharmacogenetic investigation of smoking cessation treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Drugs and genotypes: how pharmacogenetic information could improve smoking cessation treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Pharmacogenetics of cyclophosphamide in patients with hematological malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Intra- and inter-ethnic differences in the allele frequencies of cytochrome P450 2B6 gene in Chinese.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz: the effect of gender, race, and CYP2B6 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Stereoselective Block of hERG Channel by (S)-Methadone and QT Interval Prolongation in CYP2B6 Slow Metabolizers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.743

21 January 2018

Identifiers

DOI

10.2217/14622416.8.7.743

1 reference

16 August 2017

1 reference