Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic beta cell (Q36908504)

17 August 2017

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title

Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic beta cell (English)

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17 August 2017

P A Halban

1

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PubMed ID

1769434

17 August 2017

language of work or name

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1 November 1991

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17 August 2017

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17 August 2017

34

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17 August 2017

11

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17 August 2017

767-778

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https://scigraph.springernature.com/pub.10.1007/bf00408349

17 August 2017

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https://api.crossref.org/works/10.1007%2FBF00408349

Mechanism of protein translocation across the endoplasmic reticulum membrane

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https://api.crossref.org/works/10.1007%2FBF00408349

The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00408349

Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00408349

Proinsulin modified by analogues of arginine and lysine is degraded rapidly in pancreatic B-cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00408349

The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide

21 January 2018

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12 December 2020

Heat shock and the sorting of luminal ER proteins.

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12 December 2020

The insulin factory: a tour of the plant surroundings and a visit to the assembly line. The Minkowski lecture 1973 revisited

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12 December 2020

The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation

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12 December 2020

Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin

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12 December 2020

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

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12 December 2020

Mutations in signal sequence cleavage domain of preproparathyroid hormone alter protein translocation, signal sequence cleavage, and membrane-binding properties

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12 December 2020

Unity in function in the absence of consensus in sequence: role of leader peptides in export

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Role of microtubules in the synthesis, conversion, and release of (pro)insulin. A biochemical and radioautographic study in rat islets

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12 December 2020

Protein disulfide isomerase: multiple roles in the modification of nascent secretory proteins

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12 December 2020

Regulation of insulin-gene expression. Implications for gene therapy

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Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein

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12 December 2020

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway

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12 December 2020

Insulin, not C-peptide (proinsulin), is present in crinophagic bodies of the pancreatic B-cell

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12 December 2020

Direct measurement of plasma proinsulin in normal and diabetic subjects

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12 December 2020

Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells

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12 December 2020

Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles

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12 December 2020

Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump

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12 December 2020

Lessons learned from molecular biology of insulin-gene mutations

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Recognition of nascent polypeptides for targeting and folding

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Signal sequences. The limits of variation

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The tissue-specific processing of Pro-ACTH/Endorphin recent advances and unsolved problems

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Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model

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Efficient targeting to storage granules of human proinsulins with altered propeptide domain

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12 December 2020

The trans Golgi network: sorting at the exit site of the Golgi complex.

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Influence of Glucose on Insulin Handling by Rat Islets in Culture: A Reflection of Integrated Changes in Insulin Biosynthesis, Release, and Intracellular Degradation

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12 December 2020

A superactive insulin: [B10-aspartic acid]insulin(human).

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Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases

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The trans-most cisternae of the Golgi complex: a compartment for sorting of secretory and plasma membrane proteins

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A circulating variant of human proalbumin

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NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition

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Molecular dissection of early stages of the eukaryotic secretory pathway

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SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast

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Role of zinc in insulin biosynthesis. Some possible zinc-insulin interactions in the pancreatic B-cell

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12 December 2020

Cell-free protein sorting to the regulated and constitutive secretory pathways

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12 December 2020

Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors

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12 December 2020

Circulating proinsulin in patients with maturity onset diabetes

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12 December 2020

Precursors for peptide hormones share common secondary structures forming features at the proteolytic processing sites

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12 December 2020

Purification of three related peripheral membrane proteins needed for vesicular transport

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12 December 2020

An in vivo characterization of the cleavage site specificity of the insulin cell prohormone processing enzymes.

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12 December 2020

Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation

1 reference

12 December 2020

Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells

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12 December 2020

Relative Hypersecretion of Proinsulin in Rat Model of NIDDM

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12 December 2020

Biosynthetic protein transport and sorting by the endoplasmic reticulum and Golgi

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12 December 2020

Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway

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12 December 2020

Banting lecture 1990. Beta-cells in type II diabetes mellitus

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12 December 2020

Resistance of the insulin crystal to lysosomal proteases: implications for pancreatic B-cell crinophagy.

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12 December 2020

The rate of bulk flow from the Golgi to the plasma membrane

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12 December 2020

Differential kinetics of rat insulin I and II processing in rat islets of Langerhans

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12 December 2020

Degradation from the endoplasmic reticulum: disposing of newly synthesized proteins

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12 December 2020

Pathways of protein secretion in eukaryotes.

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12 December 2020

Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers

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12 December 2020

Calcium-dependent KEX2-like protease found in hepatic secretory vesicles converts proalbumin to albumin.

1 reference

12 December 2020

Contrasting patterns of insulin biosynthesis, compartmental storage, and secretion. Rat tumor versus islet cells

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12 December 2020

A motif found in propeptides and prohormones that may target them to secretory vesicles

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12 December 2020

Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing

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12 December 2020

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

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12 December 2020

Studies on the molecular organization of rat insulin secretory granules.

1 reference

12 December 2020

Vesicular transport between the endoplasmic reticulum and the Golgi stack requires the NEM-sensitive fusion protein.

1 reference

12 December 2020

The relationships of concentrations of insulin, intact proinsulin and 32-33 split proinsulin with cardiovascular risk factors in type 2 (non-insulin-dependent) diabetic subjects.

1 reference

12 December 2020

Predominance of clathrin light chain LCb correlates with the presence of a regulated secretory pathway

1 reference

12 December 2020

Protein transport across the ER membrane

1 reference

12 December 2020

Proinsulin trafckin and processing in the pancreatic B cell

1 reference

12 December 2020

Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells

1 reference

12 December 2020

Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance

1 reference

12 December 2020

Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content

1 reference

12 December 2020

A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein beta-adaptin.

1 reference

12 December 2020

Inhibition of proinsulin to insulin conversion in rat islets using arginine and lysine analogs. Lack of effect on rate of release of modified products

1 reference

12 December 2020

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans

1 reference

12 December 2020

Condensation-sorting events in the rough endoplasmic reticulum of exocrine pancreatic cells

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12 December 2020

Monomeric insulins obtained by protein engineering and their medical implications

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12 December 2020

Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin.

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12 December 2020

Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet beta-cell dysfunction?

1 reference

12 December 2020

Glucose regulation of insulin gene expression

1 reference

12 December 2020

Heterogeneity of expression and secretion of native and mutant [AspB10]insulin in AtT20 cells

1 reference

12 December 2020

Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus

1 reference

12 December 2020

Nonconverted, amino acid analog-modified proinsulin stays in a Golgi-derived clathrin-coated membrane compartment

1 reference

12 December 2020

Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules

1 reference

12 December 2020

Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells

1 reference

12 December 2020

Role of ATP in the Intracellular Translocation of Proinsulin and Insulin in the Rat Pancreatic B Cell

1 reference

12 December 2020

The insulin secretory granule

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12 December 2020

Intracellular Aspects of the Process of Protein Synthesis

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12 December 2020

Molecular sorting in the secretory pathway

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12 December 2020

(Pro)insulin associates with Golgi membranes of pancreatic B cells

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00408349

1 reference

17 August 2017

1 reference

PubMed ID

1769434