Alterations in drug disposition during pregnancy: implications for drug therapy (Q36909328)

17 August 2017

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title

Alterations in drug disposition during pregnancy: implications for drug therapy (English)

1 reference

17 August 2017

Lucy S Hodge

1

1 reference

PubMed ID

17696806

17 August 2017

Timothy S Tracy

series ordinal

2

1 reference

PubMed ID

17696806

17 August 2017

language of work or name

English

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publication date

1 August 2007

1 reference

Expert Opinion on Drug Metabolism & Toxicology

17 August 2017

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17 August 2017

3

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17 August 2017

4

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17 August 2017

557-571

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Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

The impact of pregnancy and childbirth on the metabolism of lamotrigine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Assessment of the hepatic arterial and portal venous blood flows during pregnancy with Doppler ultrasonography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Maternal kinetics of morphine during labour

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Changes in urinary excretion of six biochemical parameters in normotensive pregnancy and preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Serum protein binding of drugs during and after pregnancy in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Renal function during normal pregnancy and preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Association of maternal caffeine consumption with decrements in fetal growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

CYP1A2 activity, gender and smoking, as variables influencing the toxicity of caffeine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Plasma caffeine metabolite ratio (17X/137X) in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Longitudinal effects of pregnancy on the pharmacokinetics of theophylline

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Olanzapine. Pharmacokinetic and pharmacodynamic profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Accelerated metabolism of nicotine and cotinine in pregnant smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Female sex and oral contraceptive use accelerate nicotine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Pharmacokinetics of anticonvulsants in pregnancy: alterations in plasma protein binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

The pharmacokinetics of nelfinavir and M8 during pregnancy and post partum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

The effect of ethinyloestradiol and levonorgestrel on the CYP2C19-mediated metabolism of omeprazole in healthy female subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Citalopram in pregnancy and lactation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Pharmacokinetics of fluoxetine and norfluoxetine in pregnancy and lactation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Changes to methadone clearance during pregnancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Pharmacokinetics of nelfinavir and indinavir in HIV-1-infected pregnant women

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Pharmacokinetic drug interactions involving 17alpha-ethinylestradiol: a new look at an old drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Inhibitory effect of medroxyprogesterone acetate on human liver cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1'-hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Individual changes in lamotrigine plasma concentrations during pregnancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Gestation-induced changes in lamotrigine pharmacokinetics: a monotherapy study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Kinetic disposition of lorazepam with focus on the glucuronidation capacity, transplacental transfer in parturients and racemization in biological samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Paracetamol metabolism in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Ethinyl estradiol, not progestogens, reduces lamotrigine serum concentrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Drug transfer and metabolism by the human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Immunochemical and molecular biological studies on human placental cigarette smoke-inducible cytochrome P-450-dependent monooxygenase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Cytochrome P450 CYP1A1 enzyme activity and DNA adducts in placenta of women environmentally exposed to organochlorines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

The adverse effects of maternal smoking on the human placenta: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Acetaldehyde production and transfer by the perfused human placental cotyledon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Human placental glucuronidation and transport of 3'azido-3'-deoxythymidine and uridine diphosphate glucuronic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Regiospecificity of placental metabolism by cytochromes P450 and glutathione S-transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Effects of gestational and overt diabetes on placental cytochromes P450 and glutathione S-transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Sulfation of drugs and hormones in mid-gestation human fetus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Sulphate conjugation of beta 2-adrenoceptor stimulating drugs by platelet and placental phenol sulphotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Human placenta: a human organ for developmental toxicology research and biomonitoring

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Active transport across the human placenta: impact on drug efficacy and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Biochemistry of multidrug resistance mediated by the multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

P-glycoprotein in the placenta: expression, localization, regulation and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Expression and function of ABCB1 and ABCG2 in human placental tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Stage-specific distribution of P-glycoprotein in first-trimester and full-term human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Variable expression of MRP2 (ABCC2) in human placenta: influence of gestational age and cellular differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Developmental expression of cytochrome P450 enzymes in human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Cytochrome P450 in human fetal liver: significance and fetal-specific expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Differential catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Developmental expression of human hepatic CYP2C9 and CYP2C19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Fetal morphine metabolism and clearance are constant during late gestation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Pharmacokinetics of glyburide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Pharmacokinetic drug interaction profiles of proton pump inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

The case for lamotrigine monitoring in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Physiological Alterations during Pregnancy: Impact on Toxicokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

Chronic propranolol administration during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.4.557

21 January 2018

Identifiers

DOI

10.1517/17425255.3.4.557

1 reference

17 August 2017

1 reference

PubMed ID

17696806