Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies (Q36910217)

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scientific article published on 30 April 2013

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English	Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies	scientific article published on 30 April 2013

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29 February 2020

Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies (English)

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29 February 2020

traumatic brain injury

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Bridget E. Hawkins

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Diana L Castillo-Carranza

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Donald S Prough

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Donald S Prough

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Shashirekha Krishnamurthy

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Urmi Sengupta

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George R Jackson

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Douglas S DeWitt

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Rakez Kayed

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30 April 2013

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29 February 2020

Journal of Biological Chemistry

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29 February 2020

17042-17050

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29 February 2020

Physiological release of endogenous tau is stimulated by neuronal activity.

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Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

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Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.

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Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

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A fluid percussion model of experimental brain injury in the rat

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12 December 2020

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29 February 2020

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29 February 2020

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29 February 2020

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