Chirality and pharmacokinetics: an area of neglected dimensionality? (Q36914170)

17 August 2017

1 reference

title

Chirality and pharmacokinetics: an area of neglected dimensionality? (English)

1 reference

17 August 2017

1 reference

Andrew J Hutt

1

1 reference

17 August 2017

publication date

1 January 2007

1 reference

Drug Metabolism and Drug Interactions

17 August 2017

published in

1 reference

17 August 2017

volume

22

1 reference

17 August 2017

issue

2-3

1 reference

17 August 2017

page(s)

79-112

1 reference

Stereoselectivity of bioactive xenobiotics. A pre-Pasteur attitude in medicinal chemistry, pharmacokinetics and clinical pharmacology

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Separation of enantiomers: needs, challenges, perspectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Effective use of preparative chiral HPLC in a preclinical drug synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Enantiopure drug synthesis: from methyldopa to imipenem to efavirenz

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Interpretation of experiments on metabolic processes, using isotopic tracer elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Prochiral selectivity and intramolecular isotope effects in the cytochrome P-450 catalyzed omega-hydroxylation of cumene

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Intramolecular deuterium isotope effect and enantiotopic differentiation in oxidative demethylation of chiral [monomethyl-d3]methoxychlor in rat liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Diastereoisomerism, contact points, and chiral selectivity: a four-site saga

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Stereoselectivity of the folate transporter in rabbit small intestine: studies with amethopterin enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Stereoselective disposition of talinolol in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Enantioselective tissue distribution of the basic drugs disopyramide, flecainide and verapamil in rats: role of plasma protein and tissue phosphatidylserine binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Stereoselective transport of baclofen across the blood-brain barrier in rats as determined by the unit impulse response methodology

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Stereoselective delivery and actions of beta receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Single- and multiple-dose pharmacokinetics of R-(-)-and S-(+)-prenylamine in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Stereoselectivity in pharmacokinetics: a general theory

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Effects of armodafinil in the treatment of residual excessive sleepiness associated with obstructive sleep apnea/hypopnea syndrome: a 12-week, multicenter, double-blind, randomized, placebo-controlled study in nCPAP-adherent adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Adjunct armodafinil improves wakefulness and memory in obstructive sleep apnea/hypopnea syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Stereospecific determination, chiral inversion in vitro and pharmacokinetics in humans of the enantiomers of thalidomide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Enantiomer specific pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Absolute configuration of the major metabolite of 5,5-diphenylhydantoin,5-(4'-hydroxyphenyl)-5-phenylhydantoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Enantiomeric disposition of inhaled, intravenous and oral racemic-salbutamol in man--no evidence of enantioselective lung metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Verapamil stereoisomerism: Enantiomeric ratios in plasma dependent on peak concentrations, oral input rate, or both*

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Influence of age on the enantiomeric disposition of ibuprofen in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Disposition of flurbiprofen in man: influence of stereochemistry and age

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Racial differences in propranolol pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

The stereoselective uptake of ibuprofen enantiomers into adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Enantioselective Analysis of Chloroquine and Desethylchloroquine after Oral Administration of Racemic Chloroquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

In vivo interaction of the enantiomers of disopyramide in human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Active Transport of L-Dopa in the Intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

Toxicity and Teratogenicity of Optical Isomers of Thalidomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2007.22.2-3.79

10.1515/DMDI.2007.22.2-3.79

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference