Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable (Q36916035)

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14 January 2020

title

Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable (English)

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paroxysmal extreme pain disorder

14 January 2020

main subject

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1 reference

2

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14 January 2020

author name string

Sulayman D Dib-Hajj

1

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14 January 2020

Brian W Jarecki

3

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14 January 2020

Lynda Tyrrell

4

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14 January 2020

Tanya Z Fischer

5

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14 January 2020

Mark Lawden

6

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14 January 2020

Theodore R Cummins

7

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14 January 2020

Stephen G Waxman

8

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14 January 2020

publication date

19 September 2008

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14 January 2020

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14 January 2020

volume

4

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14 January 2020

page(s)

37

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https://scigraph.springernature.com/pub.10.1186/1744-8069-4-37

14 January 2020

exact match

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cites work

Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation

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Differential block of sensory neuronal voltage-gated sodium channels by lacosamide [(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide], lidocaine, and carbamazepine

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Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade

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From genes to pain: Na v 1.7 and human pain disorders

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An SCN9A channelopathy causes congenital inability to experience pain

29 September 2017

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SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

29 September 2017

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Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating

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Inherited erythermalgia: limb pain from an S4 charge-neutral Na channelopathy

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Autosomal dominant erythermalgia associated with a novel mutation in the voltage-gated sodium channel alpha subunit Nav1.7.

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Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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27 June 2018

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27 June 2018

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27 June 2018

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27 June 2018

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Primary erythermalgia as a sodium channelopathy: screening for SCN9A mutations: exclusion of a causal role of SCN10A and SCN11A.

27 June 2018

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A novel founder SCN4A mutation causes painful cold-induced myotonia in French-Canadians.

4 September 2018

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4 September 2018

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Genetic heterogeneity and exclusion of a modifying locus at 2q in a family with autosomal dominant primary erythermalgia.

4 September 2018

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Solution structures of the cytoplasmic linkers between segments S4 and S5 (S4-S5) in domains III and IV of human brain sodium channels in SDS micelles

4 September 2018

1 reference

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Phenytoin and carbamazepine: differential inhibition of sodium currents in small cells from adult rat dorsal root ganglia.

4 September 2018

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4 September 2018

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Spinal sensory neurons express multiple sodium channel alpha-subunit mRNAs.

4 September 2018

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Sodium channels as molecular targets for antiepileptic drugs

4 September 2018

1 reference

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A large German kindred with cold-aggravated myotonia and a heterozygous A1481D mutation in the SCN4A gene

20 October 2018

1 reference

12 December 2020

Gating Properties of SCN5A Mutations and the Response to Mexiletine in Long-QT Syndrome Type 3 Patients

1 reference

12 December 2020

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12 December 2020

Sensory and electrophysiological properties of guinea-pig sensory neurones expressing Nav 1.7 (PN1) Na+ channel alpha subunit protein

1 reference

12 December 2020

Role in fast inactivation of conserved amino acids in the IV/S4-S5 loop of the human muscle Na+ channel

1 reference

12 December 2020

Identifiers

DOI

10.1186/1744-8069-4-37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18803825%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

14 January 2020

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14 January 2020

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