Vitamin D signalling pathways in cancer: potential for anticancer therapeutics (Q36919979)

17 August 2017

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title

Vitamin D signalling pathways in cancer: potential for anticancer therapeutics (English)

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17 August 2017

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Kristin K Deeb

1

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17 August 2017

Donald L Trump

series ordinal

2

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17 August 2017

Candace S Johnson

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 September 2007

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17 August 2017

Nature Reviews Cancer

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17 August 2017

7

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17 August 2017

684-700

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17 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrc2196

17 August 2017

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cites work

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Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction

31 March 2020

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Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning

31 March 2020

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Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia

31 March 2020

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Characterization of a vitamin D receptor knockout mouse as a model of colorectal hyperproliferation and DNA damage

31 March 2020

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Vitamin D receptor (VDR) ablation alters carcinogen-induced tumorigenesis in mammary gland, epidermis and lymphoid tissues

31 March 2020

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Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis

31 March 2020

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Vitamin D receptor status alters mammary gland morphology and tumorigenesis in MMTV-neu mice

31 March 2020

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Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D

31 March 2020

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Do sunlight and vitamin D reduce the likelihood of colon cancer?

31 March 2020

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Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study

31 March 2020

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Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D and Risk of Breast Cancer

31 March 2020

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Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland)

31 March 2020

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Prospective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality in Men

31 March 2020

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Vitamin D, calcium, and breast cancer risk: a review

31 March 2020

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Vitamin D and the epidemiology of prostate cancer

31 March 2020

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Vitamin D and prevention of colorectal cancer

31 March 2020

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Circulating 25-Hydroxyvitamin D Levels Predict Survival in Early-Stage Non–Small-Cell Lung Cancer Patients

31 March 2020

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Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D

31 March 2020

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The nuclear vitamin D receptor: biological and molecular regulatory properties revealed.

31 March 2020

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25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis

31 March 2020

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Regulation of 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxyvitamin D3.

31 March 2020

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1alpha-Hydroxylase and the action of vitamin D.

31 March 2020

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The promoter of the human 25-hydroxyvitamin D3 1 alpha-hydroxylase gene confers positive and negative responsiveness to PTH, calcitonin, and 1 alpha,25(OH)2D3.

31 March 2020

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Autocrine metabolism of vitamin D in normal and malignant breast tissue

31 March 2020

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25-Hydroxyvitamin D(3)-1alpha-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis

31 March 2020

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25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression

31 March 2020

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25-hydroxyvitamin D3-1alpha-hydroxylase expression in normal and malignant human colon.

31 March 2020

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Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer.

31 March 2020

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The Vitamin D endocrine system of the gut--its possible role in colorectal cancer prevention.

31 March 2020

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Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene

31 March 2020

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Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization

31 March 2020

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Expression of VDR and CYP24A1 mRNA in human tumors

31 March 2020

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Enhancement of antiproliferative activity of 1alpha,25-dihydroxyvitamin D3 (analogs) by cytochrome P450 enzyme inhibitors is compound- and cell-type specific

31 March 2020

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CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer

31 March 2020

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The steroid and thyroid hormone receptor superfamily

31 March 2020

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Multiple promoters direct the tissue-specific expression of novel N-terminal variant human vitamin D receptor gene transcripts

31 March 2020

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Two nuclear signalling pathways for vitamin D

31 March 2020

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Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.

31 March 2020

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The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators

31 March 2020

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The role of chromatin during transcription

31 March 2020

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Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells

31 March 2020

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Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells

31 March 2020

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Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3

31 March 2020

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Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching

31 March 2020

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Ligand-induced transrepression by VDR through association of WSTF with acetylated histones

31 March 2020

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1Alpha,25(OH)2D3-induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter

31 March 2020

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1alpha,25(OH)2D3-induced DNA methylation suppresses the human CYP27B1 gene

31 March 2020

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Epigenetic regulation of vitamin D hydroxylase expression and activity in normal and malignant human prostate cells

31 March 2020

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Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors

31 March 2020

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Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements

31 March 2020

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Sequence elements in the human osteocalcin gene confer basal activation and inducible response to hormonal vitamin D3.

31 March 2020

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Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

31 March 2020

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G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer

31 March 2020

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Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter

31 March 2020

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Differential modulation of fos and jun gene expression by 1,25-dihydroxyvitamin D3.

31 March 2020

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Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators

31 March 2020

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Nongenomic actions of steroid hormones

31 March 2020

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Minireview: vitamin D receptor: new assignments for an already busy receptor

31 March 2020

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The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitro

31 March 2020

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Ribozyme knockdown functionally links a 1,25(OH)2D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells.

31 March 2020

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Calcium transport in perfused duodena from normal chicks: enhancement within fourteen minutes of exposure to 1,25-dihydroxyvitamin D3

31 March 2020

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1,25(OH)2 vitamin D3 stimulates membrane phosphoinositide turnover, activates protein kinase C, and increases cytosolic calcium in rat colonic epithelium

31 March 2020

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The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium

31 March 2020

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The functional consequences of cross-talk between the vitamin D receptor and ERK signaling pathways are cell-specific

31 March 2020

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Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function

31 March 2020

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Vitamin D inhibits the formation of prostatic intraepithelial neoplasia in Nkx3.1;Pten mutant mice.

31 March 2020

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Vitamin D inhibition of prostate adenocarcinoma growth and metastasis in the Dunning rat prostate model system

31 March 2020

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Effects of synthetic vitamin D analogues on breast cancer cell proliferation in vivo and in vitro

31 March 2020

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1 alpha,25-Dihydroxyvitamin D(3) is a preventive factor in the metastasis of lung cancer

31 March 2020

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Activation of extracellular signal-regulated kinases (ERKs) defines the first phase of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells

31 March 2020

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Antiproliferative action of vitamin D.

31 March 2020

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1 alpha,25-dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo

31 March 2020

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1,25-Dihydroxyvitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells

31 March 2020

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Action of 1,25(OH)2D3 on the cell cycle genes, cyclin D1, p21 and p27 in MCF-7 cells

31 March 2020

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p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase

31 March 2020

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Down regulation of NM23.H1, NM23.H2 and c-myc genes during differentiation induced by 1,25 dihydroxyvitamin D3

31 March 2020

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1alpha,25-dihydroxyvitamin D(3)-induced myeloid cell differentiation is regulated by a vitamin D receptor-phosphatidylinositol 3-kinase signaling complex

31 March 2020

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1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation

31 March 2020

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Vitamin D3 modulated gene expression patterns in human primary normal and cancer prostate cells

31 March 2020

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1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation

31 March 2020

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1alpha,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells.

31 March 2020

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Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.

31 March 2020

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Vitamin D(3)-induced apoptosis of murine squamous cell carcinoma cells. Selective induction of caspase-dependent MEK cleavage and up-regulation of MEKK-1.

31 March 2020

1 reference

Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase

31 March 2020

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Differential antiproliferative effects of calcitriol on tumor-derived and matrigel-derived endothelial cells

31 March 2020

1 reference

Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries

31 March 2020

1 reference

Inhibition of angiogenesis as a mechanism for inhibition by 1alpha-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 of colon carcinogenesis induced by azoxymethane in Wistar rats.

31 March 2020

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1,25-Dihydroxyvitamin D3 stimulates vascular smooth muscle cell proliferation through a VEGF-mediated pathway.

31 March 2020

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1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis.

31 March 2020

1 reference

Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol.

31 March 2020

1 reference

The vitamin D3 analog, ILX-23-7553, enhances the response to adriamycin and irradiation in MCF-7 breast tumor cells

31 March 2020

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Combined effect of vitamin D3 analogs and paclitaxel on the growth of MCF-7 breast cancer cells in vivo

31 March 2020

1 reference

Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer

31 March 2020

1 reference

Combined differentiating therapy for myelodysplastic syndromes: a phase II study.

31 March 2020

1 reference

Treatment of acute myeloid leukemia in the elderly with low-dose cytarabine, hydroxyurea, and calcitriol

31 March 2020

1 reference

Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation

31 March 2020

1 reference

A limited sampling method for the estimation of serum calcitriol area under the curve in cancer patients

31 March 2020

1 reference

Pharmacokinetics of high-dose oral calcitriol: results from a phase 1 trial of calcitriol and paclitaxel

31 March 2020

1 reference

Phase II trial of oral 1,25-dihydroxyvitamin D (calcitriol) in hormone refractory prostate cancer

31 March 2020

1 reference

Pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 in normal mice after systemic exposure to effective and safe antitumor doses

31 March 2020

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Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3.

31 March 2020

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Responsiveness of human retinoblastoma and neuroblastoma models to a non-calcemic 19-nor Vitamin D analog.

31 March 2020

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Phase I study of weekly DN-101, a new formulation of calcitriol, in patients with cancer

31 March 2020

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Pharmacokinetics and tolerability of a single dose of DN-101, a new formulation of calcitriol, in patients with cancer

31 March 2020

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A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors.

31 March 2020

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High-dose calcitriol and carboplatin in metastatic androgen-independent prostate cancer

31 March 2020

1 reference

Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators

31 March 2020

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Phase II trial of high-dose, intermittent calcitriol (1,25 dihydroxyvitamin D3) and dexamethasone in androgen-independent prostate cancer.

31 March 2020

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Enhancement of 1,25-dihydroxyvitamin D3-mediated antitumor activity with dexamethasone

31 March 2020

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Weekly high-dose calcitriol and docetaxel in advanced prostate cancer

31 March 2020

1 reference

Selective estrogen receptor modulators (SERMs): mechanisms of anticarcinogenesis and drug resistance

31 March 2020

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Vitamin D receptor modulators for inflammation and cancer

31 March 2020

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Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.

31 March 2020

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Novel nonsecosteroidal vitamin D receptor modulator inhibits the growth of LNCaP xenograft tumors in athymic mice without increased serum calcium

31 March 2020

1 reference

A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma

31 March 2020

1 reference

A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer

31 March 2020

1 reference

A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer

31 March 2020

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Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy

31 March 2020

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Vitamin D2 analog 19-nor-1,25-dihydroxyvitamin D2: antitumor activity against leukemia, myeloma, and colon cancer cells

31 March 2020

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High dose calcitriol may reduce thrombosis in cancer patients

31 March 2020

1 reference

Identification of amino acid sequence in the hinge region of human vitamin D receptor that transfers a cytosolic protein to the nucleus

31 March 2020

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Nuclear import of the retinoid X receptor, the vitamin D receptor, and their mutual heterodimer

31 March 2020

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Polymorphisms in the MTHFR and VDR genes and skin cancer risk

31 March 2020

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Start codon polymorphisms in the vitamin D receptor and colorectal cancer risk

31 March 2020

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Haplotype analysis of common vitamin D receptor variants and colon and rectal cancers

31 March 2020

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Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor

31 March 2020

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Polymorphisms of vitamin D receptor gene protect against the risk of head and neck cancer

31 March 2020

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Expression of vitamin D receptor and 25-hydroxyvitamin D3-1{alpha}-hydroxylase in normal and malignant human colon

31 March 2020

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The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer.

31 March 2020

1 reference

Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1alpha,25-dihydroxyvitamin D3.

31 March 2020

1 reference

Analysis of the vitamin D system in basal cell carcinomas (BCCs).

31 March 2020

1 reference

Expression of 25-hydroxyvitamin D-1-alpha-hydroxylase mRNA in individuals with colorectal cancer

31 March 2020

1 reference

Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol

31 March 2020

1 reference

Towards a complete picture of splice variants of the gene for 25-hydroxyvitamin D31alpha-hydroxylase in brain and skin cancer

31 March 2020

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Analysis of the vitamin D system in cutaneous squamous cell carcinomas

31 March 2020

1 reference

Clinical significance of the overexpression of the candidate oncogene CYP24 in esophageal cancer

31 March 2020

1 reference

Treatment of myelodysplastic syndromes with retinoic acid and 1 alpha-hydroxy-vitamin D3 in combination with low-dose ara-C is not superior to ara-C alone. Results from a randomized study. The Scandinavian Myelodysplasia Group (SMG).

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRC2196

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Dimensions Publication ID

17 August 2017

1021224284

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Fatcat ID

release_3mr7wzpoozbppfzf5egv37kil4

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Fatcat

https://api.fatcat.wiki/v0/release/3mr7wzpoozbppfzf5egv37kil4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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