Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea. (Q36926307)

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scientific article published on July 2008

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English	Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea.	scientific article published on July 2008

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1 January 2020

Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea (English)

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Danielle Julie Carrier

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Bill J Gurley

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Ashley Swain

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Martha A Hubbard

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D Keith Williams

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Gary Barone

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Faith Hartsfield

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Yudong Tong

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Shreekar Cheboyina

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Sunil K Battu

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1 July 2008

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Molecular Nutrition and Food Research

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1 January 2020

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1 January 2020

755-763

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1 January 2020

Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping

1 reference

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29 September 2017

Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract

1 reference

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29 September 2017

The effect of St John's wort extracts on CYP3A: a systematic review of prospective clinical trials

1 reference

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29 September 2017

Herbal product-drug interactions mediated by induction

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29 September 2017

Evaluation of the botanical authenticity and phytochemical profile of black cohosh products by high-performance liquid chromatography with selected ion monitoring liquid chromatography-mass spectrometry

1 reference

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29 September 2017

Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin

1 reference

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29 September 2017

Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans

1 reference

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29 September 2017

Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Isolation of CYP3A4 Inhibitors from the Black Cohosh (Cimicifuga racemosa)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Herb-drug interactions: a literature review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Herbal interactions involving cytochrome p450 enzymes: a mini review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Increasing trends in elderly persons' use of nonvitamin, nonmineral dietary supplements and concurrent use of medications

1 reference

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29 September 2017

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

1 reference

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29 September 2017

Pharmacokinetic interactions of drugs with St John's wort

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Polyphenols: food sources and bioavailability

1 reference

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29 September 2017

Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Liver function test abnormalities in users of aqueous kava extracts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Multiple doses of saw palmetto (Serenoa repens) did not alter cytochrome P450 2D6 and 3A4 activity in normal volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Multiple-Dose Administration of Ginkgo biloba Did Not Affect Cytochrome P-450 2D6 or 3A4 Activity in Normal Volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Drug-herb interaction among commonly used conventional medicines: a compendium for health care professionals

1 reference

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29 September 2017

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Effect of short-term administration of garlic supplements on single-dose ritonavir pharmacokinetics in healthy volunteers

1 reference

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29 September 2017

Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450.

1 reference

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29 September 2017

The effect of garlic supplements on the pharmacokinetics of saquinavir

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29 September 2017

St John's wort, a herbal antidepressant, activates the steroid X receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

29 September 2017

Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial

1 reference

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27 June 2018

In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

27 June 2018

The involvement of P-glycoprotein in berberine absorption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

27 June 2018

In vitro approaches to predicting drug interactions in vivo.

1 reference

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27 June 2018

Drug interaction potential of soy extract and Panax ginseng

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.200600300

21 January 2018

Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers.

1 reference

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4 September 2018

Factors associated with dietary supplement use among prescription medication users

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

4 September 2018

Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

4 September 2018

Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

4 September 2018

Elderly herbal supplement users less satisfied with medical care than nonusers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

4 September 2018

Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

4 September 2018

Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis

1 reference

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4 September 2018

Assessment of in vivo CYP2D6 activity: differential sensitivity of commonly used probes to urine pH.

1 reference

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4 September 2018

Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction.

1 reference

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4 September 2018

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4 September 2018

The interaction between St John's wort and an oral contraceptive

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4 September 2018

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1 reference

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4 September 2018

Influence of Goldenseal Root on the Pharmacokinetics of Indinavir

1 reference

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4 September 2018

Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

4 September 2018

Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

4 September 2018

Coadministration of milk thistle and indinavir in healthy subjects

1 reference

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4 September 2018

In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products

1 reference

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4 September 2018

Extraction of nutraceuticals from milk thistle: part II. Extraction with organic solvents.

1 reference

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4 September 2018

Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices

1 reference

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4 September 2018

Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.

1 reference

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4 September 2018

Inhibition of human cytochrome P450 activities by kava extract and kavalactones

1 reference

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4 September 2018

Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562884

4 September 2018

Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity

1 reference

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4 September 2018

Determining hyperforin and hypericin content in eight brands of St. John's wort.

1 reference

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4 September 2018

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1 reference

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4 September 2018

The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

1 reference

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4 September 2018

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1 reference

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4 September 2018

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1 reference

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4 September 2018

Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/18214849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18214849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug interaction between St. John's wort and cyclosporine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18214849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18214849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effects of silibinin on cytochrome P-450 enzymes in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18214849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved high-performance liquid chromatographic determination of debrisoquine and 4-hydroxydebrisoquine in human urine following direct injection

1 reference

https://pubmed.ncbi.nlm.nih.gov/18214849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Echinacea and truth in labeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18214849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absorption, distribution and excretion of berberine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18214849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo modulation of CYP enzymes by quinidine and rifampin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18214849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of major active components in St. John's Wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18214849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kava hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18214849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Herbal supplements: a potential for drug interactions in transplant recipients

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https://pubmed.ncbi.nlm.nih.gov/18214849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/MNFR.200600300

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18214849%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18214849%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18214849%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

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