Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation (Q36929610)

17 August 2017

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title

Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation (English)

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17 August 2017

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Mei-Hui Hsu

1

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17 August 2017

Uzen Savas

series ordinal

2

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17 August 2017

Keith J Griffin

series ordinal

3

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17 August 2017

Eric F Johnson

series ordinal

4

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17 August 2017

language of work or name

English

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publication date

1 January 2007

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17 August 2017

Drug Metabolism Reviews

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17 August 2017

39

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17 August 2017

515-538

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17 August 2017

2-3

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Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain.

17 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

CYP4A11 is repressed by retinoic acid in human liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

CYP4B1: an enigmatic P450 at the interface between xenobiotic and endobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Potential for early involvement of CYP isoforms in aspects of human cadmium toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Characterization of the CYP4A11 gene, a second CYP4A gene in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

cDna cloning and expression of CYP4F12, a novel human cytochrome P450

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Oxidation of leukotrienes at the omega end: demonstration of a receptor for the 20-hydroxy derivative of leukotriene B4 on human neutrophils and implications for the analysis of leukotriene receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Profiling of hepatic gene expression in rats treated with fibric acid analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Troglitazone inhibits expression of the phosphoenolpyruvate carboxykinase gene by an insulin-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

CYP4V2 mutations in two Japanese patients with Bietti's crystalline dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Protein sensors for membrane sterols

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Molecular, enzymatic, and regulatory characterization of rat kidney cytochromes P450 4A2 and 4A3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

A transgenic mouse expressing human CYP4B1 in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Clinical and molecular findings in three Japanese patients with crystalline retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Sexual dimorphism and tissue specificity in the expression of CYP4F forms in Sprague Dawley rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Renal localization, expression, and developmental regulation of P450 4F cytochromes in three substrains of spontaneously hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Inflammatory prompts produce isoform-specific changes in the expression of leukotriene B(4) omega-hydroxylases in rat liver and kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Cytochrome P450 4F subfamily: at the crossroads of eicosanoid and drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Expression and induction of CYP4F subfamily in human leukocytes and HL60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Characterization of phytanic acid omega-hydroxylation in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Omega-hydroxylation of phytanic acid in rat liver microsomes: implications for Refsum disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor ex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Characterization of Bietti crystalline dystrophy patients with CYP4V2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Recessive mutations in the CYP4V2 gene in East Asian and Middle Eastern patients with Bietti crystalline corneoretinal dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Bietti crystalline corneoretinal dystrophy associated with CYP4V2 gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Gene nomenclature by default, or BLASTing to Babel

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Cytochrome P450 4A fatty acid omega hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Late onset neurological phenotype of the X-ALD gene inactivation in mice: a mouse model for adrenomyeloneuropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Peroxisomal lipid metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

A global perspective on cadmium pollution and toxicity in non-occupationally exposed population

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Conditional regulation of the human CYP4X1 and CYP4Z1 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Co-localization of COX-2, CYP4F8, and mPGES-1 in epidermis with prominent expression of CYP4F8 mRNA in psoriatic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Screening for mutations in CYP4V2 gene in Japanese patients with Bietti's crystalline corneoretinal dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

CYP4 isoform specificity in the omega-hydroxylation of phytanic acid, a potential route to elimination of the causative agent of Refsum's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Contribution of CYP4A8 to the formation of 20-hydroxyeicosatetraenoic acid from arachidonic acid in rat kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Xenobiotic-metabolizing enzymes in human lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701468573

10.1080/03602530701468573

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference