Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCδ pathway in human articular chondrocytes (Q36934976)

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scientific article published on September 2012

Language	Label	Description	Also known as
English	Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCδ pathway in human articular chondrocytes	scientific article published on September 2012

Statements

scholarly article

1 reference

Europe PubMed Central

17 August 2017

Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCδ pathway in human articular chondrocytes (English)

1 reference

Europe PubMed Central

17 August 2017

author name string

Dongyao Yan

1

1 reference

Europe PubMed Central

17 August 2017

Di Chen

2

1 reference

Europe PubMed Central

17 August 2017

Hee-Jeong Im

3

1 reference

Europe PubMed Central

17 August 2017

publication date

1 September 2012

1 reference

Europe PubMed Central

17 August 2017

Journal of Cellular Biochemistry

1 reference

Europe PubMed Central

17 August 2017

113

1 reference

Europe PubMed Central

17 August 2017

9

1 reference

Europe PubMed Central

17 August 2017

2856-2865

1 reference

Europe PubMed Central

17 August 2017

The pathophysiologic role of the protein kinase Cδ pathway in the intervertebral discs of rabbits and mice: in vitro, ex vivo, and in vivo studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684697

29 September 2017

Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684697

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Developments in the scientific understanding of osteoarthritis

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Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis

1 reference

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29 September 2017

Action of fibroblast growth factor-2 on the intervertebral disc

1 reference

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Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes

1 reference

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Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile.

1 reference

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Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes

1 reference

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Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family

1 reference

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Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model

1 reference

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p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes.

1 reference

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Runx2 phosphorylation induced by fibroblast growth factor-2/protein kinase C pathways

1 reference

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Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes

1 reference

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NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments

1 reference

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The impact of osteoarthritis: implications for research

1 reference

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Promotion and attenuation of FGF signaling through the Ras-MAPK pathway

1 reference

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Inhibitory Effects of Insulin-like Growth Factor-1 and Osteogenic Protein-1 on Fibronectin Fragment- and Interleukin-1β-stimulated Matrix Metalloproteinase-13 Expression in Human Chondrocytes

1 reference

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The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2

1 reference

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29 September 2017

Comparative gene expression profiling of normal and degenerative discs: analysis of a rabbit annular laceration model

1 reference

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29 September 2017

Metalloproteases and inhibitors in arthritic diseases

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29 September 2017

The role of the chondrocyte in osteoarthritis

1 reference

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29 September 2017

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

1 reference

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Identification of Ras farnesyltransferase inhibitors by microbial screening

1 reference

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29 September 2017

Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis

1 reference

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Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684697

4 September 2018

Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684697

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A spatial and temporal map of FGF/Erk1/2 activity and response repertoires in the early chick embryo.

1 reference

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Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.

1 reference

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Prolonged treatment of human osteoarthritic chondrocytes with insulin-like growth factor-I stimulates proteoglycan synthesis but not proteoglycan matrix accumulation in alginate cultures.

1 reference

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Signaling specificities of fibroblast growth factor receptors in early Xenopus embryo.

1 reference

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In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22488450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc

1 reference

https://pubmed.ncbi.nlm.nih.gov/22488450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of interleukin-1 on proteoglycan metabolism of rabbit annulus fibrosus cells cultured in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/22488450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22488450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of degenerative morphological changes in the joints of the lower extremity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22488450

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based on heuristic

inferred from PubMed ID database lookup

Collagenase-1 and collagenase-3 synthesis in normal and early experimental osteoarthritic canine cartilage: an immunohistochemical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22488450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/JCB.24160

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

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