Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells (Q36937029)

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scientific article published on August 2013

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English	Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells	scientific article published on August 2013

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scholarly article

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23 February 2020

Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells (English)

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23 February 2020

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metastatic breast cancer

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2

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23 February 2020

Andre J van Wijnen

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Andre J van Wijnen

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23 February 2020

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Gary S Stein

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Jane B Lian

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23 February 2020

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Janet L Stein

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Sayyed K. Zaidi

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Sayyed K Zaidi

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23 February 2020

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Sandhya Pande

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23 February 2020

Srivatsan Padmanabhan

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Srivatsan Padmanabhan

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23 February 2020

publication date

1 August 2013

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23 February 2020

Journal of Cellular Physiology

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23 February 2020

228

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23 February 2020

8

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23 February 2020

1784-1792

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23 February 2020

describes a project that uses

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11 June 2022

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FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers

1 reference

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29 September 2017

Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility

1 reference

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29 September 2017

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

1 reference

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29 September 2017

Metastatic bone disease: role of transcription factors and future targets

1 reference

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29 September 2017

Synergism between Wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase/Akt/RUNX2 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade

1 reference

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29 September 2017

Post-translational Regulation of Runx2 in Bone and Cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression

1 reference

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29 September 2017

Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer.

1 reference

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29 September 2017

Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

An actin-binding protein Girdin regulates the motility of breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Akt1 in osteoblasts and osteoclasts controls bone remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

AKT/PKB signaling: navigating downstream

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Roles of AKT signal in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Alterations in intranuclear localization of Runx2 affect biological activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

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29 September 2017

Runx2/Cbfa1: A Multifunctional Regulator of Bone Formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

29 September 2017

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

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29 September 2017

Use of an oriented peptide library to determine the optimal substrates of protein kinases

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29 September 2017

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

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29 September 2017

Interactions between extracellular signal-regulated kinase 1/2 and p38 MAP kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity

1 reference

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27 June 2018

A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3685436

27 June 2018

Runx2 in human breast carcinoma: its potential roles in cancer progression.

1 reference

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4 September 2018

Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells.

1 reference

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4 September 2018

Smad3 interacts with JunB and Cbfa1/Runx2 for transforming growth factor-beta1-stimulated collagenase-3 expression in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FJCP.24339

21 January 2018

Phosphatidylinositol 3-kinase/AKT signalling pathway components in human breast cancer: clinicopathological correlations

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/23389849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/JCP.24339

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23 February 2020

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23 February 2020

1 reference

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23 February 2020

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