TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2 (Q36946967)

17 August 2017

TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2 (English)

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17 August 2017

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Gary M Wildey

3

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Jeffery D. Molkentin

object named as

Jeffery Molkentin

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author name string

Sneha Ramesh

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17 August 2017

Xiao-Jun Qi

2

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17 August 2017

Janet Robinson

4

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17 August 2017

John Letterio

6

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17 August 2017

Philip H Howe

7

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17 August 2017

15 August 2008

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17 August 2017

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17 August 2017

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17 August 2017

990-997

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describes a project that uses

17 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2572119/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

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DUSP meet immunology: dual specificity MAPK phosphatases in control of the inflammatory response

29 September 2017

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Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

29 September 2017

1 reference

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Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis

29 September 2017

1 reference

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Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2.

29 September 2017

1 reference

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Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572119

Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells

29 September 2017

1 reference

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Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

29 September 2017

1 reference

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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

29 September 2017

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Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

29 September 2017

1 reference

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Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

29 September 2017

1 reference

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Smad3 potentiates transforming growth factor beta (TGFbeta )-induced apoptosis and expression of the BH3-only protein Bim in WEHI 231 B lymphocytes

29 September 2017

1 reference

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Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

29 September 2017

1 reference

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Structural organization of the rat mitogen-activated protein kinase phosphatase 2 gene

29 September 2017

1 reference

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Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors

29 September 2017

1 reference

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BH3-Only proteins-essential initiators of apoptotic cell death

29 September 2017

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

29 September 2017

1 reference

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The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

29 September 2017

1 reference

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

29 September 2017

1 reference

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The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

29 September 2017

1 reference

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

29 September 2017

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Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells

29 September 2017

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Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

29 September 2017

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Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

29 September 2017

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18704116

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bcl-x L blocks mitochondrial multiple conductance channel activation and inhibits 6-OHDA-induced death in SH-SY5Y cells

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOR.2008.158

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/EMBOR.2008.158

1 reference

17 August 2017

1 reference

17 August 2017

PubMed publication ID

18704116

1 reference