Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir. (Q36950587)

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25 January 2020

title

Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir (English)

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25 January 2020

3

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25 January 2020

author name string

Chengwei Li

1

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25 January 2020

Debra C Quenelle

2

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25 January 2020

John C Drach

4

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25 January 2020

Jiri Zemlicka

5

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25 January 2020

language of work or name

English

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publication date

20 February 2012

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Bioorganic & Medicinal Chemistry

25 January 2020

published in

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25 January 2020

volume

20

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25 January 2020

issue

8

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25 January 2020

page(s)

2669-2674

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Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies

25 January 2020

cites work

1 reference

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New developments in the management of cytomegalovirus infection after solid organ transplantation

29 September 2017

1 reference

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Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine

29 September 2017

1 reference

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In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication

29 September 2017

1 reference

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Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections

29 September 2017

1 reference

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Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro

29 September 2017

1 reference

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6-Deoxyacyclovir: a xanthine oxidase-activated prodrug of acyclovir

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690936

Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection.

29 September 2017

1 reference

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Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690936

Synthesis and biological activity of 2-aminopurine methylenecyclopropane analogues of nucleosides

4 September 2018

1 reference

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Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-(14)C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690936

Aldehyde oxidase from rabbit liver: specificity toward purines and their analogs

4 September 2018

1 reference

12 December 2020

A515U: a prodrug of acyclovir with increased oral bioavailability

1 reference

12 December 2020

Prodrugs of the selective antiherpesvirus agent 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine (BRL 39123) with improved gastrointestinal absorption properties

1 reference

12 December 2020

Metabolism and pharmacokinetics of a double prodrug of ganciclovir in the rat and monkey

1 reference

12 December 2020

10.1016/J.BMC.2012.02.031

Identifiers

DOI

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25 January 2020

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25 January 2020

PubMed publication ID

22417649

1 reference