Genetic analysis of resistance to viral infection (Q36950910)

17 August 2017

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title

Genetic analysis of resistance to viral infection (English)

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17 August 2017

3

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17 August 2017

7

Shizuo Akira

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Bruce Beutler

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1

object named as

Bruce Beutler

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17 August 2017

2

Celine Eidenschenk

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17 August 2017

4

Jean-Luc Imler

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17 August 2017

Osamu Takeuchi

5

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PubMed ID

17893693

17 August 2017

Jules A Hoffmann

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6

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17 August 2017

1 October 2007

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Nature Reviews Immunology

17 August 2017

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17 August 2017

7

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17 August 2017

10

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17 August 2017

753-766

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The challenge of emerging and re-emerging infectious diseases

17 August 2017

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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

31 March 2020

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Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus

31 March 2020

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Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway

31 March 2020

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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

31 March 2020

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

31 March 2020

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Self-assembled hexa-peri-hexabenzocoronene graphitic nanotube

31 March 2020

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A Toll-like receptor recognizes bacterial DNA

31 March 2020

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Toll-like receptor 3 promotes cross-priming to virus-infected cells.

31 March 2020

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Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

31 March 2020

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Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

31 March 2020

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Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

31 March 2020

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A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha

31 March 2020

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Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.

31 March 2020

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Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner.

31 March 2020

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Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

31 March 2020

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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

31 March 2020

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Herpes simplex virus encephalitis in human UNC-93B deficiency

31 March 2020

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The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

31 March 2020

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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

31 March 2020

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

31 March 2020

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RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

31 March 2020

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Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

31 March 2020

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Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

31 March 2020

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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

31 March 2020

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Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

31 March 2020

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IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

31 March 2020

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Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

31 March 2020

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IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9

31 March 2020

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Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

31 March 2020

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Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells

31 March 2020

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Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.

31 March 2020

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m7G5′ppp5′GmpCpUp at the 5′ terminus of reovirus messenger RNA

31 March 2020

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

31 March 2020

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mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

31 March 2020

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Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

31 March 2020

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The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

31 March 2020

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Cell type-specific involvement of RIG-I in antiviral response

31 March 2020

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

31 March 2020

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Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

31 March 2020

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5'-Triphosphate RNA is the ligand for RIG-I

31 March 2020

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RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

31 March 2020

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A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

31 March 2020

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TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

31 March 2020

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Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses

31 March 2020

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

31 March 2020

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

31 March 2020

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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

31 March 2020

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VISA is an adapter protein required for virus-triggered IFN-beta signaling

31 March 2020

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Essential role of IPS-1 in innate immune responses against RNA viruses

31 March 2020

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The specific and essential role of MAVS in antiviral innate immune responses

31 March 2020

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A FADD-dependent innate immune mechanism in mammalian cells

31 March 2020

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Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA

31 March 2020

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Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

31 March 2020

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Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection

31 March 2020

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Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

31 March 2020

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Inhibition of NK cells by murine CMV-encoded class I MHC homologue m144.

31 March 2020

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NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules

31 March 2020

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NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145.

31 March 2020

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Selective down-regulation of the NKG2D ligand H60 by mouse cytomegalovirus m155 glycoprotein

31 March 2020

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A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface

31 March 2020

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The glycoprotein gp48 of murine cytomegalovirusL proteasome-dependent cytosolic dislocation and degradation

31 March 2020

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The immunoevasive function encoded by the mouse cytomegalovirus gene m152 protects the virus against T cell control in vivo

31 March 2020

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Viral interference with antigen presentation

31 March 2020

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Antigens and immunoevasins: opponents in cytomegalovirus immune surveillance

31 March 2020

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Identification of a mouse cytomegalovirus gene selectively targeting CD86 expression on antigen-presenting cells.

31 March 2020

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Role of murine cytomegalovirus US22 gene family members in replication in macrophages

31 March 2020

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Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway

31 March 2020

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Murine cytomegalovirus m142 and m143 are both required to block protein kinase R-mediated shutdown of protein synthesis

31 March 2020

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Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10

31 March 2020

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Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen

31 March 2020

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Vital involvement of a natural killer cell activation receptor in resistance to viral infection.

31 March 2020

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Recognition of a virus-encoded ligand by a natural killer cell activation receptor

31 March 2020

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Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

31 March 2020

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KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions

31 March 2020

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Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

31 March 2020

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DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase

31 March 2020

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Analysis of the MCMV resistome by ENU mutagenesis

31 March 2020

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Ikaros is required for plasmacytoid dendritic cell differentiation

31 March 2020

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TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

31 March 2020

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Functional interactions between dendritic cells and NK cells during viral infection

31 March 2020

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Perforin and Granzymes Have Distinct Roles in Defensive Immunity and Immunopathology

31 March 2020

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Linking albinism and immunity: the secrets of secretory lysosomes

31 March 2020

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Use of expression constructs to dissect the functional domains of the CHS/beige protein: identification of multiple phenotypes

31 March 2020

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Analysis of the lysosomal storage disease Chediak-Higashi syndrome

31 March 2020

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The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins

31 March 2020

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Lytic granules, secretory lysosomes and disease

31 March 2020

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Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

31 March 2020

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Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

31 March 2020

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Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis

31 March 2020

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SNAREing immunity: the role of SNAREs in the immune system

31 March 2020

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Cytotoxic T lymphocyte exocytosis: bring on the SNAREs!

31 March 2020

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Requisite H2k role in NK cell-mediated resistance in acute murine cytomegalovirus-infected MA/My mice

31 March 2020

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Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection

31 March 2020

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The immune response of Drosophila

31 March 2020

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Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis

31 March 2020

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Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition

31 March 2020

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31 March 2020

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The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila

31 March 2020

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The roles of JAK/STAT signaling in Drosophila immune responses

31 March 2020

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Characterization of two mosquito STATs, AaSTAT and CtSTAT. Differential regulation of tyrosine phosphorylation and DNA binding activity by lipopolysaccharide treatment and by Japanese encephalitis virus infection

31 March 2020

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White spot syndrome virus annexes a shrimp STAT to enhance expression of the immediate-early gene ie1.

31 March 2020

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Inhibitor kappaB-like proteins from a polydnavirus inhibit NF-kappaB activation and suppress the insect immune response

31 March 2020

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The Toll pathway is important for an antiviral response in Drosophila

31 March 2020

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Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

31 March 2020

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Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila

31 March 2020

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RNA interference directs innate immunity against viruses in adult Drosophila

31 March 2020

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The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster

31 March 2020

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RNAi is an antiviral immune response against a dsRNA virus in Drosophila melanogaster.

31 March 2020

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Natural selection drives extremely rapid evolution in antiviral RNAi genes.

31 March 2020

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Induction and suppression of RNA silencing by an animal virus

31 March 2020

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Dual modes of RNA-silencing suppression by Flock House virus protein B2.

31 March 2020

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The relationship between the flamenco gene and gypsy in Drosophila: how to tame a retrovirus

31 March 2020

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Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila

31 March 2020

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A novel repeat-associated small interfering RNA-mediated silencing pathway downregulates complementary sense gypsy transcripts in somatic cells of the Drosophila ovary

31 March 2020

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MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline

31 March 2020

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A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.

31 March 2020

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Developmentally regulated piRNA clusters implicate MILI in transposon control

31 March 2020

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Hierarchical action and inhibition of plant Dicer-like proteins in antiviral defense.

31 March 2020

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DICER-LIKE 4 is required for RNA interference and produces the 21-nucleotide small interfering RNA component of the plant cell-to-cell silencing signal

31 March 2020

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Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila

31 March 2020

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The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing

31 March 2020

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A cellular microRNA mediates antiviral defense in human cells

31 March 2020

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Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression

31 March 2020

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MicroRNAs and immunity: tiny players in a big field

31 March 2020

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Is RNA interference involved in intrinsic antiviral immunity in mammals?

31 March 2020

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Initial sequencing and analysis of the human genome

31 March 2020

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Common sequence at the 5' ends of the segmented RNA genomes of influenza A and B viruses

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Pathogenesis of murine cytomegalovirus infection in natural killer cell-depleted mice

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI2174

1 reference

17 August 2017

1 reference

PubMed ID

17893693