Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice (Q36951646)

17 August 2017

Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice (English)

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17 August 2017

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Coagulation factor VIII

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hemophilia A

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author name string

Vivek S Purohit

series ordinal

1

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17 August 2017

C Russell Middaugh

series ordinal

2

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17 August 2017

Sathyamangalam V Balasubramanian

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 February 2006

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Journal of Pharmaceutical Sciences

17 August 2017

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17 August 2017

95

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17 August 2017

2

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17 August 2017

358-371

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Aggregation kinetics of recombinant human FVIII (rFVIII)

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Lipid binding region (2303-2332) is involved in aggregation of recombinant human FVIII (rFVIII)

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Lower inhibitor development in hemophilia A mice following administration of recombinant factor VIII-O-phospho-L-serine complex

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Inhibitors in haemophilia: pathophysiology

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Environmental and genetic factors influencing inhibitor development

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Immunogenicity of therapeutic proteins: clinical implications and future prospects

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Bioequivalence and the immunogenicity of biopharmaceuticals

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Immunogenicity of rDNA-derived pharmaceuticals

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

9 September 2017

Factor VIII inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

T cell-dependent B cell activation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Molecular cloning of a cDNA encoding human antihaemophilic factor

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Structure of human factor VIII

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

The role of pharmacokinetics in the development of biotechnologically derived agents

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Priming of cytotoxic T lymphocytes by five heat-aggregated antigens in vivo: conditions, efficiency, and relation to antibody responses

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Inhibitor antibody development and T cell response to human factor VIII in murine hemophilia A.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Capture and processing of exogenous antigens for presentation on MHC molecules.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

The potential impact of recombinant factor VIII on hemophilia care and the demand for blood and blood products

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Formulation design of acidic fibroblast growth factor

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Protein conformation significantly influences immune responses to prion protein.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Heat denaturation affects the ProDer p 1 IgE reactivity and downregulates the development of the specific allergic response

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Aggregate content influences the Th1/Th2 immune response to influenza vaccine: evidence from a mouse model

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Correlation of rFVIII inactivation with aggregation in solution

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Von Willebrand factor modulates factor VIII immunogenicity: comparative study of different factor VIII concentrates in a haemophilia A mouse model.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Conformational origin of the aggregation of recombinant human factor VIII.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Factor VIII immunogenicity

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Characterization of aggregates of recombinant human factor VIII by size-exclusion chromatography and immunoassay.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574426

Factors limiting the immunogenicity of HIV-1 gp120 envelope glycoproteins

4 September 2018

1 reference

12 December 2020

Characterization of antibodies induced by human factor VIII in a murine knockout model of hemophilia A

1 reference

12 December 2020

Mechanism of the immune response to human factor VIII in murine hemophilia A

1 reference

12 December 2020

Single cell analysis of factor VIII-specific T cells in hemophilic mice after treatment with human factor VIII

1 reference

12 December 2020

Distribution of Th1- and Th2-induced anti-factor VIII IgG subclasses in congenital and acquired hemophilia patients

1 reference

12 December 2020

The immunogenicity of biopharmaceuticals. Lessons learned and consequences for protein drug development

1 reference

12 December 2020

A caution on the use of murine hemophilia models for comparative immunogenicity studies of FVIII products with different protein compositions

1 reference

12 December 2020

The Nijmegen modification of the Bethesda assay for factor VIII:C inhibitors: improved specificity and reliability

1 reference

12 December 2020

A comparison of the immunogenicity of the native and denatured forms of a protein

1 reference

12 December 2020

Immunological parameters associated with antigenic competition in a multivalent footrot vaccine

1 reference

12 December 2020

Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-alpha) in normal and transgenic mice

1 reference

12 December 2020

Immunodominant T-cell epitopes in the factor VIII C2 domain are located within an inhibitory antibody binding site

1 reference

12 December 2020

Role of aggregated human growth hormone (hGH) in development of antibodies to hGH

1 reference

12 December 2020

Synthesis, processing, and secretion of recombinant human factor VIII expressed in mammalian cells

1 reference

12 December 2020

Reconstitution of human factor VIII from isolated subunits

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12 December 2020

Factor VIII structure and function

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12 December 2020

Antigen stability controls antigen presentation

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12 December 2020

Identifiers

DOI

10.1002/JPS.20529

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17 August 2017

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17 August 2017

PubMed publication ID

16372314

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