Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid (Q36952136)

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scientific article published on 04 June 2008

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English	Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid	scientific article published on 04 June 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

1 reference

Europe PubMed Central

Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Marilyn E Morris

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Melanie A Felmlee

2

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Europe PubMed Central

PMC publication ID

17 August 2017

language of work or name

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publication date

4 June 2008

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Europe PubMed Central

PMC publication ID

17 August 2017

The AAPS Journal

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Europe PubMed Central

PMC publication ID

17 August 2017

10

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Europe PubMed Central

PMC publication ID

17 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

311-321

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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1 reference

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From the street to the brain: neurobiology of the recreational drug gamma-hydroxybutyric acid

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1 reference

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Gamma hydroxybutyric acid (GHB) intoxication

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Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1

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Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ

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GHB: an important pharmacologic and clinical update

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Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters

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Evidence for a G protein-coupled gamma-hydroxybutyric acid receptor

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CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

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Monocarboxylate transporter expression in mouse brain

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9 September 2017

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cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1.

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cDNA cloning of MCT1, a monocarboxylate transporter from rat skeletal muscle

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29 September 2017

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Inhibitory effects of statins on human monocarboxylate transporter 4.

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29 September 2017

Transport of lactate and other monocarboxylates across mammalian plasma membranes

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29 September 2017

Monocarboxylate transport in erythrocytes

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29 September 2017

The gamma-hydroxybutyrate signalling system in brain: organization and functional implications.

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29 September 2017

Characterization of monocarboxylate transport in human kidney HK-2 cells

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27 June 2018

Expression of monocarboxylate transporters in rat ocular tissues

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27 June 2018

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27 June 2018

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27 June 2018

Dose-dependent absorption and elimination of gamma-hydroxybutyric acid in healthy volunteers.

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27 June 2018

A high-affinity, Na+-dependent uptake system for gamma-hydroxybutyrate in membrane vesicles prepared from rat brain.

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27 June 2018

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27 June 2018

Dose-dependent pharmacokinetics and hypnotic effects of sodium gamma-hydroxybutyrate in the rat

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27 June 2018

PPARalpha agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestine

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4 September 2018

Alternative promoter usage and alternative splicing contribute to mRNA heterogeneity of mouse monocarboxylate transporter 2.

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4 September 2018

The synaptic scaffolding protein Delphilin interacts with monocarboxylate transporter 2.

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4 September 2018

Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway

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4 September 2018

Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo.

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4 September 2018

Testosterone increases lactate transport, monocarboxylate transporter (MCT) 1 and MCT4 in rat skeletal muscle.

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4 September 2018

Potential gamma-hydroxybutyric acid (GHB) drug interactions through blood-brain barrier transport inhibition: a pharmacokinetic simulation-based evaluation

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4 September 2018

Transport of gamma-hydroxybutyrate in rat kidney membrane vesicles: Role of monocarboxylate transporters.

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4 September 2018

Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex

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4 September 2018

Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway

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4 September 2018

Functional characterization of human monocarboxylate transporter 6 (SLC16A5).

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4 September 2018

Enteropathogenic Escherichia coli inhibits butyrate uptake in Caco-2 cells by altering the apical membrane MCT1 level

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4 September 2018

pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers.

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4 September 2018

Expression and membrane localization of MCT isoforms along the length of the human intestine

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4 September 2018

Renal clearance of gamma-hydroxybutyric acid in rats: increasing renal elimination as a detoxification strategy

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4 September 2018

Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate

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4 September 2018

GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier

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4 September 2018

The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter

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4 September 2018

Gamma-hydroxybutyrate serum levels and clinical syndrome after severe overdose

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4 September 2018

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4 September 2018

A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is co-localized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574616

4 September 2018

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574616

4 September 2018

Determination of transport kinetics of chick MCT3 monocarboxylate transporter from retinal pigment epithelium by expression in genetically modified yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574616

4 September 2018

Role of the monocarboxylic acid transport system in the intestinal absorption of an orally active beta-lactam prodrug: carindacillin as a model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574616

4 September 2018

Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574616

4 September 2018

Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574616

4 September 2018

Effect of moderate or severe liver dysfunction on the pharmacokinetics of gamma-hydroxybutyric acid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574616

4 September 2018

Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettré tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2574616

4 September 2018

Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18523892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved pharmacological activity via pro-drug modification: comparative pharmacokinetics of sodium gamma-hydroxybutyrate and gamma-butyrolactone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18523892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absorption of sodium gamma-hydroxybutyrate and its prodrug gamma-butyrolactone: relationship between in vitro transport and in vivo absorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/18523892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/18523892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal brush-border transport of the oral cephalosporin antibiotic, cefdinir, mediated by dipeptide and monocarboxylic acid transport systems in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/18523892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18523892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proton-cotransport of pravastatin across intestinal brush-border membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/18523892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular and subcellular expression of monocarboxylate transporters in the pigment epithelium and retina of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18523892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of intestinal absorption of an orally active beta-lactam prodrug: uptake and transport of carindacillin in Caco-2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18523892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1208/S12248-008-9035-6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

0 references

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