Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues (Q36956360)

17 August 2017

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title

Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues (English)

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17 August 2017

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Brian F Gage

1

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PubMed ID

17906972

17 August 2017

Lawrence J Lesko

series ordinal

2

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17 August 2017

1 October 2007

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Journal of Thrombosis and Thrombolysis

17 August 2017

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17 August 2017

25

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17 August 2017

45-51

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17 August 2017

1

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https://scigraph.springernature.com/pub.10.1007/s11239-007-0104-y

17 August 2017

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cites work

Risk factors for complications of chronic anticoagulation. A multicenter study. Warfarin Optimized Outpatient Follow-up Study Group

1 reference

https://api.crossref.org/works/10.1007%2FS11239-007-0104-Y

Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism: a meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11239-007-0104-Y

Comparison of an age adjusted warfarin loading protocol with empirical dosing and Fennerty's protocol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11239-007-0104-Y

Warfarin therapy for an octogenarian who has atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11239-007-0104-Y

Aging and the anticoagulant response to warfarin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11239-007-0104-Y

Managing oral anticoagulant therapy

21 January 2018

1 reference

12 December 2020

Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe

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12 December 2020

Clinical risk factors and timing of recurrent venous thromboembolism during the initial 3 months of anticoagulant therapy

1 reference

12 December 2020

A new regimen for starting warfarin therapy in out-patients

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12 December 2020

American Heart Association/American College of Cardiology Foundation Guide to Warfarin Therapy

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12 December 2020

Missense mutations at ALA-10 in the factor IX propeptide: an insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy.

1 reference

12 December 2020

Anticoagulant-related bleeding: clinical epidemiology, prediction, and prevention

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12 December 2020

Population variation in VKORC1 haplotype structure

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12 December 2020

Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy

1 reference

12 December 2020

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

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12 December 2020

A comparison of a low-dose warfarin induction regimen with the modified Fennerty regimen in elderly inpatients.

1 reference

12 December 2020

Flexible induction dose regimen for warfarin and prediction of maintenance dose

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12 December 2020

Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin

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12 December 2020

Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors.

1 reference

12 December 2020

The genetics of vitamin K antagonists

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12 December 2020

Trends in the prevalence and management of atrial fibrillation in general practice in England and Wales, 1994-1998: analysis of data from the general practice research database

1 reference

12 December 2020

A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance

1 reference

12 December 2020

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences

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12 December 2020

Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype.

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12 December 2020

Major bleeding after hospitalization for deep-venous thrombosis.

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12 December 2020

Main haplotypes and mutational analysis of vitamin K epoxide reductase (VKORC1) in a Swedish population: a retrospective analysis of case records

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12 December 2020

Genetic modulation of oral anticoagulation with warfarin

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12 December 2020

Selecting patients with atrial fibrillation for anticoagulation: stroke risk stratification in patients taking aspirin

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12 December 2020

Interindividual variability in sensitivity to warfarin--Nature or nurture?

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12 December 2020

Genetic-based dosing in orthopedic patients beginning warfarin therapy.

1 reference

12 December 2020

Combined genetic profiles of components and regulators of the vitamin K-dependent gamma-carboxylation system affect individual sensitivity to warfarin

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12 December 2020

A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk

1 reference

12 December 2020

Initiating and Maintaining Patients on Warfarin Anticoagulation: The Importance of Monitoring

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12 December 2020

A mutation in the propeptide of Factor IX leads to warfarin sensitivity by a novel mechanism

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12 December 2020

Genetic association between sensitivity to warfarin and expression of CYP2C9*3

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12 December 2020

A multicomponent intervention to prevent major bleeding complications in older patients receiving warfarin. A randomized, controlled trial

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12 December 2020

Use of pharmacogenetics and clinical factors to predict the maintenance dose of warfarin.

1 reference

12 December 2020

Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment.

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12 December 2020

Risk of osteoporotic fracture in elderly patients taking warfarin: results from the National Registry of Atrial Fibrillation 2.

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12 December 2020

The frequency and effects of cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin

1 reference

12 December 2020

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

1 reference

12 December 2020

The risk of overanticoagulation in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon

1 reference

12 December 2020

Implications of cytochrome P450 2C9 polymorphism on warfarin metabolism and dosing

1 reference

12 December 2020

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

1 reference

12 December 2020

Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy

1 reference

12 December 2020

Maternal and fetal sequelae of anticoagulation during pregnancy

1 reference

12 December 2020

Warfarin-induced impairment of cortical bone material quality and compensatory adaptation of cortical bone structure to mechanical stimuli

1 reference

12 December 2020

Tailoring warfarin induction doses to reflect individual and disease-specific factors.

1 reference

12 December 2020

Evaluation of warfarin initiation regimens in elderly inpatients

1 reference

12 December 2020

Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX, and X; proteins S and C; and gamma-glutamyl carboxylase) gene variants with warfarin sensitivity

1 reference

12 December 2020

Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose

1 reference

12 December 2020

Functional impact of CYP2C95, CYP2C96, CYP2C98, and CYP2C911 in vivo among black Africans

1 reference

12 December 2020

Comparisons between in-vitro and in-vivo metabolism of (S)-warfarin: catalytic activities of cDNA-expressed CYP2C9, its Leu359 variant and their mixture versus unbound clearance in patients with the corresponding CYP2C9 genotypes

1 reference

12 December 2020

CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: a HuGEnet systematic review and meta-analysis

1 reference

12 December 2020

Common VKORC1 and GGCX polymorphisms associated with warfarin dose

1 reference

12 December 2020

Identification of the gene for vitamin K epoxide reductase

1 reference

12 December 2020

Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation

1 reference

12 December 2020

Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study

1 reference

12 December 2020

10.1007/S11239-007-0104-Y

Identifiers

DOI

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17 August 2017

1 reference

PubMed ID

17906972