MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. (Q36967719)

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scientific article published on May 2000

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English	MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.	scientific article published on May 2000

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scholarly article

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6 November 2019

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration (English)

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6 November 2019

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4

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6 November 2019

7

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M Karin

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6 November 2019

author name string

Y Xia

1

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6 November 2019

C Makris

2

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6 November 2019

B Su

3

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6 November 2019

J Yang

5

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6 November 2019

G R Nemerow

6

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6 November 2019

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publication date

1 May 2000

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6 November 2019

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

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6 November 2019

97

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6 November 2019

5243-5248

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10

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6 November 2019

JNK2 and IKKbeta are required for activating the innate response to viral infection

1 reference

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MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes

1 reference

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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

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Phylogenetic perspectives in innate immunity

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

1 reference

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Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption

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Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase

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JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

1 reference

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ASK1 is essential for JNK/SAPK activation by TRAF2

1 reference

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

1 reference

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Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting [...]

1 reference

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29 September 2017

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

1 reference

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

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Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

1 reference

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Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

1 reference

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Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase

1 reference

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IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

1 reference

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29 September 2017

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

1 reference

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29 September 2017

MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.

1 reference

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Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38

1 reference

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

1 reference

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Regulation of cell motility by mitogen-activated protein kinase

1 reference

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29 September 2017

Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway

1 reference

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29 September 2017

TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

1 reference

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Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

1 reference

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

1 reference

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The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase

1 reference

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

1 reference

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1 reference

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29 September 2017

Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK

1 reference

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29 September 2017

Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation

1 reference

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29 September 2017

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

1 reference

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A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

1 reference

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Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

1 reference

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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

1 reference

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29 September 2017

The stress-activated protein kinase subfamily of c-Jun kinases

1 reference

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29 September 2017

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1 reference

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Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1 reference

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Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

1 reference

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29 September 2017

Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B

1 reference

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Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

1 reference

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Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1 reference

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Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

1 reference

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Signaling mechanisms in growth factor-stimulated cell motility

1 reference

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Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis.

1 reference

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MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha.

1 reference

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MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton.

1 reference

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1 reference

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4 September 2018

Identifiers

10.1073/PNAS.97.10.5243

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6 November 2019

2000PNAS...97.5243X

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1 reference

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6 November 2019

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6 November 2019

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