Overproduction of Dihydrofolate Reductase and Gene Amplification in Methotrexate-Resistant Chinese Hamster Ovary Cells (Q36971834)

17 August 2017

Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells (English)

1 reference

17 August 2017

Overproduction of Dihydrofolate Reductase and Gene Amplification in Methotrexate-Resistant Chinese Hamster Ovary Cells (English)

1 reference

https://api.crossref.org/works/10.1128/MCB.2.3.275-285.1982

17 September 2023

1 reference

https://api.crossref.org/works/10.1128/MCB.2.3.275-285.1982

17 September 2023

author name string

W. F. Flintoff

1

1 reference

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17 September 2023

M. K. Weber

2

1 reference

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17 September 2023

C. R. Nagainis

3

1 reference

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17 September 2023

A. K. Essani

4

1 reference

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17 September 2023

D. Robertson

5

1 reference

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17 September 2023

W. Salser

6

1 reference

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17 September 2023

language of work or name

English

0 references

publication date

1 March 1982

1 reference

full work available at URL

17 August 2017

http://mcb.asm.org/cgi/content/abstract/2/3/275

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6287233

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/6287233/pdf/?tool=EBI

17 September 2023

file format

Portable Document Format

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6287233

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/6287233/?tool=EBI

17 September 2023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6287233

https://europepmc.org/articles/PMC369786

17 September 2023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6287233

https://europepmc.org/articles/PMC369786?pdf=render

17 September 2023

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6287233

https://journals.asm.org/doi/pdf/10.1128/mcb.2.3.275-285.1982

17 September 2023

1 reference

https://api.crossref.org/works/10.1128/MCB.2.3.275-285.1982

https://www.tandfonline.com/doi/pdf/10.1128/mcb.2.3.275-285.1982

17 September 2023

1 reference

https://api.crossref.org/works/10.1128/MCB.2.3.275-285.1982

Molecular and Cellular Biology

17 September 2023

published in

1 reference

17 August 2017

2

1 reference

17 August 2017

3

1 reference

17 August 2017

275-285

1 reference

Protein measurement with the Folin phenol reagent

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Microcell-mediated cotransfer of genes specifying methotrexate resistance, emetine sensitivity, and chromate sensitivity with Chinese hamster chromosome 2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Molecular cloning of Chinese hamster dihydrofolate reductase-specific cDNA and the identification of multiple dihydrofolate reductase mRNAs in antifolate-resistant Chinese hamster lung fibroblasts

29 September 2017

1 reference

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Transformation of mammalian cells with an amplifiable dominant-acting gene

29 September 2017

1 reference

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A membrane-filter technique for the detection of complementary DNA

29 September 2017

1 reference

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

29 September 2017

1 reference

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Hybridization of hamster cells with high and low folate reductase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

A Film Detection Method for Tritium-Labelled Proteins and Nucleic Acids in Polyacrylamide Gels

29 September 2017

1 reference

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Deoxyribonucleic acid polymerase associated with avian tumor viruses: secondary structure of the deoxyribonucleic acid product

29 September 2017

1 reference

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Detection of specific sequences among DNA fragments separated by gel electrophoresis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Quantitative Film Detection of 3H and 14C in Polyacrylamide Gels by Fluorography

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Metaphase chromosome anomaly: association with drug resistance and cell-specific products

29 September 2017

1 reference

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The development of resistance to methotrexate in a mouse melanoma cell line. I. Characterisation of the dihydrofolate reductases and chromosomes in sensitive and resistant cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

High resolution two-dimensional electrophoresis of proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Purification and properties of dihydrofolate reductase from methotrexate-sensitive and methotrexate-resistant Chinese hamster ovary cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Methotrexate-resistant Chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Selection of wild-type revertants from methotrexate-resistant cells containing an altered dihydrofolate reductase.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Purification, Properties, and Synthesis of Dihydrofolate Reductase from Wild Type and Methotrexate-resistant Hamster Cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Drug response, dihydrofolate reductase, and cytogenetics of amethopterin-resistant Chinese hamster cells in vitro.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Analysis of bacteriophage T7 early RNAs and proteins on slab gels

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Isolation and biochemical characterization of folate deficient mutants of chinese hamster cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Proposed banding nomenclature for the Chinese hamster chromosomes (Cricetulus griseus)

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Elevated dihydrofolate reductase messenger RNA levels in methotrexate-resistant BHK cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Gene amplification and drug resistance in cultured murine cells.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Chromosome stability in CHO cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

ISOLATION OF HIGH MOLECULAR WEIGHT DNA FROM HEMOPHILUS INFLUENZAE.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

Antifolate-resistant chinese hamster cells. Evidence from independently derived sublines for the overproduction of two dihydrofolate reductases encoded by different mRNAs.

4 September 2018

1 reference

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Structure and genomic organization of the mouse dihydrofolate reductase gene

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=369786

On the nature of a transport alteration determining resistance to amethopterin in the L1210 leukemia

4 September 2018

1 reference

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Isolation and characterization of the multiple forms of dihydrofolate reductase from methotrexate-resistant hamster cells.

4 September 2018

1 reference

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Two types of ribosome in mouse-hamster hybrid cells

4 September 2018

1 reference

12 December 2020

Two different species of dihydrofolate reductase in mammalian cells differentially resistant to amethopterin and methasquin

1 reference

12 December 2020

Altered regulation of the rate of synthesis of dihydrofolate reductase in methotrexate-resistant hamster cells

1 reference

12 December 2020

Messenger RNA for myosin polypeptides: isolation from single myogenic cell cultures

1 reference

12 December 2020

Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofoltate reductase

1 reference

12 December 2020

Chromosome loss is responsible for segregation at theHPRT locus in Chinese hamster cell hybrids

1 reference

12 December 2020

Antifolate-resistant Chinese hamster cells. Evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases

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12 December 2020

Detective transport of amethopterin (methotrexate) as a mechanism of resistance to the antimetabolite in L5178Y leukemic cells

1 reference

12 December 2020

1

32

1539

Albrecht A. M.

1972

1 reference

https://api.crossref.org/works/10.1128/MCB.2.3.275-285.1982

17 September 2023

5

32

152

Biedler J. L.

1972

1 reference

https://api.crossref.org/works/10.1128/MCB.2.3.275-285.1982

17 September 2023

41

28

75

Sirotnak F. M.

1968

1 reference

https://api.crossref.org/works/10.1128/MCB.2.3.275-285.1982

17 September 2023

Identifiers

10.1128/MCB.2.3.275

1 reference

17 August 2017

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6287233

17 September 2023

1 reference

17 August 2017

1 reference