ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity (Q36979971)

17 August 2017

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity (English)

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17 August 2017

7

Richard A Flavell

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17 August 2017

Jared M Odegard

1

1 reference

17 August 2017

Benjamin R Marks

2

1 reference

17 August 2017

Leah D DiPlacido

3

1 reference

17 August 2017

Amanda C Poholek

4

1 reference

17 August 2017

Dwight H Kono

5

1 reference

17 August 2017

Chen Dong

6

1 reference

17 August 2017

Joe Craft

8

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17 August 2017

language of work or name

English

0 references

publication date

3 November 2008

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Journal of Experimental Medicine

17 August 2017

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17 August 2017

205

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17 August 2017

12

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17 August 2017

2873-2886

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describes a project that uses

17 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2585848/fullTextXML

inferred from PubMed Central ID database lookup

cites work

A fundamental role for interleukin-21 in the generation of T follicular helper cells

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

29 September 2017

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Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration

29 September 2017

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T helper cell effector fates--who, how and where?

29 September 2017

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Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

29 September 2017

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B cell migration and interactions in the early phase of antibody responses

29 September 2017

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A two-step process for cytokine production revealed by IL-4 dual-reporter mice

29 September 2017

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Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

29 September 2017

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The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo

29 September 2017

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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

29 September 2017

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T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

29 September 2017

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Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice

29 September 2017

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Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation

29 September 2017

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Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells

29 September 2017

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Extrafollicular antibody responses

29 September 2017

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Ectopic LTαβ Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase

29 September 2017

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A critical role for IL-21 in regulating immunoglobulin production

29 September 2017

1 reference

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Separable effector T cell populations specialized for B cell help or tissue inflammation

29 September 2017

1 reference

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Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

ICOS is essential for effective T-helper-cell responses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

ICOS is critical for CD40-mediated antibody class switching

29 September 2017

1 reference

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ICOS co-stimulatory receptor is essential for T-cell activation and function

29 September 2017

1 reference

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CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function

29 September 2017

1 reference

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Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells

29 September 2017

1 reference

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T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching

29 September 2017

1 reference

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Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice

29 September 2017

1 reference

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Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle

29 September 2017

1 reference

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Control of inflammation, cytokine expression, and germinal center formation by BCL-6

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Functional diversity of helper T lymphocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Antigen-driven B cell differentiation in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

29 September 2017

1 reference

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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Treatment of murine lupus with monoclonal antibody to L3T4. II. Effects on immunohistopathology of thymus, spleen, and lymph node.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Unique gene expression program of human germinal center T helper cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Spontaneous formation of germinal centers in autoimmune mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Cutting edge: critical role of inducible costimulator in germinal center reactions

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2585848

Murine lupus in the absence of alpha beta T cells

20 October 2018

1 reference

12 December 2020

Follicular dendritic cell regulation of CXCR4-mediated germinal center CD4 T cell migration

1 reference

12 December 2020

Visualizing the onset and evolution of an autoantibody response in systemic autoimmunity

1 reference

12 December 2020

Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes

1 reference

12 December 2020

Cutting edge: germinal centers can be induced in the absence of T cells

1 reference

12 December 2020

IL-21 induces the apoptosis of resting and activated primary B cells

1 reference

12 December 2020

Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal center

1 reference

12 December 2020

Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help

1 reference

12 December 2020

Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs

1 reference

12 December 2020

Evolution of autoantibody responses via somatic hypermutation outside of germinal centers

1 reference

12 December 2020

Role of the H-2 haplotype in Fas-intact lupus-prone MRL mice: association with autoantibodies but not renal disease

1 reference

12 December 2020

Polyclonal B cell activation arises from different mechanisms in lupus-prone (NZB x NZW)F1 and MRL/MpJ-lpr/lpr mice

1 reference

12 December 2020

Anatomy of autoantibody production: dominant localization of antibody-producing cells to T cell zones in Fas-deficient mice

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20080840

1 reference

17 August 2017

1 reference

17 August 2017

1 reference