Endocrine functions of bone in mineral metabolism regulation. (Q36982323)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19033649%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

L Darryl Quarles

series ordinal

1

1 reference

17 August 2017

language of work or name

English

0 references

publication date

1 December 2008

1 reference

Journal of Clinical Investigation

17 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19033649%20AND%20SRC:MED&resulttype=core&format=json

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19033649%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

118

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19033649%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

3820-3828

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19033649%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

12

1 reference

FGFR3 and FGFR4 do not mediate renal effects of FGF23.

17 January 2020

cites work

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Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis

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Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling

29 September 2017

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A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism

29 September 2017

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Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro

29 September 2017

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betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c

29 September 2017

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Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia

29 September 2017

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Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP

29 September 2017

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Functional evolutionary history of the mouse Fgf gene family

29 September 2017

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Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

29 September 2017

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The parathyroid is a target organ for FGF23 in rats

29 September 2017

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A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis

29 September 2017

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Liver-specific activities of FGF19 require Klotho beta

29 September 2017

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Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

29 September 2017

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alpha-Klotho as a regulator of calcium homeostasis

29 September 2017

1 reference

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How fibroblast growth factor 23 works

29 September 2017

1 reference

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BetaKlotho is required for metabolic activity of fibroblast growth factor 21

29 September 2017

1 reference

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Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

29 September 2017

1 reference

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Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

29 September 2017

1 reference

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Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo

29 September 2017

1 reference

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Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals

29 September 2017

1 reference

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Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Klotho converts canonical FGF receptor into a specific receptor for FGF23

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis

29 September 2017

1 reference

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Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis

29 September 2017

1 reference

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Hypophosphatemia: an evidence-based approach to its clinical consequences and management

29 September 2017

1 reference

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Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi

29 September 2017

1 reference

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Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin

29 September 2017

1 reference

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Regulation of fibroblast growth factor-23 signaling by klotho

29 September 2017

1 reference

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SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis

29 September 2017

1 reference

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DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis

29 September 2017

1 reference

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Suppression of aging in mice by the hormone Klotho

29 September 2017

1 reference

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Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23

29 September 2017

1 reference

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Role of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidism

29 September 2017

1 reference

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Fibroblast growth factor-23 mutants causing familial tumoral calcinosis are differentially processed.

29 September 2017

1 reference

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Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease

29 September 2017

1 reference

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Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation

29 September 2017

1 reference

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An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.

29 September 2017

1 reference

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Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice

29 September 2017

1 reference

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Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors

29 September 2017

1 reference

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Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo

29 September 2017

1 reference

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Evolution of the Fgf and Fgfr gene families

29 September 2017

1 reference

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Expression of SIBLINGs and their partner MMPs in salivary glands

29 September 2017

1 reference

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Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders

29 September 2017

1 reference

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FGF23 is processed by proprotein convertases but not by PHEX.

29 September 2017

1 reference

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Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

29 September 2017

1 reference

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MEPE has the properties of an osteoblastic phosphatonin and minhibin.

29 September 2017

1 reference

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Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system

29 September 2017

1 reference

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Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent

29 September 2017

1 reference

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FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting

29 September 2017

1 reference

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Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins

29 September 2017

1 reference

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Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein

29 September 2017

1 reference

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Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store

29 September 2017

1 reference

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The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency

29 September 2017

1 reference

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Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production

29 September 2017

1 reference

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Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway

29 September 2017

1 reference

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Ontogeny of Phex/PHEX protein expression in mouse embryo and subcellular localization in osteoblasts

29 September 2017

1 reference

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Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.

29 September 2017

1 reference

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Analysis of recombinant Phex: an endopeptidase in search of a substrate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

29 September 2017

1 reference

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Disruption of klotho gene causes an abnormal energy homeostasis in mice

29 September 2017

1 reference

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Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain

29 September 2017

1 reference

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Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine

29 September 2017

1 reference

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Intrinsic mineralization defect in Hyp mouse osteoblasts

29 September 2017

1 reference

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Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Isolation and partial characterization of a chloride channel gene which is expressed in kidney and is a candidate for Dent's disease (an X-linked hereditary nephrolithiasis).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Role of 1,25-dihydroxyvitamin D3 on intestinal phosphate absorption in rats with a normal vitamin D supply

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Klotho protein promotes adipocyte differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Ouabain and low extracellular potassium inhibit PTH secretion from bovine parathyroid cells by a mechanism that does not involve increases in the cytosolic calcium concentration

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Parathyroid hormone stimulates phosphate efflux through an apparently adenosine 3',5'-monophosphate-independent process in rat parotid cell aggregates

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

An interpretation of acute changes in plasma 45Ca following parathyroid hormone administration to thyroparathyroidectomized rats.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Anti-FGF23 neutralizing antibodies show the physiological role and structural features of FGF23.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Tumor producing fibroblast growth factor 23 localized by two-staged venous sampling

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

FGF23 is elevated in Gambian children with rickets

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Fibroblast growth factor-23 regulates parathyroid hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Pathogenic role of Fgf23 in Hyp mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Skeletal changes in epidermal nevus syndrome: does focal bone disease harbor clues concerning pathogenesis?

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Mineral metabolism, mortality, and morbidity in maintenance hemodialysis.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Differential effects of Npt2a gene ablation and X-linked Hyp mutation on renal expression of Npt2c.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Dentin matrix protein 1 initiates hydroxyapatite formation in vitro

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Serum FGF23 levels in normal and disordered phosphorus homeostasis.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Transcriptional regulation of alpha 2(I) collagen gene expression by fibroblast growth factor-2 in MC3T3-E1 osteoblast-like cells.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586800

Catabolic effects of continuous human PTH (1--38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation

4 September 2018

1 reference

12 December 2020

Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men

1 reference

12 December 2020

Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice

1 reference

12 December 2020

Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice

1 reference

12 December 2020

Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism

1 reference

12 December 2020

Genetic transmission of tumoral calcinosis: autosomal dominant with variable clinical expressivity

1 reference

12 December 2020