Type 1 diabetes as a relapsing-remitting disease? (Q36992950)

17 August 2017

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title

Type 1 diabetes as a relapsing-remitting disease? (English)

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17 August 2017

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Matthias von Herrath

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Kevan Herold

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17 August 2017

Srinath Sanda

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17 August 2017

1 December 2007

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Nature Reviews Immunology

17 August 2017

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7

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988-994

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Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity

17 August 2017

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Citrullination is an inflammation-dependent process

31 March 2020

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A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease

31 March 2020

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Determinant spreading and the dynamics of the autoimmune T-cell repertoire.

31 March 2020

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Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice

31 March 2020

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Posttranslational modifications of self-antigens

31 March 2020

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Interleukin-1 induced impairment in pancreatic islet oxidative metabolism of glucose is potentiated by tumor necrosis factor

31 March 2020

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beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes

31 March 2020

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Interleukin-1 beta depletes insulin messenger ribonucleic acid and increases the heat shock protein hsp70 in mouse pancreatic islets without impairing the glucose metabolism

31 March 2020

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Driver clones and determinant spreading

31 March 2020

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Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition.

31 March 2020

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Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

31 March 2020

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Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy

31 March 2020

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Central and peripheral autoantigen presentation in immune tolerance

31 March 2020

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Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

31 March 2020

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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

31 March 2020

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Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

31 March 2020

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Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial

31 March 2020

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Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

31 March 2020

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Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

31 March 2020

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

31 March 2020

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Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

31 March 2020

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In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

31 March 2020

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CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes

31 March 2020

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Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

31 March 2020

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TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes

31 March 2020

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TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

31 March 2020

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Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse.

31 March 2020

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Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes

31 March 2020

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Viral infections and cell cycle G2/M regulation

31 March 2020

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Redefining the clinical remission period in children with type 1 diabetes.

31 March 2020

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Partial remission phase of diabetes in children younger than age 10 years

31 March 2020

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Partial remission phase and metabolic control in type 1 diabetes mellitus in children and adolescents

31 March 2020

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Millennium award recipient contribution. Identification of children with early onset and high incidence of anti-islet autoantibodies.

31 March 2020

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C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001.

31 March 2020

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Beta-cell function recovery is not the only factor responsible for remission in type I diabetics: evaluation of C-peptide secretion in diabetic children after first metabolic recompensation and at partial remission phase

31 March 2020

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Effects of insulin in relatives of patients with type 1 diabetes mellitus

31 March 2020

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Immunological abnormalities in islets at diagnosis paralleled further deterioration of glycaemic control in patients with recent-onset Type I (insulin-dependent) diabetes mellitus.

31 March 2020

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Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes

31 March 2020

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Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

31 March 2020

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A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

31 March 2020

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Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes

31 March 2020

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Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes

31 March 2020

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Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

31 March 2020

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Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells

31 March 2020

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Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4.

31 March 2020

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Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.

31 March 2020

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Natural history of type 1 diabetes

31 March 2020

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Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2192

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17 August 2017

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PubMed ID

17982429