From therapy to experimental model: a hundred years of endotoxin administration to human subjects (Q36994694)

17 August 2017

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title

From therapy to experimental model: a hundred years of endotoxin administration to human subjects (English)

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human subject research project

17 August 2017

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Marjan Bahador

1

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PubMed ID

17986486

17 August 2017

Alan S Cross

series ordinal

2

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17 August 2017

1 January 2007

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Journal of Endotoxin Research

17 August 2017

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17 August 2017

13

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17 August 2017

5

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17 August 2017

251-279

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Human endotoxemia: a model for mechanistic insight and therapeutic targeting

17 August 2017

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https://api.crossref.org/works/10.1177%2F0968051907085986

Temperature: a critical factor determining localization and natural history of infectious, metabolic, and immunological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

EFFECTS PRODUCED BY THE INTRAVENOUS INJECTION IN MAN OF A TOXIC ANTIGENIC MATERIAL DERIVED FROM EBERTHELLA TYPHOSA: CLINICAL, HEMATOLOGICAL, CHEMICAL AND SEROLOGICAL STUDIES.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

TOLERANCE TO BACTERIAL PYROGENS : I. FACTORS INFLUENCING ITS DEVELOPMENT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

RESISTANCE TO THE ACTION OF THE ENDOTOXINS OF ENTERIC BACILLI IN MAN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

TOLERANCE TO BACTERIAL PYROGENS : II. ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Studies on the generalized Shwartzman reaction: I. General observations concerning the phenomenon

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Role of meningococcal endotoxin in meningococcal purpura

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Detection of circulating tumor necrosis factor after endotoxin administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Granulocyte-macrophage colony-stimulating factor synthesis during experimental endotoxemia in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Production of interleukin-1-receptor antagonist during experimental endotoxaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

The role of endotoxin during typhoid fever and tularemia in man. I. Acquisition of tolerance to endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

MECHANISMS OF ENDOTOXIN TOLERANCE. II. RELATIONSHIP BETWEEN ENDOTOXIN TOLERANCE AND RETICULOENDOTHELIAL SYSTEM PHAGOCYTIC ACTIVITY IN MAN

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

The role of endotoxin during typhoid fever and tularemia in man. IV. The integrity of the endotoxin tolerance mechanisms during infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

MECHANISMS OF ENDOTOXIN TOLERANCE. 3. THE REFRACTORY STATE DURING CONTINUOUS INTRAVENOUS INFUSIONS OF ENDOTOXIN

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

An endotoxin-induced serum factor that causes necrosis of tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Severe vagal response after endotoxin administration in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Brief report: shock and multiple-organ dysfunction after self-administration of Salmonella endotoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Gender influences in vivo human responses to endotoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

The cardiovascular response of normal humans to the administration of endotoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Cardiac troponin I release and cytokine response during experimental human endotoxaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Adrenoceptor hyporeactivity is responsible for Escherichia coli endotoxin-induced acute vascular dysfunction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Effects of ibuprofen and pentoxifylline on the cardiovascular response of normal humans to endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Endotoxin administration to humans primes alveolar macrophages for increased production of inflammatory mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Cerebral blood flow during experimental endotoxemia in volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Diurnal variations in the human host response to endotoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Low-dose endotoxemia and human neuropsychological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Cytokine-associated emotional and cognitive disturbances in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Endotoxin causes release of alpha-melanocyte-stimulating hormone in normal human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Insulin resistance and substrate utilization in human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Circulating leptin levels during acute experimental endotoxemia and antiinflammatory therapy in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Circulating adiponectin levels during human endotoxaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Induction of procalcitonin and proinflammatory cytokines in an anhepatic baboon endotoxin shock model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Model for whole body production of tumour necrosis factor-alpha in experimental endotoxaemia in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Inhibition of the release of soluble tumor necrosis factor receptors in experimental endotoxemia by an anti-tumor necrosis factor-alpha antibody.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Granulocyte colony-stimulating factor receptors on granulocytes are down-regulated after endotoxin administration to healthy humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

The interleukin-6 G(-174)C promoter polymorphism does not determine plasma interleukin-6 concentrations in experimental endotoxemia in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

The fibrinogen -148 C/T polymorphism influences inflammatory response in experimental endotoxemia in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

The tumor necrosis factor alpha -308 G/A polymorphism does not influence inflammation and coagulation response in human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Proinflammatory effects of IL-10 during human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Human endotoxemia induces down-regulation of monocyte CC chemokine receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Hematological indices, inflammatory markers and neutrophil CD64 expression: comparative trends during experimental human endotoxemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Changes in polymorphonuclear leukocyte surface and plasma bactericidal/permeability-increasing protein and plasma lipopolysaccharide binding protein during endotoxemia or sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Interleukin-6 Infusion During Human Endotoxaemia Inhibits In Vitro Release of the Urokinase Receptor from Peripheral Blood Mononuclear Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Effects in humans of intravenously administered endotoxin on soluble cell-adhesion molecule and inflammatory markers: a model of human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Complement activation, endothelin-1 and neuropeptide Y in relation to the cardiovascular response to endotoxin-induced systemic inflammation in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Microvascular permeability during experimental human endotoxemia: an open intervention study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Suppression of the clinical and cytokine response to endotoxin by RWJ-67657, a p38 mitogen-activated protein-kinase inhibitor, in healthy human volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Treatment with an anti-CD14 monoclonal antibody delays and inhibits lipopolysaccharide-induced gene expression in humans in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Antiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Short-term simvastatin treatment has no effect on plasma cytokine response in a human in vivo model of low-grade inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Enalapril does not alter adhesion molecule levels in human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Nicotinamide does not influence cytokines or exhaled NO in human experimental endotoxaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Pretreatment with ibuprofen augments circulating tumor necrosis factor-alpha, interleukin-6, and elastase during acute endotoxinemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Effects of anti-inflammatory agents on serum levels of calcitonin precursors during human experimental endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Pretreatment of normal humans with monophosphoryl lipid A induces tolerance to endotoxin: a prospective, double-blind, randomized, controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

A lipid A analog, E5531, blocks the endotoxin response in human volunteers with experimental endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Extended in Vivo Pharmacodynamic Activity of E5564 in Normal Volunteers with Experimental Endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Procoagulant protein levels are differentially increased during human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: a randomized, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Tissue factor pathway inhibitor does not influence inflammatory pathways during human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Inhibition of plasmin activity by tranexamic acid does not influence inflammatory pathways during human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Epinephrine exerts anticoagulant effects during human endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Effects of anticoagulation on thrombopoietin release during endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Effects of drotrecogin alfa (activated) in human endotoxemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Endotoxemia in human septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

Serum lipopolysaccharide-binding protein in endotoxemic patients with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0968051907085986

21 January 2018

Identifiers

DOI

10.1177/0968051907085986

1 reference

release_ohlhp3xt4rajtlmq6mftsc3qkm

17 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ohlhp3xt4rajtlmq6mftsc3qkm

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

17986486

1 reference

PubMed ID

17986486