Control of erythropoietin gene expression and its use in medicine (Q36999068)

17 August 2017

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title

Control of erythropoietin gene expression and its use in medicine (English)

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17 August 2017

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1

Wolfgang Jelkmann

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17 August 2017

language of work or name

English

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publication date

1 January 2007

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17 August 2017

published in

Methods in Enzymology

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17 August 2017

volume

435

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17 August 2017

page(s)

179-197

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Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

17 August 2017

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7 January 2021

Baboon mesenchymal stem cells can be genetically modified to secrete human erythropoietin in vivo

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Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy

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7 January 2021

Modulation of erythropoietin delivery from engineered muscles in mice

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7 January 2021

Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts

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7 January 2021

Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise

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7 January 2021

Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases

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7 January 2021

New agents that stimulate erythropoiesis

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7 January 2021

The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.

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7 January 2021

Autoimmune anemia in macaques following erythropoietin gene therapy

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7 January 2021

A hypoxia-inducible gene expression system using erythropoietin 3' untranslated region for the gene therapy of rat spinal cord injury

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7 January 2021

Unusual N-glycosylation of a recombinant human erythropoietin expressed in a human lymphoblastoid cell line does not alter its biological properties

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7 January 2021

Modulation of transduced erythropoietin expression by iron

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7 January 2021

Genetic characterization of CHO production host DG44 and derivative recombinant cell lines.

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7 January 2021

Development and characterization of novel erythropoiesis stimulating protein (NESP)

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7 January 2021

Erythropoietin therapy for acute stroke is both safe and beneficial

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7 January 2021

Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin

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7 January 2021

Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression

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7 January 2021

The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1.

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7 January 2021

Erythropoietin gene therapy leads to autoimmune anemia in macaques

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7 January 2021

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

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7 January 2021

Acute postnatal ablation of Hif-2alpha results in anemia

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7 January 2021

Myoblast transfer of human erythropoietin gene in a mouse model of renal failure

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7 January 2021

Humanization of yeast to produce complex terminally sialylated glycoproteins

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7 January 2021

Sodium phosphate enhances plasmid DNA expression in vivo

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7 January 2021

Intracellular functions of N-linked glycans

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7 January 2021

A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA.

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7 January 2021

Long-term production of erythropoietin after electroporation-mediated transfer of plasmid DNA into the muscles of normal and uremic rats.

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7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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7 January 2021

The enigma of the metabolic fate of circulating erythropoietin (Epo) in view of the pharmacokinetics of the recombinant drugs rhEpo and NESP.

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7 January 2021

Erythropoietin after a century of research: younger than ever

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7 January 2021

Beneficial and ominous aspects of the pleiotropic action of erythropoietin

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7 January 2021

Effects of antioxidant vitamins on renal and hepatic erythropoietin production

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7 January 2021

Iron deprivation increases erythropoietin production in vitro, in normal subjects and patients with malignancy

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7 January 2021

Regulation of human erythropoietin gene induction by upstream flanking sequences in transgenic mice

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7 January 2021

Interleukin-1beta inhibits the hypoxic inducibility of the erythropoietin enhancer by suppressing hepatocyte nuclear factor-4alpha

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7 January 2021

Erythropoietin secretion and physiological effect in mouse after intramuscular plasmid DNA electrotransfer

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7 January 2021

Epoetin delta, erythropoietin produced in a human cell line, in the management of anaemia in predialysis chronic kidney disease patients

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7 January 2021

Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappaB.

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7 January 2021

“Genetic Doping” with erythropoietin cDNA in primate muscle is detectable

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7 January 2021

Cloning and expression of the human erythropoietin gene

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7 January 2021

The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis

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7 January 2021

Cobalt chloride administration in athletes: a new perspective in blood doping?

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7 January 2021

Human erythropoietin gene therapy for patients with chronic renal failure

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7 January 2021

Novel strategies for stimulating erythropoiesis and potential new treatments for anaemia

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7 January 2021

Skin-targeted gene transfer using in vivo electroporation.

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7 January 2021

Kidney-targeted naked DNA transfer by retrograde renal vein injection in rats.

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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7 January 2021

Adipose tissue as a novel target for in vivo gene transfer by adeno-associated viral vectors

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7 January 2021

Gene transfer for erythropoiesis enhancement

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7 January 2021

Sustained delivery of erythropoietin in mice by genetically modified skin fibroblasts

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7 January 2021

Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease

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7 January 2021

Failure of human immunoresponse to N-glycolylneuraminic acid epitope contained in recombinant human erythropoietin

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7 January 2021

Oncological implications of hypoxia inducible factor-1alpha (HIF-1alpha) expression

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7 January 2021

Correction of anemia in uremic rats by intramuscular injection of lentivirus carrying an erythropoietin gene

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7 January 2021

Long-term expression of erythropoietin from myoblasts immobilized in biocompatible and neovascularized microcapsules

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7 January 2021

Gene therapy for long-term expression of erythropoietin in rats

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7 January 2021

Improvement of mouse beta-thalassemia by electrotransfer of erythropoietin cDNA.

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7 January 2021

Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene

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7 January 2021

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

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7 January 2021

Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans

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7 January 2021

A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension

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7 January 2021

Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia.

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7 January 2021

Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer.

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7 January 2021

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

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7 January 2021

Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxia

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7 January 2021

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

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7 January 2021

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

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7 January 2021

A cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and Smads

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7 January 2021

A self-immunomodulating myoblast cell line for erythropoietin delivery

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7 January 2021

HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner

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7 January 2021

Progress toward a nonviral gene therapy protocol for the treatment of anemia

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7 January 2021

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

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7 January 2021

Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins

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7 January 2021

Expression systems for the production of recombinant pharmaceuticals

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7 January 2021

Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935010-6

7 January 2021

Epoetin delta is effective for the management of anaemia associated with chronic kidney disease

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935010-6

7 January 2021

Structures and functional roles of the sugar chains of human erythropoietins

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7 January 2021

Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid

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7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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7 January 2021

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

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7 January 2021

Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy

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7 January 2021

Engineering Chinese hamster ovary cells to maximize sialic acid content of recombinant glycoproteins

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7 January 2021

The hypoxic inducible stress response as a target for cancer drug discovery

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7 January 2021

Production of recombinant protein therapeutics in cultivated mammalian cells

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7 January 2021

Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha

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7 January 2021

10.1016/S0076-6879(07)35010-6

Identifiers

DOI

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17 August 2017

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