In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. (Q37001755)

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1 April 2020

title

In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant (English)

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1 April 2020

0 references

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1

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Steven G Reed

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1 April 2020

author name string

Lakshmi Ganapathi

2

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Ilana Bergelson

3

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David J Dowling

4

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Michaela Banks

5

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Ronald C Samuels

6

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Jason D Marshall

8

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Ofer Levy

9

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publication date

12 April 2016

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1 April 2020

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volume

83

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page(s)

99-109

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The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.

1 April 2020

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The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.

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Molecular and cellular response profiles induced by the TLR4 agonist-based adjuvant Glucopyranosyl Lipid A

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Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life.

29 September 2017

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Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro

29 September 2017

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Use of human MonoMac6 cells for development of in vitro assay predictive of adjuvant safety in vivo

29 September 2017

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Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways

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Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses

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Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors

29 September 2017

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29 September 2017

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29 September 2017

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Neonatal innate TLR-mediated responses are distinct from those of adults.

29 September 2017

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29 September 2017

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29 September 2017

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Consent for neonatal research

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells

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MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life.

29 September 2017

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Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells

29 September 2017

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29 September 2017

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TLR4 ligand formulation causes distinct effects on antigen-specific cell-mediated and humoral immune responses

27 June 2018

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27 June 2018

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Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.

27 June 2018

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Age-matched dendritic cell subpopulations reference values in childhood.

4 September 2018

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The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses.

4 September 2018

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Enumeration of human peripheral blood dendritic cells throughout the life

4 September 2018

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4 September 2018

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4 September 2018

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Interferon regulatory factor 7-mediated responses are defective in cord blood plasmacytoid dendritic cells

4 September 2018

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The 23-valent pneumococcal polysaccharide vaccine does not provide additional serotype antibody protection in children who have been primed with two doses of heptavalent pneumococcal conjugate vaccine

4 December 2018

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Blood plasmacytoid dendritic cell responses to CpG oligodeoxynucleotides are impaired in human newborns

4 December 2018

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TLR2 and TLR4 serve distinct roles in the host immune response against Mycobacterium bovis BCG

4 December 2018

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12 December 2020

The ratio between dendritic cells and T cells determines whether prostaglandin E2 has a stimulatory or inhibitory effect

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Endotoxin-stimulated production of IL-6 and IL-8 is increased in short-term cultures of whole blood from healthy term neonates

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Dendritic cells matured by a prostaglandin E2-containing cocktail can produce high levels of IL-12p70 and are more mature and Th1-biased than dendritic cells treated with TNF-α or LPS

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1 April 2020

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1 April 2020

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