Recent insights into the biology of Hodgkin lymphoma: unraveling the mysteries of the Reed-Sternberg cell (Q37004635)

17 August 2017

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title

Recent insights into the biology of Hodgkin lymphoma: unraveling the mysteries of the Reed-Sternberg cell (English)

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17 August 2017

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Michele R Roullet

1

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17 August 2017

Adam Bagg

series ordinal

2

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17 August 2017

publication date

1 November 2007

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Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

17 August 2017

published in

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17 August 2017

volume

7

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17 August 2017

issue

6

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17 August 2017

page(s)

805-820

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Hodgkin's lymphoma: the pathologist's viewpoint

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

The Hodgkin and Reed/Sternberg cell

21 January 2018

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Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development

21 January 2018

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Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Rare occurrence of classical Hodgkin's disease as a T cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Differential expression of activation-induced cytidine deaminase (AID) in nodular lymphocyte-predominant and classical Hodgkin lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Evidence of abortive plasma cell differentiation in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Defective octamer-dependent transcription is responsible for silenced immunoglobulin transcription in Reed-Sternberg cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

The transcription factor PU.1, necessary for B-cell development is expressed in lymphocyte predominance, but not classical Hodgkin's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Failure of B-cell differentiation in mice lacking the transcription factor EBF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Assembling a gene regulatory network for specification of the B cell fate

21 January 2018

1 reference

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Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

The regulation and function of the Id proteins in lymphocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Notch regulation of lymphocyte development and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

The early transcription factor GATA-2 is expressed in classical Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Expression of the human germinal center-associated lymphoma (HGAL) protein identifies a subset of classic Hodgkin lymphoma of germinal center derivation and improved survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

BAFF AND APRIL: a tutorial on B cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Constitutive expression of c-FLIP in Hodgkin and Reed-Sternberg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

STAT3 is constitutively activated in Hodgkin cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Stats: transcriptional control and biological impact

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

AP-1 function and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

JunB expression is a common feature of CD30+ lymphomas and lymphomatoid papulosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Oncogenic kinase signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Autocrine- and paracrine-activated receptor tyrosine kinases in classic Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Expression of the c-met proto-oncogene and its ligand, hepatocyte growth factor, in Hodgkin disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Global correlation of genome and transcriptome changes in classical Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Different incidence and pattern of p15INK4b and p16INK4a promoter region hypermethylation in Hodgkin's and CD30-Positive non-Hodgkin's lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Frequent epigenetic inactivation of the RASSF1A tumor suppressor gene in Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltratein Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Hodgkin's lymphoma associated T-cells exhibit a transcription factor profile consistent with distinct lymphoid compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Galectin-1 mediated suppression of Epstein-Barr virus specific T-cell immunity in classic Hodgkin lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Vascular endothelial growth factor (VEGF) is expressed by neoplastic Hodgkin-Reed-Sternberg cells in Hodgkin's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Epstein-Barr virus-associated Hodgkin's disease: epidemiologic characteristics in international data.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Epstein-Barr virus and oncogenesis: from latent genes to tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Hodgkin's disease in patients with previous infectious mononucleosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Exposure to childhood infections and risk of Epstein-Barr virus--defined Hodgkin's lymphoma in women

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Epstein-Barr virus as a marker of survival after Hodgkin's lymphoma: a population-based study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Measles virus: evidence of an association with Hodgkin's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Absence of measles virus genome and transcripts in Hodgkin-Reed/Sternberg cells of a cohort of Hodgkin lymphoma patients

21 January 2018

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Brief report: reversible lymphomas associated with Epstein-Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis

21 January 2018

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Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Incidence of non-AIDS-defining cancers before and during the highly active antiretroviral therapy era in a cohort of human immunodeficiency virus-infected patients

21 January 2018

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Trends in cancer risk among people with AIDS in the United States 1980-2002.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Why would the incidence of HIV-associated Hodgkin lymphoma increase in the setting of improved immunity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

MAL expression in lymphoid cells: further evidence for MAL as a distinct molecular marker of primary mediastinal large B-cell lymphomas

21 January 2018

1 reference

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Chemotherapy of advanced Hodgkin's disease with MOPP, ABVD, or MOPP alternating with ABVD

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Expression of bcl-2 in classical Hodgkin's lymphoma: an independent predictor of poor outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

HLA class II expression by Hodgkin Reed-Sternberg cells is an independent prognostic factor in classical Hodgkin's lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Current strategies and new approaches in the treatment of Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Novel small-molecule therapy of Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Anti-tumor immunity and autoimmunity: a balancing act of regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Infectious Mononucleosis, Childhood Social Environment, and Risk of Hodgkin Lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

Plasma Cytokine and Soluble Receptor Signature Predicts Outcome of Patients With Classical Hodgkin's Lymphoma: A Study From the Groupe d'Etude des Lymphomes de l'Adulte

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

High serum levels of B-lymphocyte stimulator are associated with clinical?pathological features and outcome in classical Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.6.805

21 January 2018

Identifiers

DOI

10.1586/14737159.7.6.805

1 reference

17 August 2017

1 reference