Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception. (Q37010754)

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3 March 2020

title

Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception (English)

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3 March 2020

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4

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3 March 2020

Alvin J. Beitz

5

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3 March 2020

author name string

Eyup Akgün

1

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3 March 2020

Muhammad I Javed

2

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3 March 2020

Mary M Lunzer

3

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3 March 2020

Philip S Portoghese

6

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language of work or name

English

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publication date

24 June 2013

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Proceedings of the National Academy of Sciences of the United States of America

3 March 2020

published in

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3 March 2020

volume

110

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3 March 2020

issue

28

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3 March 2020

page(s)

11595-11599

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MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys

3 March 2020

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mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo

29 September 2017

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Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

29 September 2017

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Interaction of bivalent ligand KDN21 with heterodimeric delta-kappa opioid receptors in human embryonic kidney 293 cells

29 September 2017

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A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes

29 September 2017

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A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers

29 September 2017

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Some narcotic antagonists in the benzomorphan series

29 September 2017

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Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse

29 September 2017

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The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests.

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Spinal mu-opioid receptor expression and hyperalgesia with dexamethasone in chronic adjuvant-induced arthritis in rats

27 June 2018

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The differential effects of acetaminophen on lipopolysaccharide induced hyperalgesia in various mouse pain models

4 September 2018

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Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB.

4 September 2018

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Upregulation of Group I metabotropic glutamate receptors in neurons and astrocytes in the dorsal horn following spinal cord injury

4 September 2018

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4 September 2018

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Rapid upregulation of mu opioid receptor mRNA in dorsal root ganglia in response to peripheral inflammation depends on neuronal conduction

4 September 2018

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4 September 2018

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4 September 2018

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4 September 2018

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12 December 2020

Intrathecal morphine in mice: a new technique

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12 December 2020

Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms

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Identifiers

DOI

10.1073/PNAS.1305461110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23798416%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

0 references

1 reference

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3 March 2020

PubMed publication ID

23798416

1 reference

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