Cardiac repolarisation and drug regulation: assessing cardiac safety 10 years after the CPMP guidance (Q37012882)

17 August 2017

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title

Cardiac repolarisation and drug regulation: assessing cardiac safety 10 years after the CPMP guidance (English)

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17 August 2017

Rashmi R Shah

1

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17 August 2017

publication date

1 January 2007

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17 August 2017

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17 August 2017

volume

30

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17 August 2017

issue

12

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17 August 2017

page(s)

1093-1110

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QUINIDINE SYNCOPE. PAROXYSMAL VENTRICULAR FIBRILLATION OCCURRING DURING TREATMENT OF CHRONIC ATRIAL ARRHYTHMIAS.

17 August 2017

cites work

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THE SIGNIFICANCE OF ELECTROCARDIOGRAPHIC CHANGES PRODUCED BY THIORIDAZINE.

21 January 2018

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Thioridazine (mellaril)-induced ventricular tachycardia controlled with an artificial pacemaker

21 January 2018

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SUDDEN DEATH DURING TREATMENT WITH PHENOTHIAZINE DERIVATIVES.

21 January 2018

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A Review of the Cardiovascular Effects and Toxicity of Tricyclic Antidepressants

21 January 2018

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Disopyramide induced atypical ventricular tachycardia

21 January 2018

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Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction

21 January 2018

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Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management

21 January 2018

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Primidone in the treatment of the long QT syndrome: QT shortening and ventricular arrhythmia suppression

21 January 2018

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Aminorex to fen/phen: an epidemic foretold

21 January 2018

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Fenfluramine and phentermine and cardiovascular findings: effect of treatment duration on prevalence of valve abnormalities

21 January 2018

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Death Associated With Ventricular Arrhythmia and Thioridazine Hydrochloride

21 January 2018

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12 December 2020

Sudden death associated with short-QT syndrome linked to mutations in HERG.

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12 December 2020

[Bepridil and torsades de pointes. Apropos of 11 cases]

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12 December 2020

Clinical Features in Poisonings by Tricyclic Antidepressants with Special Reference to the ECG

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12 December 2020

Intracardiac conduction defects following overdose of tricyclic antidepressant drugs

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12 December 2020

Comparative efficacy and safety of oral mexiletine and quinidine in benign or potentially lethal ventricular arrhythmias

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12 December 2020

Antiarrhythmic, electrophysiologic and hemodynamic effects of lorcainide

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12 December 2020

Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial

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12 December 2020

Cardiac effects of antidepressant drugs. A comparison of the tricyclic antidepressants and fluvoxamine

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12 December 2020

Disopyramide-Induced Torsade de Pointes

1 reference

12 December 2020

Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability

1 reference

12 December 2020

Electrocardiographic abnormalities induced by thioridazine (Mellaril)

1 reference

12 December 2020

Cardiac toxicity and psychotropic drugs

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12 December 2020

Torsade de pointes ventricular tachycardia associated with lidoflazine therapy

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12 December 2020

Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery

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12 December 2020

The significance of QT interval in drug development

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12 December 2020

[Bepridil and torsades de pointes: are the precautions of use respected?]

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12 December 2020

Electrocardiographic changes induced by phenothiazine drugs

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12 December 2020

Thalidomide, drug safety and early drug regulation in the UK.

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12 December 2020

An electrocardiographic survey of thioridazine treated patients

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12 December 2020

A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents

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12 December 2020

Variability of the QT measurement in healthy men, with implications for selection of an abnormal QT value to predict drug toxicity and proarrhythmia

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12 December 2020

Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery

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12 December 2020

THIORIDAZINE AND ELECTROCARDIOGRAPHIC ABNORMALITIES

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12 December 2020

Ventricular arrhythmias associated with lidoflazine: side-effects observed in a randomized trial

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12 December 2020

Study of cardiac repolarization in healthy volunteers performed with mizolastine, a new H1-receptor antagonist

1 reference

12 December 2020

Dispersion-based reentry: mechanism of initiation of ventricular tachycardia in isolated rabbit hearts

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12 December 2020

Haemodynamic and metabolic effects of the antiarrhythmic drug melperone during acute left ventricular failure in dogs

1 reference

12 December 2020

Ventricular tachycardia with 2 variable opposing foci

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12 December 2020

The effect of neuroleptics on electrocardiograms

1 reference

12 December 2020

Pulmonary hypertension and fenfluramine

1 reference

12 December 2020

Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event

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12 December 2020

Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry: results of an international survey

1 reference

12 December 2020

Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity

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12 December 2020

Valvular heart disease and the use of dopamine agonists for Parkinson's disease

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12 December 2020

Heart failure induced by non-cardiac drugs

1 reference

12 December 2020

Potassium channel openers act through an activation of ATP-sensitive K+ channels in guinea-pig cardiac myocytes

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12 December 2020

Prenylamine and syncopal crisis with prolonged Q-T

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12 December 2020

Electrophysiologic and arrhythmogenic effects of the potassium channel agonist BRL 38227 in anesthetized dogs.

1 reference

12 December 2020

Antiarrhythmic properties of a neuroleptic butyrophenone, melperone, in acute myocardial infarction. A double-blind trial

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12 December 2020

Dopamine agonists and the risk of cardiac-valve regurgitation

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12 December 2020

Nicorandil suppresses a hump on the monophasic action potential and torsade de pointes in a patient with idiopathic long QT syndrome

1 reference

12 December 2020

Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

1 reference

12 December 2020

Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel

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12 December 2020

Stereoselective cardiotoxic effects of terodiline

1 reference

12 December 2020

A comparison of bepridil with amiodarone in the treatment of established atrial fibrillation

1 reference

12 December 2020

The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology

1 reference

12 December 2020

Comparison of lidoflazine and quindine in prophylactic treatment of arrhythmias

1 reference

12 December 2020

Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome

1 reference

12 December 2020

Current status of class III antiarrhythmic drug therapy

1 reference

12 December 2020

Comparative electrophysiology of lorcainide and norlorcainide in the dog

1 reference

12 December 2020

Proarrhythmic effects of antiarrhythmic drugs

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12 December 2020

Idiopathic short QT interval: a new clinical syndrome?

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12 December 2020

Exploring the hidden danger of noncardiac drugs.

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12 December 2020

Congenital deaf-mutism, prolonged QT interval, syncopal attacks and sudden death

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12 December 2020

Mutation in the KCNQ1 gene leading to the short QT-interval syndrome

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12 December 2020

The arrhythmogenicity of antiarrhythmic agents

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12 December 2020

Paroxysmal ventricular tachycardia associated with Adams-Stokes syndrome during treatment with clinium

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12 December 2020

Torsade de pointes induced by N-Acetylprocainamide

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12 December 2020

Clinical experience of encainide (MJ 9067): A new anti-arrhythmic drug

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12 December 2020

Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death

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12 December 2020

VENTRICULAR TACHYCARDIA ASSOCIATED WITH ADMINISTRATION OF THIORIDAZINE HYDROCHLORIDE (MELLARIL): REPORT OF A CASE WITH A FAVOURABLE OUTCOME

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12 December 2020

A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization

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12 December 2020

A viewpoint on drugs that prolong the QTc interval

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12 December 2020

[Electrophysiologic effects of lorcainide (R 15889) in man]

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12 December 2020

The shortage of short QT intervals

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12 December 2020

The short QT syndrome as a paradigm to understand the role of potassium channels in ventricular fibrillation

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12 December 2020

Metabolites of cardiac antiarrhythmic drugs: their clinical role

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12 December 2020

Dose and duration of fenfluramine-phentermine therapy impacts the risk of significant valvular heart disease

1 reference

12 December 2020

A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene

1 reference

12 December 2020

The effect of tricyclic antidepressant drugs on the heart

1 reference

12 December 2020

Electrocardiographic changes, disturbances of cardiac rhythm, and sudden deaths during treatment with phenothiazine drugs

1 reference

12 December 2020

Is idiopathic ventricular fibrillation a short QT syndrome? Comparison of QT intervals of patients with idiopathic ventricular fibrillation and healthy controls

1 reference

12 December 2020

Arrhythmogenic effects of toxic concentrations of the antiarrhythmic drug lorcainide on the isolated canine ventricle

1 reference

12 December 2020

THE MECHANISM OF DEATH FROM QUINIDINE AND A METHOD OF RESUSCITATION; AN EXPERIMENTAL STUDY

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12 December 2020

Understanding consequences of concurrent therapies

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12 December 2020

Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death

1 reference

12 December 2020

Pericardial, retroperitoneal, and pleural fibrosis induced by pergolide

1 reference

12 December 2020

Prevalence and prognostic significance of short QT interval in a middle-aged Finnish population

1 reference

12 December 2020

Recurrent atypical ventricular tachycardia "torsade de pointes" following lidoflazine administration

1 reference

12 December 2020

Lidoflazine is a high affinity blocker of the HERG K(+)channel

1 reference

12 December 2020

Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol.

1 reference

12 December 2020

EKG T-wave distortions among thioridazine-treated psychiatric inpatients (some correlates of the incidence and severity)

1 reference

12 December 2020

Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts?

1 reference

12 December 2020

QT interval variables from 24 hour electrocardiography and the two year risk of sudden death

1 reference

12 December 2020

THIORIDAZINE HYDROCHLORIDE (MELLARIL): ITS EFFECT ON THE ELECTROCARDIOGRAM AND A REPORT OF TWO FATALITIES WITH ELECTROCARDIOGRAPHIC ABNORMALITIES

1 reference

12 December 2020

Effects of a K(+) channel opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of the long-QT syndrome

1 reference

12 December 2020

Trial of pioglitazone for the secondary prevention of cardiovascular events in patients with diabetes mellitus type 2: insufficient evidence

1 reference

12 December 2020

The role of scientific evidence of risks and benefits in determining risk management policies for medications.

1 reference

12 December 2020

Intramyocardial lesions in patients dying suddenly and unexpectedly.

1 reference

12 December 2020

Syncopes and electrocardiographic changes caused by prenylamine

1 reference

12 December 2020

Cardiovascular safety of 5HT1B/1D agonists--is there a cause for concern?

1 reference

12 December 2020

Significance of QT prolongation in the electrocardiogram: based on the study of 168 cases

1 reference

12 December 2020

Malignant ventricular tachyarrhythmias associated with the use of encainide

1 reference

12 December 2020

Effects of thioridazine on transmembrane potential and contractile characteristics of guinea pig hearts

1 reference

12 December 2020

A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN

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12 December 2020

Ventricular arrhythmias caused by prenylamine.

1 reference

12 December 2020

Efficacy and safety of the cyclooxygenase 2 inhibitors parecoxib and valdecoxib in patients undergoing coronary artery bypass surgery.

1 reference

12 December 2020

Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies

1 reference

12 December 2020

RARE CARDIAC ARRYTHMIAS OF THE PEDIATRIC AGE. II. SYNCOPAL ATTACKS DUE TO PAROXYSMAL VENTRICULAR FIBRILLATION. (PRESENTATION OF 1ST CASE IN ITALIAN PEDIATRIC LITERATURE)

1 reference

12 December 2020

ELECTROCARDIOGRAPHIC CHANGES ASSOCIATED WITH THE USE OF THIORIDAZINE

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12 December 2020

Distribution and prognostic significance of QT intervals in the lowest half centile in 12,012 apparently healthy persons

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12 December 2020

Beneficial and detrimental effects of lidoflazine in microvascular angina

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12 December 2020

THE EFFECT OF PHENOTHIAZINES ON THE ELECTROCARDIOGRAM

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12 December 2020

Electrocardiographic changes produced by thioridazine and chlorpromazine

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12 December 2020

Comparison of proarrhythmogenic effects of two potassium channel openers, levcromakalim (BRL 38227) and nicorandil (RP 46417): a high-resolution mapping study on rabbit heart

1 reference

12 December 2020

Cardiac changes related to phenothiazine therapy, with special reference to thioridazine

1 reference

12 December 2020

International Conference on Harmonisation; guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs; availability. Notice.

1 reference

12 December 2020

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

1 reference

12 December 2020

Safety of drug therapies used for weight loss and treatment of obesity

1 reference

12 December 2020

Amplification of spatial dispersion of repolarization underlies sudden cardiac death associated with catecholaminergic polymorphic VT, long QT, short QT and Brugada syndromes

1 reference

12 December 2020

Drug-induced Pulmonary Hypertension?

1 reference

12 December 2020

Proarrhythmia, arrhythmogenesis or aggravation of arrhythmia--a status report, 1987

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12 December 2020

Long QT syndrome during high-dose cisapride

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12 December 2020

1 reference

12 December 2020

Torsades de pointes as a manifestation of mexiletine toxicity

1 reference

12 December 2020

Long QT, syncope caused by atypical ventricular fibrillation and chronic ingestion of prenylamine (review of the literature and report of a case

1 reference

12 December 2020

Is QT interval prolongation harmful? A regulatory perspective

1 reference

12 December 2020

Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus

1 reference

12 December 2020

Pulmonary hypertension and dexfenfluramine

1 reference

12 December 2020

GI262570, a peroxisome proliferator-activated receptor {gamma} agonist, changes electrolytes and water reabsorption from the distal nephron in rats

1 reference

12 December 2020

Nine cases of torsade de pointes with bepridil administration

1 reference

12 December 2020

Short QT syndrome: clinical findings and diagnostic-therapeutic implications

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12 December 2020

Quinidine as a cause of sudden death

1 reference

12 December 2020

QTc Interval Prolongation: Is It Beneficial or Harmful? Symposium proceedings. Philadelphia, Pennsylvania, October 29, 1992

1 reference

12 December 2020

10.2165/00002018-200730120-00003

Identifiers

DOI

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Dimensions Publication ID

17 August 2017

1039573153

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