Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells (Q37016158)

17 August 2017

Synthesis, retention, and biological activity of methotrexate polyglutamates in cultured human breast cancer cells (English)

1 reference

https://api.crossref.org/works/10.1172/JCI110624

17 August 2017

Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells (English)

1 reference

22 August 2023

0 references

1 reference

1 reference

J. Jolivet

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6178756

22 August 2023

R. L. Schilsky

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6178756

22 August 2023

B. D. Bailey

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6178756

22 August 2023

J. C. Drake

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6178756

22 August 2023

B. A. Chabner

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6178756

22 August 2023

language of work or name

English

0 references

publication date

1 August 1982

1 reference

full work available at URL

17 August 2017

https://europepmc.org/articles/PMC371243

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6178756

https://europepmc.org/articles/PMC371243?pdf=render

22 August 2023

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6178756

http://www.jci.org/articles/view/110624/files/pdf

22 August 2023

1 reference

https://api.crossref.org/works/10.1172/JCI110624

Journal of Clinical Investigation

22 August 2023

published in

1 reference

17 August 2017

70

1 reference

17 August 2017

2

1 reference

17 August 2017

351-360

1 reference

describes a project that uses

17 August 2017

ZR-75-B

0 references

cites work

Protein measurement with the Folin phenol reagent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

Transport, binding, and polyglutamation of methotrexate in freshly isolated rat hepatocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

Methotrexate polyglutamate synthesis by cultured human breast cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

Breast tumor cell lines from pleural effusions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

A human cell line from a pleural effusion derived from a breast carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

Tissue-specific synthesis of methotrexate polyglutamates in the rat

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

Competitive protein binding assay for methotrexate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

Natural resistance to methotrexate in human acute nonlymphocytic leukemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

The application of rapid kinetic techniques to the transport of thymidine and 3-O-methylglucose into mammalian cells in suspension culture

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

Effects of methotrexate esters and other lipophilic antifolates on methotrexate-resistant human leukemic lymphoblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

Synthesis and biological evaluation of poly-gamma-glutamyl derivatives of methotrexate.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

Polygammaglutamyl metabolites of methotrexate.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

Establishment and characterization of three new continuous cell lines derived from human breast carcinomas

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

Accumulation of methotrexate diglutamate in human liver during methotrexate therapy

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371243

The mechanism of action of methotrexate. III. Requirement of free intracellular methotrexate for maximal suppression of (14C)formate incorporation into nucleic acids and protein

27 June 2018

1 reference

12 December 2020

Synthesis of methotrexate polyglutamates in cultured human cells

1 reference

12 December 2020

Prolonged inhibition of DNA synthesis associated with the accumulation of methotrexate polyglutamates by cultured human cells

1 reference

12 December 2020

Polyglutamate derivatives of folic acid coenzymes and methotrexate

1 reference

12 December 2020

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate

1 reference

12 December 2020

Extracellular recovery of methotrexate-polyglutamates following efflux from L1210 leukemia cells

1 reference

12 December 2020

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

1 reference

12 December 2020

Synthesis of methotrexate polyglutamates by bone marrow cells from patients with leukemia and lymphoma

1 reference

12 December 2020

Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro

1 reference

12 December 2020

High-pressure liquid chromatography analysis of methotrexate polyglutamates in cultured human breast cancer cells

1 reference

12 December 2020

Characteristics of membrane transport of methotrexate by cultured human breast cancer cells

1 reference

12 December 2020

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo

1 reference

12 December 2020

Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro

1 reference

12 December 2020

Enzymatic reduction of dihydrofolic acid

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI110624

1 reference

17 August 2017

1 reference

17 August 2017

1 reference