Akt in the pathogenesis of COPD. (Q37018918)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

review article

1 reference

title

Akt in the pathogenesis of COPD (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

chronic obstructive pulmonary disease

28 December 2019

main subject

pathogenesis

0 references

1 reference

28 September 2019

1 reference

28 September 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

author name string

Ross Vlahos

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Michelle Hansen

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Ken Liu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Gary P Anderson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

language of work or name

English

0 references

publication date

1 January 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

International Journal of Chronic Obstructive Pulmonary Disease

28 December 2019

published in

2 references

28 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

volume

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

page(s)

31-38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema

28 December 2019

cites work

1 reference

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The nature of small-airway obstruction in chronic obstructive pulmonary disease

29 September 2017

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Proinflammatory cytokines and skeletal muscle

29 September 2017

1 reference

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Low lung function and incident lung cancer in the United States: data From the First National Health and Nutrition Examination Survey follow-up

29 September 2017

1 reference

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Signalling pathways that mediate skeletal muscle hypertrophy and atrophy

29 September 2017

1 reference

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Acquired somatic mutations in the molecular pathogenesis of COPD.

29 September 2017

1 reference

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Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

29 September 2017

1 reference

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Smoking molecular damage in bronchial epithelium

29 September 2017

1 reference

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

29 September 2017

1 reference

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Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.

29 September 2017

1 reference

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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Oxidants/antioxidants and COPD.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

The potential of various lipopolysaccharides to release IL-8 and G-CSF.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Cellular survival: a play in three Akts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

The protein kinase ABC's of signal transduction as targets for drug development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Regulation of cell death protease caspase-9 by phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Molecular damage in the bronchial epithelium of current and former smokers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Alveolar macrophage replication. One mechanism for the expansion of the mononuclear phagocyte population in the chronically inflamed lung

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Smoke extract stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activity

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Reduced spontaneous apoptosis in peripheral blood neutrophils during exacerbation of COPD.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Nicotine-induced phosphorylation of Akt through epidermal growth factor receptor and Src in PC12h cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706607

Chronic obstructive pulmonary disease

4 September 2018

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

The incidence of airflow obstruction in bronchial carcinoma, its relation to breathlessness, and response to bronchodilator therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

Alveolar inflammation and its relation to emphysema in smokers

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

Bacterial endotoxin is an active component of cigarette smoke

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

The potential of various lipopolysaccharides to release monocyte chemotactic activity from lung epithelial cells and fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

Cancer research. Inflammation and cancer: the link grows stronger

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

TNF-alpha stimulation of MCP-1 expression is mediated by the Akt/PKB signal transduction pathway in vascular endothelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

PDGF-induced Akt phosphorylation does not activate NF-kappa B in human vascular smooth muscle cells and fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

The expression of chemokine genes correlates with nuclear factor-kappaB activation in human pancreatic cancer cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

ETS1, NFkappaB and AP1 synergistically transactivate the human GM-CSF promoter

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

Increased p21CIP1/WAF1and B Cell Lymphoma Leukemia-xLExpression and Reduced Apoptosis in Alveolar Macrophages from Smokers

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

Effect of smoking cessation on airway inflammation in chronic bronchitis

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FCOPD.2006.1.1.31

Inhibition of vascular endothelial growth factor receptors causes emphysema in rats

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18046900

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High frequency of K-ras codon 12 mutations in bronchoalveolar lavage fluid of patients at high risk for second primary lung cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18046900

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2147/COPD.2006.1.1.31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18046900%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

PubMed publication ID

18046900

1 reference