Host-pathogen interactions in sepsis (Q37026360)

17 August 2017

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title

Host-pathogen interactions in sepsis (English)

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17 August 2017

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1

Tom van der Poll

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17 August 2017

Steven M Opal

2

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17 August 2017

11 December 2007

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Lancet Infectious Diseases

17 August 2017

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17 August 2017

8

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17 August 2017

1

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17 August 2017

32-43

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Treating patients with severe sepsis

17 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

The epidemiology of sepsis in the United States from 1979 through 2000

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated).

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Insights into host responses against pathogens from transcriptional profiling.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Frontal and stealth attack strategies in microbial pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

PapG-dependent adherence breaks mucosal inertia and triggers the innate host response.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Immunomodulation and sepsis: impact of the pathogen

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Autoinduction and signal transduction in the regulation of staphylococcal virulence

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Superantigens and streptococcal toxic shock syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Type III secretion machines: bacterial devices for protein delivery into host cells

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Endotoxin as a drug target

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Innate immune sensing and its roots: the story of endotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Pathogenicity islands and the evolution of microbes

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Salmonella pathogenicity islands: big virulence in small packages.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Pathogenicity islands in bacterial pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Phylogenetic analysis and prevalence of urosepsis strains of Escherichia coli bearing pathogenicity island-like domains

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Structural basis for broad DNA-specificity in integron recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Methicillin-ResistantS. aureusInfections among Patients in the Emergency Department

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Tracking the microbes in sepsis: advancements in treatment bring challenges for microbial epidemiology.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Small talk. Cell-to-cell communication in bacteria.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Acyl-homoserine lactone quorum sensing in gram-negative bacteria: a signaling mechanism involved in associations with higher organisms

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Comparative antibody-mediated phagocytosis of Staphylococcus epidermidis cells grown in a biofilm or in the planktonic state

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Inter-kingdom signaling: deciphering the language of acyl homoserine lactones

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Quorum Sensing in Bacteria

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in Staphylococcus aureus.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

The impact of stress and nutrition on bacterial-host interactions at the intestinal epithelial surface

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Recognition of host immune activation by Pseudomonas aeruginosa

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Human and microbe: united we stand

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Pathogen recognition and innate immunity

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

DAMPs, PAMPs and alarmins: all we need to know about danger

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Negative regulation of toll-like receptor-mediated immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

The inflammasome: first line of the immune response to cell stress

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

The inflammasome--a linebacker of innate defense.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemia

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Treatment effects of high-dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Two-way interactions between inflammation and coagulation

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

The interactions between inflammation and coagulation

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Disseminated intravascular coagulation

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Efficacy and safety of recombinant human activated protein C for severe sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Plasminogen activator inhibitor type 1 gene polymorphism and sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Clinical aspects: from systemic inflammation to 'immunoparalysis'.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

The pathophysiology and treatment of sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Apoptosis and caspases regulate death and inflammation in sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Normal responses to injury prevent systemic inflammation and can be immunosuppressive

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Leukocyte apoptosis and its significance in sepsis and shock

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Immunosuppressive effects of apoptotic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Gone but not forgotten

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Depletion of dendritic cells, but not macrophages, in patients with sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Monocyte deactivation in septic patients: restoration by IFN-gamma treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

HMG-1 as a late mediator of endotoxin lethality in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Reversing established sepsis with antagonists of endogenous high-mobility group box 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock*

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Role of HMGB1 in apoptosis-mediated sepsis lethality

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Pivotal advance: analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin).

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

RAGE (receptor for advanced glycation end products): a central player in the inflammatory response

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

The inflammatory reflex

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Physiology and immunology of the cholinergic antiinflammatory pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

MIF as a glucocorticoid-induced modulator of cytokine production

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Protection from septic shock by neutralization of macrophage migration inhibitory factor

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

MIF regulates innate immune responses through modulation of Toll-like receptor 4

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Human macrophage migration inhibitory factor: a proven immunomodulatory cytokine?

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Role of C5a in inflammatory responses

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Protective effects of C5a blockade in sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Increased C5a receptor expression in sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Neutrophil apoptosis pathways and their modifications in inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Intensive insulin therapy in critically ill patients

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Intensive insulin therapy in the medical ICU.

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

Statins: panacea for sepsis?

1 reference

https://api.crossref.org/works/10.1016%2FS1473-3099%2807%2970265-7

7 January 2021

10.1016/S1473-3099(07)70265-7

Identifiers

DOI

1 reference

17 August 2017

1 reference

PubMed ID

18063412