Stem cell-based cell therapy for Huntington disease: a review (Q37028233)

17 August 2017

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title

Stem cell-based cell therapy for Huntington disease: a review (English)

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17 August 2017

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1

Manho Kim

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17 August 2017

3

Kon Chu

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17 August 2017

2

Soon-Tae Lee

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17 August 2017

Seung U Kim

4

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17 August 2017

5 December 2007

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17 August 2017

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17 August 2017

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17 August 2017

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17 August 2017

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Cell replacement therapies for central nervous system disorders.

17 August 2017

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https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Mammalian neural stem cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Human neural stem cells genetically modified for brain repair in neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Stem cells for the treatment of neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Gene therapy: can neural stem cells deliver?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Normal huntingtin function: an alternative approach to Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Aging and neurodegeneration. Molecular mechanisms of neuronal loss in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Differential loss of striatal projection neurons in Huntington disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

A worldwide study of the Huntington's disease mutation. The sensitivity and specificity of measuring CAG repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Glutamine repeats and neurodegenerative diseases: molecular aspects

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Mutant huntingtin enhances excitotoxic cell death.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Cell therapy in Huntington's disease.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

The quinolinic acid model of Huntington's disease: locomotor abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Graft-induced behavioral recovery in an animal model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Excitotoxic injury of the neostriatum: a model for Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Systemic 3-nitropropionic acid: behavioral deficits and striatal damage in adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Selective sparing of a class of striatal neurons in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Reversal of long-term locomotor abnormalities in the kainic acid model of huntington's disease by day 18 fetal striatal implants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Anatomy and connectivity of intrastriatal striatal transplants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Noninvasive method of immortalized neural stem-like cell transplantation in an experimental model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Striatal transplantation in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Anterior cingulate cortical transplantation in transgenic Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Safety and tolerability assessment of intrastriatal neural allografts in five patients with Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Striatal neural grafting improves cortical metabolism in Huntington's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Bilateral human fetal striatal transplantation in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Safety of intrastriatal neurotransplantation for Huntington's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Neuropsychological functioning following fetal striatal transplantation in Huntington's chorea: three case presentations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Stereotactic technique and pathophysiological mechanisms of neurotransplantation in Huntington's chorea

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington's disease human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Grafts of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice: trophic and tropic effects in a rodent model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Human neural stem cell transplants improve motor function in a rat model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Preservation of striatal tissue and behavioral function after neural stem cell transplantation in a rat model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Distribution and in situ proliferation patterns of intravenously injected immortalized human neural stem-like cells in rats with focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Autologous adult bone marrow stem cell transplantation in an animal model of huntington's disease: behavioral and morphological outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

PEX-producing human neural stem cells inhibit tumor growth in a mouse glioma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Human neural stem cells target and deliver therapeutic gene to experimental leptomeningeal medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

Abnormalities of neurogenesis in the R6/2 mouse model of Huntington's disease are attributable to the in vivo microenvironment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1789.2007.00858.X

10.1111/J.1440-1789.2007.00858.X

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference

PubMed ID

18069970