Ligand promiscuity through the eyes of the aminoglycoside N3 acetyltransferase IIa. (Q37034579)

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29 February 2020

title

Ligand promiscuity through the eyes of the aminoglycoside N3 acetyltransferase IIa (English)

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2

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29 February 2020

author name string

Adrianne L Norris

series ordinal

1

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publication date

1 July 2013

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29 February 2020

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volume

22

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issue

7

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29 February 2020

page(s)

916-928

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Comparing aminoglycoside binding sites in bacterial ribosomal RNA and aminoglycoside modifying enzymes

29 February 2020

cites work

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Effect of protein dynamics and solvent in ligand recognition by promiscuous aminoglycoside-modifying enzymes.

29 September 2017

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Protein dynamics and allostery: an NMR view

29 September 2017

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Global dynamics of proteins: bridging between structure and function

29 September 2017

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Detection of specific solvent rearrangement regions of an enzyme: NMR and ITC studies with aminoglycoside phosphotransferase(3')-IIIa

29 September 2017

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On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation

29 September 2017

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Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates

29 September 2017

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29 September 2017

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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

29 September 2017

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Tuberculosis treatment for the beginning of the next century

29 September 2017

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29 September 2017

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Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.

29 September 2017

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Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: overexpression, purification, and substrate specificity

29 September 2017

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Construction of a probe for the aminoglycoside 3-V-acetyltransferase gene and detection of the gene among endemic clinical isolates

29 September 2017

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Interaction of antibiotics with functional sites in 16S ribosomal RNA

29 September 2017

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Nucleotide sequence of the aacC2 gene, a gentamicin resistance determinant involved in a hospital epidemic of multiply resistant members of the family Enterobacteriaceae

29 September 2017

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Calorimetrically determined dynamics of complex unfolding transitions in proteins

29 September 2017

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Synthesis of a tight-binding, multisubstrate analog inhibitor of gentamicin acetyltransferase I

29 September 2017

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Evaluation of linked protonation effects in protein binding reactions using isothermal titration calorimetry

29 September 2017

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Calorimetric determination of the heat of oxygenation of human hemoglobin as a function of pH and the extent of reaction

27 June 2018

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Genes for gentamicin-(3)-N-acetyl-transferases III and IV. II. Nucleotide sequences of three AAC(3)-III genes and evolutionary aspects.

27 June 2018

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Characterization of two aminoglycoside-(3)-N-acetyltransferase genes and assay as epidemiological probes

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719086

Thermodynamic characterization of a thermostable antibiotic resistance enzyme, the aminoglycoside nucleotidyltransferase (4').

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719086

Coenzyme A binding to the aminoglycoside acetyltransferase (3)-IIIb increases conformational sampling of antibiotic binding site.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719086

Antibiotic selection by the promiscuous aminoglycoside acetyltransferase-(3)-IIIb is thermodynamically achieved through the control of solvent rearrangement

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719086

Interactions of coenzyme A with the aminoglycoside acetyltransferase (3)-IIIb and thermodynamics of a ternary system.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719086

Thermodynamics and kinetics of association of antibiotics with the aminoglycoside acetyltransferase (3)-IIIb, a resistance-causing enzyme

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719086

Predictors of mortality and impact of aminoglycosides on outcome in listeriosis in a retrospective cohort study.

4 September 2018

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NMR detected hydrogen-deuterium exchange reveals differential dynamics of antibiotic- and nucleotide-bound aminoglycoside phosphotransferase 3'-IIIa.

4 September 2018

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Deciphering interactions of the aminoglycoside phosphotransferase(3')-IIIa with its ligands.

4 September 2018

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Molecular determinants of affinity for aminoglycoside binding to the aminoglycoside nucleotidyltransferase(2'')-Ia.

4 September 2018

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Thermodynamics of aminoglycoside binding to aminoglycoside-3'-phosphotransferase IIIa studied by isothermal titration calorimetry

4 September 2018

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Cloning, overexpression, and purification of aminoglycoside antibiotic 3-acetyltransferase-IIIb: conformational studies with bound substrates.

4 September 2018

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Thermodynamics of aminoglycoside and acyl-coenzyme A binding to the Salmonella enterica AAC(6')-Iy aminoglycoside N-acetyltransferase

4 September 2018

1 reference

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Mechanism of Streptomycin Action on Bacteria: A Unitary Hypothesis

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FPRO.2273

Regio- and Chemoselective 6′-N-Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6′-N-Acetyltransferases

21 January 2018

1 reference

12 December 2020

Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases

1 reference

12 December 2020

Dissection of aminoglycoside-enzyme interactions: a calorimetric and NMR study of neomycin B binding to the aminoglycoside phosphotransferase(3')-IIIa

1 reference

12 December 2020

ATP binding enables broad antibiotic selectivity of aminoglycoside phosphotransferase(3')-IIIa: an elastic network analysis

1 reference

12 December 2020

Identifiers

DOI

10.1002/PRO.2273

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29 February 2020

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29 February 2020

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